Uses of undefined

Imipenem is prescribed to treat a wide range of serious bacterial infections, including:

• Lower respiratory tract infections: Effective in treating bacterial pneumonia and other severe lung infections.
• Intra-abdominal infections: Used to manage infections in the abdomen, often caused by Gram-negative bacteria.
• Urinary tract infections (UTIs): Treats complicated UTIs, particularly in patients with multi-drug resistant pathogens.
• Skin and soft tissue infections: Addresses infections resulting from resistant bacteria, commonly seen in hospital settings.
• Gynaecological infections: Effective in treating infections of the female reproductive organs.

undefined Drug administaration and Dosage available

Imipenem is available for intravenous administration, often combined with Cilastatin, a compound that prevents the antibiotic from being broken down in the kidneys, allowing higher concentrations in the bloodstream. The dosage varies based on infection severity and patient factors, generally ranging from 250 mg to 1 g every 6-8 hours. A healthcare professional should determine the precise dose and frequency.

Warnings, Precautions and Side Effects of undefined

Warnings

• Seizure Risk: Imipenem may raise the likelihood of seizures, particularly in individuals with a history of central nervous system (CNS) disorders or those receiving high doses.
• Hypersensitivity Reactions: Like other beta-lactam antibiotics, Imipenem can cause allergic reactions, including anaphylaxis, particularly in individuals with penicillin allergies.
• Renal Impairment: Adjustments in dosage may be required for patients with kidney dysfunction, as the drug is primarily eliminated by the kidneys.

Precautions

• Avoid using Imipenem in patients with known allergies to carbapenems or beta-lactams.
• Extra caution is recommended for elderly patients, as they may be more prone to side effects, including CNS-related reactions.
• Monitor kidney function regularly, as Imipenem is excreted by the kidneys and may accumulate in cases of impaired renal function.
• Ensure proper hydration during treatment to minimise the risk of renal complications.

Side Effects

Common side effects of Imipenem include:

• Nausea and vomiting
• Diarrhea
• Skin rash
• Injection site reactions
• Dizziness

More severe side effects, though rare, include seizures, confusion, severe allergic reactions, and Clostridioides difficile-associated diarrhoea.

Word Of Advice

It’s important to finish the entire prescribed course of Imipenem to prevent resistance and ensure full recovery. If you experience unusual symptoms such as a severe headache, confusion, or a rash, seek medical attention, as these could signal an adverse reaction. Stay hydrated to help support kidney function and minimise the risk of renal side effects. Patients using Imipenem, especially those with kidney issues or a history of seizures, should have their kidney function and central nervous system monitored regularly.

Frequently Asked Question

• Why is Imipenem combined with Cilastatin?
• Cilastatin inhibits the renal enzyme that breaks down Imipenem, helping to maintain effective levels of the antibiotic in the bloodstream and enhancing its efficacy.

• Can Imipenem treat MRSA infections?
• No, Imipenem is generally ineffective against methicillin-resistant Staphylococcus aureus (MRSA). Other antibiotics, such as vancomycin or linezolid, are typically used for MRSA.

• Is Imipenem safe during pregnancy?
• Imipenem should be used in pregnancy only if clearly needed and prescribed by a doctor, as data on its safety during pregnancy are limited.

• How long does Imipenem take to work?
• Imipenem starts acting quickly, often within hours, but the duration of treatment depends on the type and severity of the infection.

• Can Imipenem cause kidney damage?
• Imipenem may impact kidney function, especially in patients with pre-existing renal issues. Regular monitoring and hydration are recommended to reduce this risk.