Ketoanalogue + essential amino acids are approved as nutritional supplements to improve the nutritional status of patients with chronic kidney disease.

Ketoanalogue + essential amino acids has been developed to prevent and treat kidney damage in patients with chronic kidney disease It corrects faulty protein metabolism due to low protein intake (less than 40g/day). It delays the disease progression and the onset of dialysis treatment by preserving the nutritional status.

Ketoanalogue + essential amino acids are available in the form of powder, granules and tablets. The dose and frequency vary according to body weight. 

Ketoanalogue + essential amino acids are not associated with any serious side effects. However, hypercalcemia is the most common side effect. 

During the Ketoanalogue + essential amino acids treatment, your doctor may periodically monitor your serum calcium, serum phosphate, and other kidney parameters to prevent serious complications. Report to your doctor if you have been diagnosed with hereditary phenylketonuria. 

There is insufficient information about the impact of ketoanalogue + essential amino acids on pregnant and breastfeeding women. Exercise caution before using ketoanalogue + essential amino acids during pregnancy and breastfeeding.

Your healthcare provider will regularly monitor your serum calcium levels to check for hypercalcemia and suggest reducing the intake of calcium and vitamin D sources.

Eat a calorie-rich diet. Take ketoanalogue + essential amino acids only on your healthcare provider’s recommendation. Inform your doctor if you have any other kidney disease and about all the underlying medical conditions. Do not stop the medicine until your doctor advises. Do not double-dose the medicine to make up for a forgotten dose. Notify your doctor if you experience any serious side effects. Your medical professional will inform you if you need any dose adjustments. Contact your doctor for more information. 

1. Rivpra formulation PVT LTD, add manufactrer [Revised on Jan 2021] [Accessed on Nov 2023], https://www.centaurpharma.com/downloads/2021/nephrology/NEFROGARD.pdf
2. Alexander Zemchenkov, Irina N.Konakova; Efficacy of the Essential Amino Acids and Keto-Analogues on the CKD progression rate in real practice in Russia - city nephrology registry data for outpatient clinic; BMC Nephrology; [Published on 07/07/2016]; [Accessed on 23/11/2023] https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-016-0281-z
3. Arun Sharma et al.; Rationale of α-Ketoanalogue Supplemented with Low Protein Diet for the Treatment of Chronic Kidney Disease; Journal of Karnali Academy of Health Sciences; [Published on 09/01/2021]; [Accessed on 23/11/2023]; https://jkahs.org.np/jkahs/index.php/jkahs/article/view/415/222
4. Che-Hsiung Wu et al.; Ketoanalogues supplementation decreases dialysis and mortality risk in patients with anemic advanced chronic kidney disease; [Published on 05/05/2021]; [Accessed on 23/11/2023]; http://www.ncbi.nlm.nih.gov/pmc/articles/pmc5419544/

The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.