MACITENTAN

Written By:P. Thirumal ReddyB. Pharm Reviewed By:Dr. Tejashwin AdigaMBBS

Last updated on 31 Mar 2026 | 09:30 AM (IST)

MACITENTAN

Background and Date of approval MACITENTAN

The U.S. FDA approved macitentan on Oct 18, 2013. It is used to treat long-term treatment of pulmonary arterial hypertension (high blood pressure in the arteries) in adults.

Uses of MACITENTAN

It is used to treat long-term treatment of pulmonary arterial hypertension (high blood pressure in the arteries) in adults. It can be used alone or along with other medicines for PAH.

How is MACITENTAN administered?

Take macitentan tablets are available as 10mg tablets which can be consumed orally. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition.

Side Effects of MACITENTAN

The common side effects that are experienced while you are on the treatment with macitentan are anaemia, headache, bronchitis, nasopharyngitis, oedema, pharyngitis, urinary tract infection, hypotension, nasal congestion, and flushing.

Warnings

Consult your doctor if you are allergic to macitentan or have a liver or lung disorder. Consult your doctor if you are planning to get pregnant or think you may be pregnant or while breastfeeding, and it may cause infertility in males.

Precautions

The safety and effectiveness of the drug have not been established in children , hence it is not recommended in children. Speak with your doctor about your medical history to the doctor before taking this medicine.

Word of Advice

Your doctor may monitor your liver function and blood level, as this medicine may reduce red blood cells and alter the liver enzyme. Individuals with lactose intolerance or soy allergy should inform their doctor before taking the medicine. Kidney patients should be cautious and inform your doctor before taking medicine, as this may cause a reduction in blood pressure and hemoglobin levels. Inform your doctor, if you are allergic to black pepper (piperine).

Frequently Asked Questions

Q1.

What are the precautions I need to take while taking macitentan?

Inform your medical history to the doctor. It will be useful for him to treat you based on your health. Inform your doctor if you have kidney, liver, or lung disease before starting using the medicine.

Q2.

What are things I should be cautious about macitentan?

Individuals who have lactose intolerance or are allergic to soy should inform their doctor before taking the medicine.

Q3.

What happens if a pregnant woman takes macitentan?

It is not recommended for pregnant women, as it may cause undesirable effects if used during the period of pregnancy.

Q4.

Is there a specific monitoring schedule or tests I must undergo while taking macitentan?

You may be advised to monitor your liver function and blood level, as this medicine may reduce red blood cells and alter the liver enzyme.

Q5.

Can I drive while taking a macitentan?

It may cause headaches, tiredness, or drowsiness, which alters your driving ability. So, it is advised to consult your doctor before handling heavy machines or vehicles.

References

Janssen Pharmaceutica NV., Electronics Medicines Compendium (EMC), [Revised on Jan 2023], [ Accessed on 18 Oct 2023],https://www.medicines.org.uk/emc/files/pil.5223.pdf
Actelion Pharmaceuticals US, Inc., Food and Drug administration, [Revised on Oct 2018], [Accessed on Oct 18 2023],https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/204410s017lbl.pdf
KD Tripathi, Essentials of Medical Pharmacology, Androgens and drugs for erectile dysfunction, 7th edition, 2013, 296-300.

Disclaimer

The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.

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