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Author Details

Written By
P. Thirumal Reddy
B. Pharm

Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 26 Sep 2026 | 08:41 AM (IST)

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Quick Summary
STREPTOCOCCUS THERMOPHILUS,LACTOBACILLUS ACIDOPHILUS,BIFIDOBACTERIUM LONGUM,FRUCTO-OLIGOSACCHARIDES
Last updated on 26 Sep 2026 | 08:41 AM (IST)
STREPTOCOCCUS THERMOPHILUS,LACTOBACILLUS ACIDOPHILUS,BIFIDOBACTERIUM LONGUM,FRUCTO-OLIGOSACCHARIDES
Background and Date of Approval
This formulation combines probiotic strains—Streptococcus thermophilus, Lactobacillus acidophilus, and Bifidobacterium longum—with Fructo-oligosaccharides (FOS), a prebiotic that promotes the growth of healthy gut bacteria. Together, they work as a synbiotic, helping to restore gut balance, support digestion, and enhance immune health.
Since this is classified as a nutraceutical or dietary supplement, it is generally not subject to formal drug approval processes like those required for pharmaceutical medicines. Regulatory bodies such as the FSSAI in India or FDA in the US oversee its safety and labeling when marketed as a food supplement, not as a drug. Manufacturers must comply with quality and safety standards, but a specific “date of approval” is not applicable unless it’s part of a therapeutic or prescription formulation.
Uses
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Treatment of Chronic kidney disease
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Reduce antibiotic-associated diarrhea
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Decrease symptoms of irritable bowel syndrome (IBS)
How It Is Administered
- Route: Taken orally as a capsule, tablet, powder sachet, or chewable.
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Timing: Usually taken once or twice a day, preferably after meals.
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Powder Form: Mix with cool or room temperature water, juice, or soft foods. Do not use hot liquids, as heat can damage live bacteria.
- Storage: Keep in a cool, dry place, or refrigerate if recommended. Avoid moisture, direct sunlight, and high temperatures
Side Effects
Side Effects are unwanted symptoms caused by medicines. Although all medicines cause side effects, not everyone gets them.
Common
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Flatulence
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Nausea
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Bloating
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Stomach cramps
Warnings
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Should not be used in individuals with severely weakened immune systems, unless recommended by a doctor.
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Avoid in those with central venous catheters or heart valve disease, due to rare but possible infection risks.
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People with milk, soy, or lactose allergies should check the label, as some formulations may contain allergens.
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Always consult a doctor before use if pregnant, breastfeeding, or managing chronic illnesses.
Precautions
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Take this supplement with caution if you have ongoing liver, kidney, or gastrointestinal conditions.
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It is advisable to space the dose at least 2 hours apart from antibiotics, as these may reduce the effectiveness of probiotics.
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Discontinue use and consult a doctor if symptoms like bloating, gas, or discomfort persist.
Quick Tips
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Take ample rest because resting allows your body to recover and conserve energy during episodes of diarrhea.
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Drink plenty of fluids to compensate for the electrolyte loss caused by diarrhea. Water, clear broths, and oral rehydration solutions (ORS) can be beneficial in maintaining hydration and electrolyte balance.
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Avoid consuming contaminated food or water.
FAQs
Q1.
Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium longum, fructo-oligosaccharides works by metabolizing nitrogenous waste materials, inhibits the growth of pathogenic germs and enhances the overall quality of life.
Q2.
Yes, it can cause various side effects, especially when used for prolonged periods or at high doses. Some common side effects include nausea, soft stools, bloating, flatulence (gas), and stomach cramps.
Q3.
Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium longum, fructo-oligosaccharides is commonly prescribed to treat many conditions, including treatment of chronic kidney disease, reduce antibiotic-associated diarrhea, and decrease the symptoms of irritable bowel syndrome (IBS).
Q4.
It is recommended to store Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium longum, fructo-oligosaccharides in a cool, dry place, away from sunlight and moisture. Some medications may require refrigeration. It is important to read and follow the storage instructions to maintain the medication's stability and efficacy.
Q5.
Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium longum, fructo-oligosaccharides is usually taken orally as a capsule. The duration and dosage of treatment will depend on the patient's specific condition. It is important to follow the instructions and stay within the prescribed dose.
References
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Product description - HOSPIMAX. Accessed on 05/07/2023, http://www.hospimax.com/formulation/Detoxiren%20website%20content.pdf
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Probiotics and Prebiotics - World Gastroenterology Organisation, Accessed on 05/07/2023, https://www.worldgastroenterology.org/UserFiles/file/guidelines/probiotics-and-prebiotics-english-2017.pdf
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Tina Didari et al.; Effectiveness of probiotics in irritable bowel syndrome: An updated systematic review with meta-analysis; World Journal of Gastroenterology; Published on March 2015; Accessed on 05/07/2023; http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4356930/
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Naflesia B O Correa et al.; A randomized formula-controlled trial of Bifidobacterium lactis and Streptococcus thermophilus for prevention of antibiotic-associated diarrhea in infants; Journal of Clinical Gastroenterology; Published on June 2005; Accessed on 05/07/2023; https://pubmed.ncbi.nlm.nih.gov/15815206/
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Paola Vitellio et al; Effects of Bifidobacterium longum and Lactobacillus rhamnosus on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study; Published on April 2019; Accessed on 05/07/2023; Nutrients; http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6520754/
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AA Amara, A Shibl; Role of Probiotics in health improvement, infection control, and disease treatment and management; Saudi Pharmaceutical Journal; Published on 18 July 2013; Accessed on 05/07/2023; https://www.ncbi.nlm.nih.gov/pubmed/25972729
Disclaimer
The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.






