Amphosurge 50 uses: 

• Suspected fungal infections

• Visceral leishmaniasis

Liposomal Amphotericin B binds primarily to ergosterol in sensitive fungi cell membranes, causing membrane permeability changes that result in leakage of intracellular contents and cell death. 

1. Nephrotoxic Drugs (Severe)
   Using Amphosurge with medicines like aminoglycosides (amikacin, gentamicin), vancomycin, or cyclosporine can greatly increase the risk of kidney damage. Kidney function should be closely monitored.

2. Loop Diuretics (Severe)
   Drugs such as furosemide can amplify Amphosurge’s nephrotoxic and electrolyte-altering effects. Use together only under strict medical supervision.

3. Corticosteroids (Moderate)
   Steroids may worsen electrolyte disturbances (especially potassium and magnesium) caused by Amphosurge. Medical supervision is recommended if both are used.

4. Digoxin (Moderate)
   Low potassium levels caused by Amphosurge can increase the risk of digoxin toxicity. Electrolytes and digoxin levels should be monitored.

5. Flucytosine (Moderate)
   Using Amphosurge with flucytosine may increase antifungal effectiveness but also raises the risk of toxicity. Dose adjustments may be required.

6. Other Nephrotoxic or Electrolyte-Affecting Drugs (Moderate)
   Concurrent use with drugs that affect kidney function or electrolytes should be monitored carefully to prevent complications.

• Do not store above 25°C)

• Keep the injection away from the reach of children and pets.

• If you have missed any dosing appointments, inform your doctor and schedule immediately.

A doctor or nurse in a hospital or clinic setting will give it to you. It is given as an intravenous infusion drip (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.

Amphosurge 50 side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Common: 

• Skin rash

• Increased blood sugar levels

• Decreased potassium levels

• Diarrhea

• Nausea, vomiting

• Anemia

• Insomnia

• Shortness of breath

• Fever, chills or shivering

Serious:

• Cardia arrest

• GI bleeding

• Severe skin reactions

• Acute kidney injury

• This medicine may affect kidney function. Inform your doctor of any existing kidney problems before starting treatment.

• Watch for signs of severe infusion reactions such as flushing, itching, nausea, swelling of the face or mouth, difficulty breathing, or tightness in the chest. Seek medical help immediately if you experience any of these symptoms.

• For some infections, the medication may need to be taken for several weeks or months.

• Do not stop the treatment early, even if you start to feel better, as this may cause the infection to return.

• If your symptoms persist or worsen, inform your doctor promptly for further evaluation.