Orampho 50mg Injection contains the active substance Liposomal Amphotericin B. It is an antifungal antibiotic. It is used to treat fungal infections of one or more deep body organs. It is also used to treat suspected fungal infections in patients with a raised temperature and neutropenia (reduced number of white blood cells). It is also indicated to treat visceral leishmaniasis, a disease caused by a parasite in certain people.  

Before initiating your first treatment, your physician may give you a small amount of Orampho 50mg Injection to check for allergic reactions. Do not receive this injection if you are allergic to amphotericin B or any of the other ingredients in the medicine. Inform your physician if you have a severe allergic reaction, kidney or liver problems, and if you are having dialysis. Tell your doctor if you have low potassium levels. 

Orampho 50mg Injection contains sugar in each vial; tell your doctor if you have diabetes. Inform your physician if you are pregnant or breastfeeding before initiating the treatment. The most common side effects of Orampho 50mg Injection are skin rash, low potassium levels, diarrhea, anemia, insomnia, and shortness of breath. This medicine is not recommended for babies under 1 month old.

• Fungal infections of one or more deep organs of the body

• Suspected fungal infections

• Visceral leishmaniasis

Liposomal Amphotericin B binds primarily to ergosterol in sensitive fungi cell membranes, causing membrane permeability changes that result in leakage of intracellular contents and cell death.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, recent vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Orampho 50mg Injection and reduce its effectiveness by causing undesirable side effects.

• Do not store above (25°C)

• keep the injection away from the reach of children and pets.

• If you have missed any dosing appointments, inform your doctor and schedule immediately.

A doctor or nurse in a hospital or clinic setting will give it to you. It is given as an intravenous infusion drip (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Common: 

• Skin rash

• Increased blood sugar levels

• Decreased potassium levels

• Diarrhea

• Nausea, vomiting

• Anemia

• Insomnia

• Shortness of breath

• Fever, chills or shivering

Serious:

• Cardia arrest

• GI bleeding

• Severe skin reactions

• Acute kidney injury

• This medicine may affect kidney function. Inform your doctor if you have any existing kidney problems before starting treatment.

• Watch for signs of severe infusion reactions such as flushing, itching, nausea, swelling of the face or mouth, difficulty breathing, or tightness in the chest. Seek medical help immediately if you experience any of these symptoms.

• For some infections, the medication may need to be taken for several weeks or months.

• Do not stop the treatment early, even if you start to feel better, as this may cause the infection to return.

• If your symptoms persist or worsen, inform your doctor promptly for further evaluation.