Apigat 2.5mg uses are:

• Prophylaxis of Deep vein thrombosis (DVT)

• Prevent blood clots

It is a direct oral anticoagulant (DOAC) that works by inhibiting the activity of factor Xa, which is a protein involved in the blood clotting process. Specifically, this drug binds to the active site of factor Xa and blocks its ability to convert prothrombin to thrombin. Thus, preventing the formation of blood clots.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Apigat 2.5mg tablet and reduce effectiveness by causing undesirable side effects.

• Store Apigat 2.5mg tablet at a controlled room temperature(20°C to 25°C).
• Keep it out of reach from children.

Your doctor will decide the dose and duration of Apigat 2.5mg tablet based on the disease condition. Always take this medicine as prescribed by your doctor. The recommended starting oral dose of apixaban is 2.5 mg twice daily. Take the tablet at the same time every day, with or without food. Do not chew, crush, or break the tablet. Swallow the whole tablet with water. If you forgot to take the tablet, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten Apigat 2.5mg dosage.

Apigat 2.5mg side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. 

Serious

• Allergic reactions
• Abnormal liver function
• Low blood pressure, fainting
• Bleeding in vagina, stomach, nose, red stools.
• Allergic reactions like swelling in lips, face, throat.
• Bleeding in brain
   

Common

• Skin rash
• Hair loss
• Itching
• Reduced number of platelets

• Be cautious of injuries: Apigat 2.5mg tablet can increase the chances of bruising, so avoid using sharp objects or engaging in activities that may lead to cuts or injuries.

• Inform your doctor before procedures: Always notify your doctor before any medical procedures, including dental work or surgery, so proper precautions can be taken.

• Disclose all medications: Let your doctor know about any other medications, including over-the-counter drugs, supplements, or herbal remedies, to avoid interactions.

• Maintain a high-fiber diet: Consistently include fiber-rich foods like fruits, vegetables, and whole grains to help regulate bowel movements.

• Reduce constipation risk: Proper fiber intake can prevent constipation, which may otherwise increase the likelihood of bleeding while on Apigat 2.5mg.

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2. Highlights of prescribing information; food and drug administration. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/211964s000lbl.pdf  [Accessed on 03/Apr/2023].
3. Annex I summary of Product Characteristics - European Medicines Agency; Available at: https://www.ema.europa.eu/en/documents/product-information/eliquis-epar-product-information_en.pdf [Accessed on 03/Apr/2023].
4. Katherine Victoria Hurst, John Matthew O’Callaghan and Ashok Handa; Quick reference guide to Apixaban; Published 2017 [Accessed on 03/Apr/2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513886/#__ffn_sectitle
5. SL Greig; Apixaban: A review in venous thromboembolism; [Published:2016] [Accessed on 03/Apr/2023] https://pubmed.ncbi.nlm.nih.gov/27653758/
6. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Modulation of Cardiovascular Function, 12th edition, 2011, 867.
7. Bertram.G.Katzung, Basic and Clinical Pharmacology, Drugs Used to Treat Diseases of the Blood, Inflammation, & Gout, 14th edition, 617.