BEEDAN 20MG TABLET

Introduction:

Beedan 20mg Tablet consists of the active ingredient Dasatinib. It is prescribed for adults and children above one year of age with Chronic Myeloid Leukemia. This medicine is used to treat newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in the chronic phase and Ph+ acute lymphoblastic leukemia in patients resistant to other therapies.  

Chronic Myeloid Leukemia refers to a type of blood cancer that makes the body produce too many white blood cells that happen due to alteration in the Philadelphia chromosome. The abnormality in this chromosome causes BCR and ABL gene to fuse together and this fusion of genes influences multiplication, division and survival of tumour cells.

Acute Lymphoblastic Leukemia is the most common form of blood cancer that affects children. In this case, the lymphocytes of white blood cells multiply too quickly and live too long.

Uses of Beedan 20mg Tablet:

Beedan 20mg Tablet is indicated for the following conditions:

• Children and adults with chronic myeloid leukemia.
• Adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with resistance to prior therapy.

How Beedan 20mg Tablet works:

Beedan 20mg Tablet inhibits the BCR ABL tyrosine kinase enzyme by binding at both active and inactive sites. It reduces the uncontrolled production of white blood cells and inhibits their growth.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

These tablets do not require any special storage conditions.

References:

1. Bristol-Myers Squibb Pharma, Electronic Medicines Compendium (EMC), [Revised on Nov 2021][Accessed on 18th Dec 2021], https://www.medicines.org.uk/emc/files/pil.7745.pdf
2. Bristol-Myers Squibb Company, [Revised on Dec 2018] [Accessed on 25th Jun 2021], https://packageinserts.bms.com/ppi/ppi_sprycel.pdf
3. H.G. Watson, J.I.O. Craig, L.M. Manson, Blood disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 989-1056.
4. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.

How to use Beedan 20mg Tablet:

Take the tablet with or without food at the same time each day.

Safety Advice:

Pregnancy:

This tablet could be harmful to an unborn baby. Inform your physician before starting this treatment if you are pregnant or think you might be pregnant. 

Breastfeeding: 

Talk to your physician before breastfeeding while on this treatment. Your physician might advise you to stop breastfeeding during this course of treatment.

Liver:

Inform your physician before starting this treatment if you have liver diseases. Your physician will prescribe a dose accordingly.

Kidney:

Inform your physician before starting this treatment if you have kidney diseases. Your physician will prescribe a dose accordingly.

Driving: 

Avoid driving or using machinery if you experience side effects.

Others:

• This medicine may cause an abnormal heart rate, heart problems or a heart attack. Your physician will monitor the potassium and magnesium levels in your blood and your heart function.
• Inform your physician if you experience allergic reactions to Dasatinib or its ingredients.
• Inform your physician before starting this treatment if you have problems with your immune system.
• This medicine could cause a severe reduction in the number of platelets, WBC or RBC in the blood. Ensure that your physician monitors your blood levels at regular intervals.
• Inform your physician if you are lactose intolerant, have low potassium, magnesium levels in the blood, or have a flawed immune system.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Unusual bleeding or bruising
• Rapid heart rate
• Changes in consciousness or speech
• Breathlessness and swelling all over the body
• Fever or signs of infection
• Fluid retention
• Heart problems
• Myelosuppression
• Severe allergic reaction

Common:

• Diarrhea
• Headache
• Cough
• Rash
• Nausea, tiredness, vomiting
• Muscle pain, weakness
• Low appetite
• High or low BP