Bruzoi 100mg Capsule may be prescribed for:

• Chronic lymphocytic leukaemia (CLL).

• Small lymphocytic lymphoma (SLL).

• Mantle cell lymphoma (MCL), where indicated.

The appropriate treatment depends on the type of cancer, its stage, previous treatments and the patient's overall health. Follow your specialist's advice regarding its use.

Bruzoi 100mg Capsule contains acalabrutinib, which blocks the activity of Bruton's tyrosine kinase (BTK). This protein is involved in B-cell signalling and helps certain cancerous B-cells survive and multiply.

By inhibiting BTK, acalabrutinib interferes with these signals, helping slow the progression of specific blood cancers.

Bruzoi 100mg Capsule may interact with other medicines, potentially affecting its effectiveness or increasing the risk of side effects.

Inform your doctor about all medicines, supplements and herbal products you take, particularly:

• Anticoagulants and antiplatelet medicines: These may increase the risk of bleeding when taken with acalabrutinib.

• Antifungal medicines and certain antibiotics: Some can increase acalabrutinib levels in the body and may raise the risk of side effects.

• Medicines that affect CYP3A enzymes: Certain medicines can increase or decrease acalabrutinib levels, affecting its safety or effectiveness.

• Medicines that reduce stomach acid: Proton pump inhibitors, H2-receptor antagonists and antacids may affect the absorption of some acalabrutinib formulations.

Do not start, stop or change any medicine without consulting your doctor. Your doctor may need to adjust your treatment or recommend an alternative.

• Store Bruzoi 100mg Capsule according to the instructions on its packaging.

• Keep it in its original packaging and protect it from moisture.

• Keep it out of the reach of children.

• Do not use the medicine after its expiry date.

• Take Bruzoi 100mg Capsule exactly as prescribed by your doctor.

• Swallow the capsule whole with water. Do not open, crush or chew it.

• Follow your prescribed dosing schedule and take it at the recommended times.

• If you miss a dose, follow your doctor's or pharmacist's instructions. Do not take an extra dose to make up for a missed dose.

• Do not stop treatment or change your dose without medical advice.

Your doctor may recommend regular blood tests and other assessments to monitor your response to treatment and identify possible side effects.

Bruzoi 100mg Capsule may cause side effects, although not everyone experiences them.

Common side effects may include:

• Headache.

• Diarrhoea.

• Muscle or joint pain.

• Fatigue.

• Upper respiratory tract infections.

• Bruising or bleeding more easily.

Serious side effects that require medical attention include:

• Unusual or persistent bleeding.

• Fever or other signs of a serious infection.

• An irregular heartbeat, palpitations or fainting.

• Unexplained bruising or signs of low blood-cell counts.

• Yellowing of the skin or eyes, dark urine or other possible signs of liver problems.

Contact your doctor promptly if you develop unusual symptoms. Seek urgent medical attention for severe bleeding, serious breathing difficulty, fainting or other severe symptoms.

• Attend regular check-ups: Your doctor may recommend blood tests to monitor blood-cell counts and assess your response to treatment.

• Report bleeding promptly: Inform your doctor about unusual bruising, persistent nosebleeds, blood in your urine or black stools.

• Watch for infections: Contact your doctor if you develop a fever or other signs of infection.

• Check before taking other medicines: Consult your doctor or pharmacist before starting new medicines, supplements or herbal products.

• Protect your skin: Use sun protection and report unusual or persistent skin changes, as treatment with BTK inhibitors has been associated with an increased risk of certain other cancers.

• Follow your treatment plan: Do not change your dose or stop treatment without your specialist's advice.