Carfimib 60mg Injection is used to treat

• Treatment of multiple myeloma

Carfimib 60mg Injection is a proteasome inhibitor, which means it works by blocking the action of proteasomes, the enzymes responsible for breaking down proteins in cells. By blocking proteasomes, this medication can prevent the growth and survival of cancer cells, ultimately leading to the death of cancer cells. This can help to slow or stop the progression of multiple myeloma and may improve survival rates for some patients.

Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Carfimib 60mg Injection and reduce effectiveness by causing undesirable side effects.

• Carfimib 60mg Injection should be stored under refrigeration between 2°C to 8°C (36°F to 46°F).
• Keep in the original package until it is ready to use.
• Should not be frozen.
• Discard any unused portion after 4 hours.

Carfimib 60mg Injection is typically administered as an intravenous (IV) injection in a hospital or clinical setting by a healthcare provider. The exact dosing and frequency of administration will depend on the specific condition being treated and other individual factors, such as the patient's age, weight, and overall health.

If a dose is missed, it's important to contact your healthcare provider as soon as possible to determine the appropriate course of action. Suppose the missed dose is discovered within a few hours of the scheduled time. In that case, your healthcare provider may recommend administering the missed dose as soon as possible while maintaining the usual interval between doses. However, if more than a few hours have passed since the missed dose, your healthcare provider may recommend skipping the missed dose and resuming the regular dosing schedule at the next scheduled time. It's important not to double up on doses to make up for a missed one.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Cardiac events such as heart failure, heart attack, or arrhythmias
• Blood clotting disorders or bleeding
• Acute kidney injury
• Lung damage or inflammation
• Infections
• Tumor lysis syndrome (a condition that can occur when cancer cells break down rapidly)

Common side:

• Fatigue
• Nausea and vomiting
• Diarrhea
• Low blood cell counts (anemia, low white blood cell count, low platelet count)
• Fever
• Headache
• Difficulty breathing or shortness of breath
• Cough
• Muscle weakness or pain
• Rash
• Back pain

It is important to take the Carfimib 60mg Injection as directed by a healthcare professional. Patients should also inform their doctor of any pre-existing medical conditions and any other medications they may be taking. It is important to be aware of the potential side effects of Carfimib 60mg Injection and to report any concerns to your healthcare provider. Finally, pregnant or breastfeeding women should consult their doctor before taking Carfimib 60mg Injection, as the drug may pose a risk to the baby.

There are no specific dietary restrictions for patients taking Carfimib 60mg Injection. However, it is generally recommended that patients with cancer maintain a healthy and balanced diet to support their overall health and well-being. Drinking plenty of water and other fluids, such as clear broths or herbal teas, can help to prevent dehydration.

1. Amgen Limited, Electronic medicines compendium (EMC), [Revised on August 2021] [ Accessed on 13th April 2023], https://www.medicines.org.uk/emc/files/pil.5061.pdf
2. Onyx Pharmaceuticals, Inc, US Food and Drug Administration, [Revised on Feb 2019] [ Accessed on 13th April 2023], 
3. Anderson KC, Munshi NC. Hematologic Malignancies: Multiple Myeloma and Related Plasma Cell Disorders. New York: Springer; 2019.
4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/202714s025lbl.pdf
5. Kimberly Redic; Carfilzomib: A novel agent for multiple myeloma; The Journal of Pharmacy and Pharmacology, [ Revised on Aug 2013], [Accessed on 13th April 2023] https://pubmed.ncbi.nlm.nih.gov/23837578/