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Pregnancy and Breastfeeding: Certican 0.5mg tablets can harm an unborn baby. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Use effective birth control during treatment and for 8 weeks after your last dose.
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Monitoring and Tests: Your healthcare provider will perform a pregnancy test before starting treatment and may schedule regular follow-ups and blood tests to monitor your health.
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Mouth Sores: Mouth ulcers or sores are common. Use the prescribed mouthwash as directed to prevent and manage these symptoms.
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Safety and Precautions: Take the medicine exactly as prescribed, avoid self-medicating, report side effects or infections promptly, and follow all safety instructions provided by your healthcare provider.
Quick Summary
Certican 0.5mg Tablet
Written By:Dr. B. DeivaPharm D Reviewed By:Dr. Tejashwin AdigaMBBS
Last updated on 31 Mar 2026 | 09:31 AM (IST)
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Introduction
Certican 0.5mg tablet is an antineoplastic drug belonging to the class of mTOR kinase inhibitors, containing the active ingredient everolimus. It is used to treat advanced breast cancer, renal cell carcinoma, pancreatic neuroendocrine tumours, and also in the treatment of subependymal giant cell astrocytoma (tumours are found in the ventricles of the brain). Good oral hygiene and regular dental check-ups are important during the treatment since this medicine can cause sores or ulcers in the mouth. It is often combined with cyclophosphamide, an alkylating agent, to treat subependymal giant cell astrocytoma.
Before taking this medicine, it is necessary to know that your risk of getting bacterial or viral infection increases with this treatment. If you have been infected with Hepatitis B, Certican 0.5mg tablet increases the chances of reinfection. Tell your healthcare provider if you experience fever, chills, cough, yellowing of the skin, joint pain, or swelling during this treatment. You must limit your exposure to sunlight and UV light by wearing protective clothing and applying sunscreen frequently, as this medicine may increase the risk of developing cancers. Avoid taking grapefruit juice or grapefruit while taking this medicine. Some one-line for Certican substitutes include Everolimus and Sirolimus, but always consult your doctor before switching medications.
This tablet is not recommended for adolescents and children under the age of 18. Contact your doctor immediately if you experience shortness of breath, chest pain, or worsening cough. During the Certican 0.5mg tablet treatment, your doctor may periodically monitor your white blood cell counts, platelets, blood sugar, electrolytes, and kidney parameters to prevent serious complications. This medicine has the potential to cause kidney problems. Report to your doctor if you have been diagnosed with liver disorders, heart failure, high blood cholesterol levels, or hypertension before starting this treatment. Avoid live vaccines and close contact with those who have received live vaccines. Certican price is based on the seller and Place.
Uses
Certican uses are:
- Advanced breast cancer
- Advanced renal cell carcinoma
- Advanced pancreatic neuroendocrine tumours
- Treatment of subependymal giant cell astrocytoma
How Certican 0.5mg Tablet Works
Certican 0.5mg tablet inhibits the activity of a protein called mammalian target of rapamycin (mTOR), which regulates cell growth. This drug can slow the growth of abnormal cancer cells by blocking the mTOR protein and helps to reduce the size of tumours and improve outcomes in patients.
Interaction of Certican 0.5mg Tablet with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Certican 0.5mg tablet and reduce effectiveness by causing undesirable side effects.
Storage Conditions
- Store Certican 0.5mg tablet in the original package at room temperature (20°C to 25°C).
- Keep it out of reach from children.
How to take Certican 0.5mg Tablet
Take the Certican 0.5mg tablet as advised by your physician. Do not crush, chew, or open the medicine. Your physician will decide the correct Certican dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.
Safety Advice for Certican 0.5mg Tablet
Breast Feeding
Unsafe
Certican 0.5mg tablet passes into your breast milk and harms your baby. It is unsafe to consume this tablet.
Alcohol
Unsafe
Consuming alcohol may affect the effectiveness of Certican 0.5mg tablet. Stop consuming alcohol if you are taking this medicine.
Liver
Consult Your Doctor
Inform your doctor if you have any liver problems before taking Certican 0.5mg tablet. Regular monitoring of liver function tests is recommended.
Lungs
Consult Your Doctor
It is not known whether Certican 0.5mg tablet can be used for patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
Driving
Unsafe
It is unsafe to drive vehicles or operate heavy machinery after taking Certican 0.5mg tablet, it may cause dizziness and impair your concentration.
Pregnancy
Unsafe
Certican 0.5mg tablet is not recommended for pregnant women as it may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.
Side Effects
Certican side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Difficulty breathing, or swallowing
- Swelling of face, lips, tongue, throat
- Severe itching, red rash, raised bumps
Common
- Infection (chills, increased temperature)
- Coughing
- Wheezing
- Excessive thirst
- High urine output or severely decreased urine output
- Tiredness
- Bleeding
- Increased appetite with weight loss
Expert tips
FAQs about Certican 0.5mg Tablet
Q1.
What you should know before taking Certican 0.5mg tablet?
Before taking Certican 0.5mg tablet, it is important to know that your risk of getting bacterial or viral infection increases with this treatment. If you have been infected with Hepatitis B, this drug increases the chances of reinfection. Tell your healthcare provider if you experience fever, chills, cough, yellowing of the skin, joint pain, or swelling during this treatment.
Q2.
Is it safe to use Certican 0.5mg tablet during pregnancy?
Certican 0.5mg tablets have the tendency to cause harm to the unborn fetus. Inform your healthcare provider before starting this treatment if you are pregnant, or planning for pregnancy. Your healthcare provider will conduct a pregnancy test before you start treatment with this drug.
Q3.
What are the side effects of Certican 0.5mg Tablet?
The common side effects that are likely to occur while you are on the treatment with Certican 0.5mg tablet are fever, chills, skin rash, joint pain, swelling, tiredness, loss of appetite, high risk of infection, mouth ulcers, and difficulty breathing.
Q4.
Is it safe to undergo surgery while on treatment with Certican 0.5mg tablet?
Certican 0.5mg tablet may lead to poor wound healing ability. Consult your healthcare provider and stop taking this tablet at least one week before planned surgery.
Q5.
Can I drink alcohol while taking Certican 0.5mg tablet?
It is generally recommended to avoid drinking alcohol while taking Certican 0.5mg tablet, as alcohol can increase the risk of liver damage.
Fact Box
|
Molecule name: Everolimus |
|
|
Therapeutic class: |
Antineoplastics |
|
Pharmacological class: |
mTOR kinase inhibitors |
|
Indications: |
1. Advanced breast cancer 2. Advanced renal cell carcinoma 3. Advanced pancreatic neuroendocrine tumors 4. Treatment of subependymal giant cell astrocytoma |
References
- Novartis Pharmaceuticals UK Limited, Electronic medicines compendium (EMC), [ Revised on June 2022] [ Accessed on 18th March 2023], https://www.medicines.org.uk/emc/files/pil.6658.pdf
- Jan Hasskarl; Everolimus; Recent Results in Cancer Research; Published on 2018; Accessed on 18/03/2023; https://pubmed.ncbi.nlm.nih.gov/30069763/
- Novartis Pharmaceuticals Corporation, US Food and Drug Administration, [ Revised on July 2012] [ Accessed on 18th March 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022334s016lbl.pdf
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Targeted therapy: tyrosine kinase inhibitors, monoclonal antibodies, and cytokines, 12th edition, 2011, 1743.
- KD Tripathi, Essentials of Medical Pharmacology, Immunosuppressant drugs, 7th edition, 2013, 878 - 882.
Disclaimer
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Author Details
Written By
Dr. B. Deiva
Pharm D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:31 AM (IST)
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