Cyramza 100mg Injection is an anticancer medication containing the active ingredient Ramucirumab. It is a monoclonal antibody drug. Cancer is a condition in which cells multiply uncontrolled and abnormally. This medication treats advanced cancers of the stomach, colon, rectum, lungs, and liver. It may be given alone or in combination with other anticancer medications to treat various types of cancer. The benefits of Cyramza 100mg Injection are that it can help to slow down the growth and spread of cancer cells in various types of cancer. Studies have shown that this medication can improve survival rates and increase the time until cancer progresses to the advanced stage.

As with any medication, Cyramza 100mg Injection can cause side effects, including high blood pressure, fatigue, nausea, vomiting, and diarrhea. Inform your doctor if you have high blood pressure, bleeding problems, liver disorders, kidney disorders, lung cancer, or are going to have surgery before taking this medication. This medication is not recommended for adolescents and children under 18.

• Advanced gastric cancer
• Gastroesophageal junction adenocarcinoma
• Non-small cell lung cancer
• Hepatocellular carcinoma
• Colorectal cancer

Ramucirumab is a monoclonal antibody drug used in the treatment of various types of cancer. It works by targeting and inhibiting the action of a protein called vascular endothelial growth factor receptor 2 (VEGFR2), which plays a key role in the growth and development of blood vessels that feed tumours. By blocking VEGFR2, this medication prevents cancer cell growth and spread.

You should tell the doctor about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Cyramza 100mg Injection and reduce effectiveness by causing undesirable side effects.

• Cyramza 100mg Injection should be stored according to the manufacturer's instructions and in compliance with local regulations.
• Stored in a refrigerator at a temperature between 2°C and 8°C (36°F and 46°F).
• Do not freeze or shake the drug.
• Keep in its original packaging until ready to use.
• After reconstitution, use immediately or within 4 hours if stored at room temperature or within 24 hours if stored in a refrigerator.

Cyramza 100mg Injection is administered by a healthcare professional through intravenous injection in a hospital or clinic setting. It is not intended for self-administration. The recommended dosage and frequency depends on the type and stage of the cancer being treated, the individual patient's medical history, and overall health status. The drug is usually administered with chemotherapy or as a standalone treatment.

If you miss a scheduled dose, contact your healthcare provider as soon as possible to discuss the best course of action. Sometimes, your healthcare provider may recommend that you receive the missed dose as soon as possible and then resume the regular dosing schedule. However, this will depend on several factors, such as how long it has been since your last dose, overall health status, and cancer stage. It is important not to double the dose to make up for a missed dose, as this can increase the risk of side effects.

Side effects are unwanted symptoms that occur due to medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Blood clots
• Impaired wound healing
• Serious infusion reactions
• Kidney problems
• Hepatotoxicity (liver damage)
• Pulmonary hemorrhage (bleeding from the lungs)

Common:

• High blood pressure
• Fatigue
• Decreased appetite
• Nausea and vomiting
• Diarrhea
• Mouth sores
• Abdominal pain
• Headache
• Proteinuria (the presence of excess protein in the urine)
• Hypothyroidism (an underactive thyroid gland)
• Gastrointestinal bleeding
• Nosebleeds
• Bruising

If you are considering Cyramza 100mg Injection for cancer treatment, it is important to weigh the potential benefits against the risks and side effects and to discuss any concerns with your healthcare provider. While this medication can be an effective treatment option for certain types of cancer, it does come with some potential risks and precautions that should be carefully considered. This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury.  Maintain a healthy lifestyle to support your overall health and well-being during treatment. 

If you are pregnant or breastfeeding, discussing the potential risks and benefits of this medication with your healthcare provider before starting treatment is important. Effective contraception is recommended during treatment and at least 3 months after the last dose f this medication. Remember to communicate openly with your healthcare team and to seek support from loved ones and other resources as needed throughout your treatment journey.

1. Eli Lilly Nederland B.V, Electronic medicines compendium (emc), [Revised on July 2021] [ Accessed on 2nd Dec 2021], https://www.medicines.org.uk/emc/files/pil.3640.pdf
2. Eli Lilly and Company, US Food and Drug Administration, [Revised on May 2020] [ Accessed on 2nd Dec 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/125477s034lbl.pdf
3. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 13th edition, 2018, 1311-1312
4. Cancer Chemotherapy and Biotherapy: Principles and Practice, 5th edition, 2018, 777-779