DOXULIP 20MG INJECTION

Introduction:

Doxulip 20mg Injection is an anticancer medication that contains the active constituent doxorubicin encapsulated in a closed lipid sphere (liposome).  Cancer is a disease in which cells multiply in an uncontrolled and abnormal manner. This medication is used to treat breast cancer, ovarian cancer, multiple myeloma (cancer of white blood cell called plasma cell) and AIDS-related Kaposi’s sarcoma. 

People with HIV infection have the highest risk of Kaposi’s sarcoma (cancer that forms in the lining of the lymph and blood vessels). Doxulip 20mg Injection may be given alone or in combination with other anticancer medicines. This medication is not recommended for adolescents and children.

Use effective birth control during the treatment and for at least six months after the last dose. It is important to tell your doctor if you are allergic to peanuts or soya if you are receiving medicines for heart or liver disorders, have diabetes, Kaposi’s sarcoma or oral problems before taking Doxulip 20mg Injection.

Uses of Doxulip 20mg Injection:

• Breast cancer
• Ovarian cancer
• Multiple myeloma
• AIDS-related Kaposi’s sarcoma

How Doxulip 20mg Injection works:

Doxorubicin inhibits the activity of enzyme topoisomerase II, involved in the DNA (genetic material) multiplication of cancer cells. This prevents the growth and multiplication of cancer cells. 

The unique formulation process of Doxulip 20mg Injection increases the time this medicine is circulating in the blood. It also helps deliver drugs from blood to the cancerous tissue rather than healthy tissue.

Interactions with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More information:

• Keep Doxulip 20mg Injection out of sight and reach of children.
• Store refrigerated at 2°C - 8°C. Do not freeze.

References:

1. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Cytotoxic agents, 12th edition, 2011, 1714.
2. KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 867.
3. Baxter Holding BV, European medicines agency (ema), [Revised on May 2006] [ Accessed on 4th  Dec 2021], https://www.ema.europa.eu/en/documents/product-information/caelyx-pegylated-liposomal-epar-product-information_en.pdf
4. Ben Venue Laboratories, Inc, US Food and Drug Administration, [Revised on May 2007] [ Accessed on 4th Dec 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/050718s029lbl.pdf

How to use Doxulip 20mg Injection:

It will be given to you by a health care professional.

Safety advice:

Pregnancy:

Doxulip 20mg Injection may harm the unborn baby. You need to tell your physician if you are pregnant or planning to get pregnant before taking this medicine. 

Breastfeeding:

Stop breastfeeding before starting treatment with Doxulip 20mg Injection. You need to tell your physician if you are breastfeeding before taking this medicine. 

Liver:

You need to tell your physician if you have any liver disorders before taking Doxulip 20mg Injection.

Driving: 

Doxulip 20mg Injection may cause tiredness or sleepiness. Avoid driving if you are unwell.

Others:

Talk to your physician if:

• You have diabetes or Kaposi’s sarcoma.
• You are allergic to peanuts or soya.
• You notice discoloration, sores, or discomfort in the mouth.
• You are receiving medicines for heart disorders.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Serious:

• Fever, tiredness, bruising or bleeding
• Severe diarrhea, sores in mouth, nausea, vomiting
• Lung infections, shortness of breath
• Severe stomach pain
• Severe weakness

Common:

• Low blood cell counts
• Hair loss
• Decreased appetite
• Skin rashes
• Pain in the muscles and joints
• Constipation
• Feeling confused, difficulty sleeping
• Headache, dizziness, sleepiness
• Change in taste
• High or low blood pressure
• Excessive sweating
• Pain when passing urine
• Weight loss
• Muscle spasms
• Fast heartbeat