Encoxel 40mg Injection is used in the treatment of the following:

• Deep vein thrombosis
• Prophylaxis of venous thrombo-embolism
• Unstable angina
• ST-segment Elevation Myocardial Infarction (STEMI)
• Prevention of blood clots during surgeries

Encoxel 40mg Injection binds to the antithrombin to form a complex. Antithrombin is a protein that blocks the formation of abnormal blood clots. This drug mainly prevents the activation of factor Xa, eventually preventing clot formation. It is commonly used for the prevention and treatment of conditions associated with increased risk of blood clots.

Some medicinal products that affect haemostasis should be discontinued before starting Encoxel 40mg Injection therapy unless absolutely necessary. If a combination is required, Encoxel 40mg Injection should be used with careful clinical and laboratory monitoring. 

These products include systemic salicylates, acetylsalicylic acid at anti-inflammatory doses, NSAIDs like ketorolac, other thrombolytics such as alteplase, reteplase, streptokinase, tenecteplase, urokinase, and other anticoagulants. 

Always inform your doctor about any medicines or supplements you are taking, as they may interact with Encoxel 40mg Injection.

• Store Encoxel 40mg Injection below 25 °C.
• Do not freeze
• Keep it out of reach from children.
• Protect them from light and moisture.

Encoxel 40mg Injection will be administered to you by a healthcare professional in a hospital setting. It is usually administered as an intravenous injection into a vein. Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious side effects of Encoxel 40mg Injection are:

• Severe allergic reactions (swelling of lips, tongue, or throat, difficulty breathing, or swallowing)
• Too much bleeding (weakness, being pale, dizziness with headache, or unexplained swelling)
• Blockage of blood vessels (pain, redness, or swelling in the legs, or coughing up blood)
• Rash of dark red spots under the skin

Common side effects of Encoxel 40mg Injection are:

• Bleeding
• Bruising more easily
• Low blood cell counts
• Headache
• Itchy red skin
• Edema
• Pain at the injection site
• Pink patches on the skin

Encoxel 40mg Injection can cause bleeding and many undesirable side effects; hence it is advised to get adequate rest during the treatment. Eat a well-balanced diet. Apply a cool compress at the injection site to reduce pain and irritation. Encoxel 40mg Injection should not be stopped suddenly without first talking to your doctor because doing so may raise your risk of blood clots. 

Aspirin and other non-steroidal anti-inflammatory medicines (NSAIDs) may increase the risk of bleeding when combined with Encoxel 40mg Injection, so it is not recommended to take them without first talking to your doctor. Keep away from activities that put you at higher risk of bleeding or getting hurt, like contact sports and activities. 

Foods high in Vitamin K may have an impact on blood clotting and may interfere with the way anticoagulant drugs like Encoxel 40mg Injection. It is recommended to eat leafy green vegetables, asparagus, Brussels sprouts and soybean oil in moderation. It is advised to monitor your platelet count regularly.

1. Rovi Biotech Limited, European Medicine Consortium (EMC), [Revised on Nov 2018], Available at: https://www.medicines.org.uk/emc/files/pil.9330.pdf [Accessed on 27th May 2023].
2. Sanofi, [Revised on Apr 2022] [Accessed on 27th May 2023], https://products.sanofi.us/lovenox/lovenox.pdf
3. Clexane® syringes 100MG/ML solution for Injection - HPRA. [Revised on May 2022], Available at: https://www.hpra.ie/img/uploaded/swedocuments/7900ad74-3eb7-41a2-be4c-3b757cb841ec.pdf [Accessed on 27th May 2023].
4. KD Tripathi, Essentials of Medical Pharmacology, Drugs Affecting Coagulation, Bleeding and Thrombosis, 8th Edition, 2019, 659-681.