Endoxan 50mg Tablet is used for:

• Leukaemias: Helps treat certain blood cancers, including lymphocytic and myeloid leukaemias.

• Malignant lymphomas: Used in the treatment of cancers affecting the lymphatic system, including Hodgkin's lymphoma and non-Hodgkin's lymphoma.

• Breast cancer: May be used alone or alongside other anticancer medicines as part of a treatment regimen.

• Ovarian and testicular cancers: Used in selected treatment regimens for these cancers.

• Other solid tumours: May be prescribed for certain cancers, including small-cell lung cancer, neuroblastoma and Ewing's sarcoma.

• Certain autoimmune conditions: Cyclophosphamide may be prescribed in selected cases of severe immune-mediated conditions, such as systemic lupus erythematosus and certain types of vasculitis, when specialist treatment is required.

• Selected kidney conditions: Cyclophosphamide may be used for certain kidney disorders, including minimal change nephrotic syndrome in children, when indicated by a specialist.

The approved uses may vary according to the product's prescribing information and the patient's condition. The treating specialist determines whether Endoxan 50mg Tablet is appropriate, along with the dose and duration of treatment.

Endoxan 50mg Tablet contains Cyclophosphamide, an alkylating agent that damages the DNA of cells. This interferes with their ability to grow and multiply, helping to destroy cancer cells and slow the progression of certain cancers.

Cyclophosphamide also suppresses immune system activity. This effect can be useful in selected autoimmune conditions, where the immune system mistakenly attacks the body's own tissues. However, the medicine can also affect healthy cells, including those in the bone marrow, which is why regular medical monitoring is necessary during treatment.

Some medicines can change how Cyclophosphamide works or increase the risk of side effects. Tell your doctor about all prescription medicines, over-the-counter medicines, vitamins and herbal supplements you take.

• Other anticancer medicines: Combining Cyclophosphamide with certain chemotherapy medicines can increase the risk of low blood cell counts, infections and damage to organs such as the heart or lungs. Your specialist will adjust treatment and monitoring as needed.

• Medicines that affect liver enzymes: Medicines such as rifampicin, carbamazepine, phenytoin and phenobarbital can alter the way Cyclophosphamide is processed in the body and may affect its effectiveness or toxicity.

• Medicines that suppress the immune system: Combining Cyclophosphamide with other immunosuppressants can increase the risk of serious infections and other toxic effects.

• Warfarin: Cyclophosphamide may increase or decrease the anticoagulant effect of warfarin, potentially affecting bleeding risk. Closer monitoring may be required.

• Live vaccines: Cyclophosphamide can weaken immune responses, increasing the risk of infection from certain live vaccines. Discuss vaccination plans with your doctor before receiving any vaccine.

• Alcohol: Alcohol may worsen nausea and vomiting associated with Cyclophosphamide. Discuss alcohol consumption with your treating specialist during treatment.

• Store Endoxan 50mg Tablet at or below 25°C, following the instructions on the product packaging.

• Protect the tablets from moisture.

• Keep the medicine in its original packaging until it is needed.

• Keep it out of the sight and reach of children.

• Do not use the medicine after the expiry date printed on the packaging.

• Handle the tablets carefully because Cyclophosphamide is a cytotoxic medicine. Do not crush, split or chew the tablets.

• Take Endoxan 50mg Tablet exactly as prescribed by your specialist. The dose and treatment schedule depend on your condition, body size, general health, blood test results and other medicines used during treatment.

• The tablets are generally taken in the morning, according to the prescribed schedule.

• Drink adequate fluids during and immediately after taking the medicine, as advised by your doctor.

• Empty your bladder regularly throughout the day to help reduce the risk of bladder irritation.

• Swallow the tablet whole. Do not crush, chew or divide it, as this may expose you or others to the active substance.

• If you miss a dose, follow your doctor's instructions. Do not take an extra dose or double the next dose to make up for a missed one.

• Do not change the dose, interrupt treatment or stop taking the medicine without medical advice.

Endoxan 50mg Tablet may cause side effects in some people. Their severity can vary depending on the dose, treatment duration and other medicines used alongside it.

Common side effects

• Nausea and vomiting

• Loss of appetite

• Hair loss

• Mouth sores or inflammation of the mouth

• Diarrhoea

• Abdominal discomfort

• Tiredness or weakness

• Reduced blood cell counts

Serious side effects

Seek immediate medical attention if you experience any of the following:

• Severe infections: Fever, chills or other signs of infection may indicate a serious reduction in immune function.

• Unusual bleeding or bruising: This may occur if the medicine reduces platelet counts.

• Blood in the urine or painful urination: Cyclophosphamide can irritate or damage the bladder and urinary tract.

• Severe allergic reactions: Swelling of the face, lips, tongue or throat, or difficulty breathing, requires emergency medical attention.

• Liver problems: Yellowing of the skin or eyes may indicate liver injury.

• Breathing difficulties: Persistent coughing or shortness of breath may indicate lung complications.

• Take Endoxan 50mg Tablet only under the supervision of a specialist experienced in its use.

• Attend scheduled blood tests so your doctor can monitor blood cell counts and check for treatment-related complications.

• Drink adequate fluids as advised and empty your bladder regularly to help reduce the risk of bladder irritation.

• Report fever, chills, unusual bruising or bleeding, and signs of infection promptly.

• Tell your doctor about any kidney, liver, heart or lung conditions before starting treatment.

• Inform your healthcare team about all medicines, supplements and vaccines you use or plan to receive.

• Do not crush, chew or split the tablets. Handle them carefully and follow your pharmacist's instructions for safe handling.

• Discuss fertility preservation before starting treatment if you may want to have children in the future, as Cyclophosphamide can affect fertility.

• Use effective contraception as advised by your specialist during treatment and for the recommended period afterwards.

• Do not stop treatment or change the prescribed schedule without consulting your doctor.