Exetraz 25mg Tablet uses include:

• Treatment of early-stage hormone-dependent breast cancer in postmenopausal women

• Management of advanced or metastatic breast cancer in patients whose disease continues to progress after Tamoxifen therapy.

The active ingredient in Exetraz 25mg Tablet, Exemestane, works by inhibiting an enzyme called aromatase, which is responsible for converting androgens (male hormones) into estrogen (female hormones). By blocking this enzyme, the medication significantly reduces estrogen levels in the body. Since certain types of breast cancer cells rely on estrogen to grow and spread, lowering estrogen levels helps to slow down or stop the progression of hormone-sensitive breast cancer in postmenopausal women.

Before starting Exetraz 25mg Tablet 10'S, inform your doctor about all medicines you are currently taking, including:

• Antibiotics like Rifampicin

• Anti-epileptic medications such as Carbamazepine and Phenytoin

• Herbal products like St. John’s Wort

Drug interactions can reduce the effectiveness of Exetraz 25mg Tablet or increase the risk of side effects. Always disclose your full medication list, including over-the-counter supplements, to your healthcare provider.

• Storage: Keep at room temperature, away from light and moisture, in original packaging.
• Safety: Store out of reach of children and pets.
• Special Conditions: No refrigeration or special storage needed.
• Missed Dose: Take as soon as remembered or skip if close to the next dose—don’t double it.

• Take one tablet once daily, preferably after food.

• Swallow the tablet whole with water; do not crush or break it into pieces.

• Your doctor will decide the correct dose and treatment duration based on your medical condition and treatment response.

• If you miss a dose, skip it and continue with your next scheduled dose. Do not take a double dose.

Like all medications, Exetraz 25mg Tablet side effects can occur, but not everyone experiences them.

Common Side Effects:

• Nausea, diarrhea

• Joint pain, back pain

• Fatigue, weakness

• Hot flashes

• Abdominal pain

• Depression

• Swelling in hands or feet

• Muscle pain, tingling sensations

Serious Side Effects (Seek immediate medical help):

• Allergic reactions: Rash, itching, difficulty breathing

• Low white blood cell count (leukopenia)

• Low platelet count (thrombocytopenia)

• Elevated liver enzymes

• Severe bone loss (osteoporosis)

If you experience unusual symptoms or allergic reactions, contact your doctor immediately.

Before starting Exetraz 25mg Tablet, it is important to inform your doctor about your complete medical history, especially if you have liver or kidney problems or a history of bone-related conditions like osteoporosis. This medicine reduces estrogen levels, which can weaken your bones and increase the risk of fractures, so your doctor may recommend regular bone density tests and vitamin D monitoring. Always use effective contraception during treatment, as this medicine is not safe during pregnancy. Do not start, stop, or change your dose without consulting your healthcare provider. If you notice any unusual symptoms or side effects, seek medical advice promptly to ensure safe and effective treatment.

1. Zentiva Pharma UK limited, Electronic medicines compendium (EMC), [Revised on July 2022] [Accessed on 21st April 2023], Exemestane 25mg film-coated tablets - Patient Information Leaflet (PIL) - (emc) (medicines.org.uk)
2. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.