• Deep vein thrombosis (DVT)
• Pulmonary embolism (PE).
• Prevention of blood clots in medical setting

The mechanism of action of Fragmin 2500IU Injection involves its ability to bind to antithrombin III, a natural anticoagulant in the body. This binding enhances antithrombin III's ability to inactivate clotting factors, particularly factor Xa and, to a lesser extent, thrombin. By inhibiting these key clotting factors, this medication effectively prevents the formation of blood clots. It reduces the risk of thromboembolic events, such as deep vein thrombosis (DVT) and pulmonary embolism (PE).

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Fragmin 2500IU Injection, reducing effectiveness by causing undesirable side effects.

• Store at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep away from moisture, heat, and light.
• It should not be frozen.
• Keep away from children and pets.

Fragmin 2500IU Injection is typically administered as a subcutaneous injection (under the skin). The exact dosing and administration schedule will depend on the medical condition being treated, the patient's weight, and other individual factors. It is essential to follow the instructions provided by your healthcare professional or pharmacist carefully.

Fragmin 2500IU Injection causes some side effects like all medications, although not everyone will experience them. 

Serious:

• Signs of bleeding
• Black or bloody stools
• Coughing up blood or blood clots
• Severe headache or weakness, especially on one side of the body
• Sudden vision changes
• Severe abdominal or back pain
• Severe or persistent dizziness or fainting
• Signs of an allergic reaction, including rash, itching, swelling

Common:

• Bruising at the injection site
• Mild pain or redness at the injection site
• Bleeding from the gums or nose
• Mild stomach upset or nausea
• Mild headache
• Itching or skin rash

Before using Fragmin 2500IU Injection, inform your healthcare provider about any bleeding disorders, history of heparin-induced thrombocytopenia, kidney or liver impairment, and any ongoing medications or medical conditions. Be vigilant for signs of bleeding, such as easy bruising or prolonged bleeding from cuts, and report any severe or persistent side effects promptly. Caution is advised when undergoing spinal or epidural anesthesia, as Fragmin 2500IU Injection may increase the risk of spinal or epidural hematomas. Regular monitoring of blood clotting factors may be necessary, especially during surgery or invasive procedures. Avoid alcohol abuse, which can further increase bleeding risk. The use during pregnancy and breastfeeding should be carefully assessed, and if you are planning long-distance travel, consult your healthcare provider for travel-related precautions. Follow all healthcare provider's instructions and attend follow-up appointments to ensure safe and effective treatment with Fragmin 2500IU Injection.

1. KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting Coagulation, Bleeding and Thrombosis, 7th edition, 2013, 619.
2. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Blood coagulation and Anticoagulant, Fibrinolytic and Antiplatelet drugs, 12th edition, 2011, 858.
3. Pfizer, Electronic medicines compendium (EMC), [Revised on 22 Feb 2023] [Accessed on 30th July 20203], https://www.medicines.org.uk/emc/product/4247/pil#gref
4. Pfizer, US Food and Drug Administration, [ Revised on May 2019] [ Accessed on 30th July 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/020287s072lbl.pdf