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Graviparin 300mg Injection
Last updated on 31 Mar 2026 | 09:29 AM (IST)
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Introduction to Graviparin 300mg Injection
Graviparin 300mg Injection is an anticoagulant drug belonging to the category of low molecular weight heparin (LMWH). It contains the active ingredient Enoxaparin. It is used to treat severe blood clots. This drug also prevents the occurrence of deep vein thrombosis in abdominal surgery, hip replacement surgery, knee replacement surgery, and in people with severe movement restrictions. This injection prevents further heart complications in patients with unstable angina and non-Q wave myocardial infarction.
Graviparin 300mg Injection is not recommended for patients with active bleeding, hypersensitivity, or allergies to the active compound, as well as those with a history of heparin-induced thrombocytopenia, before taking Graviparin 300mg Injection, tell your physician if you are allergic to Enoxaparin, heparin, benzyl alcohol, or pork products.
Your healthcare provider will regularly monitor you for signs of bleeding. Inform your healthcare practitioner if you are diagnosed with kidney problems. It is not recommended for use in children and adolescents below 18 years.
Graviparin 300mg Injection is not recommended if you undergo procedures like neuraxial anaesthesia or spinal puncture. It is recommended to monitor older adults and patients with low weight for increased risk of bleeding.
Tell your physician if you suspect pregnancy, breastfeeding, or planning to have a baby. Graviparin 300mg Injection may increase the chance of bleeding in pregnant women with artificial heart valves, and hence, close monitoring must be done.
Consult your doctor for more advice before starting Graviparin 300mg Injection medication, it is recommended not to take any hemostatic drugs unless absolutely necessary. It is needed to inform your physician about all the drugs you are taking, including herbal and vitamin supplements.
Uses of Graviparin 300mg Injection
Graviparin 300mg Injection is used in the treatment of the following:
- Deep vein thrombosis
- Prophylaxis of venous thrombo-embolism
- Unstable angina
- ST-segment Elevation Myocardial Infarction (STEMI)
- Prevention of blood clots during surgeries
Therapeutic Effects of Graviparin 300mg Injection
Graviparin 300mg Injection binds to the antithrombin to form a complex. Antithrombin is a protein that blocks the formation of abnormal blood clots. This drug mainly prevents the activation of factor Xa, eventually preventing clot formation. It is commonly used for the prevention and treatment of conditions associated with increased risk of blood clots.
Interaction of Graviparin 300mg Injection with other drugs
Some medicinal products that affect haemostasis should be discontinued before starting Graviparin 300mg Injection therapy unless absolutely necessary. If a combination is required, Graviparin 300mg Injection should be used with careful clinical and laboratory monitoring. These products include systemic salicylates, acetylsalicylic acid at anti-inflammatory doses, NSAIDs like ketorolac, other thrombolytics such as alteplase, reteplase, streptokinase, tenecteplase, urokinase, and other anticoagulants. Always inform your doctor about any medicines or supplements you are taking, as they may interact with Graviparin 300mg Injection.
More Information about Graviparin 300mg Injection
- Store Graviparin 300mg Injection below 25 °C.
- Do not freeze
- Keep it out of reach from children.
- Protect them from light and moisture.
How to consume Graviparin 300mg Injection
Graviparin 300mg Injection will be administered to you by a healthcare professional in a hospital setting. It is usually administered as an intravenous injection into a vein. Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors.
Safety Advice for Graviparin 300mg Injection
Breast Feeding
It is unknown if Graviparin 300mg Injection is excreted unaltered in breast milk. Please consult your doctor before breastfeeding.
Alcohol
It is unknown if consuming alcoholic beverages while taking Graviparin 300mg Injection is safe. Please consult with your physician.
Liver
Inform your doctor if you have liver disease because of Graviparin 300mg Injection should be used cautiously with a liver condition.
Lungs
It is unknown whether Graviparin 300mg Injection is safe for patients with lung problems. Consult your doctor if you have lung disease before starting the treatment.
Driving
It is safe to travel, drive a car, or operate heavy machinery after receiving Graviparin 300mg Injection. Graviparin 300mg Injection does not impair alertness or coordination.
Pregnancy
Before beginning therapy with Graviparin 300mg Injection, tell your doctor if you are pregnant, suspect you are pregnant, or are planning to become pregnant. It is not known that Graviparin 300mg Injection interferes with pregnancy.
Side Effects of Graviparin 300mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious side effects of Graviparin 300mg Injection are:
- Severe allergic reactions (swelling of lips, tongue, or throat, difficulty breathing, or swallowing)
- Too much bleeding (weakness, being pale, dizziness with headache, or unexplained swelling)
- Blockage of blood vessels (pain, redness, or swelling in the legs, or coughing up blood)
- Rash of dark red spots under the skin
Common side effects of Graviparin 300mg Injection are:
- Bleeding
- Bruising more easily
- Low blood cell counts
- Headache
- Itchy red skin
- Edema
- Pain at the injection site
- Pink patches on the skin
Word of Advice
Graviparin 300mg Injection can cause bleeding and many undesirable side effects; hence it is advised to get adequate rest during the treatment. Eat a well-balanced diet. Apply a cool compress at the injection site to reduce pain and irritation. Graviparin 300mg Injection should not be stopped suddenly without first talking to your doctor because doing so may raise your risk of blood clots.
Aspirin and other non-steroidal anti-inflammatory medicines (NSAIDs) may increase the risk of bleeding when combined with Graviparin 300mg Injection, so it is not recommended to take them without first talking to your doctor. Keep away from activities that put you at higher risk of bleeding or getting hurt, like contact sports and activities.
Foods high in Vitamin K may have an impact on blood clotting and may interfere with the way anticoagulant drugs like Graviparin 300mg Injection. It is recommended to eat leafy green vegetables, asparagus, Brussels sprouts and soybean oil in moderation. It is advised to monitor your platelet count regularly.
FAQs about Graviparin 300mg Injection
Q1.
Who should not take Graviparin 300mg Injection?
Graviparin 300mg Injection is not recommended for people suffering from active major bleeding or a history of hypersensitivity to Graviparin 300mg Injection, heparin, Benzyl alcohol, or pork products. This drug is also not advised for people with a history of heparin-induced thrombocytopenia in the past hundred days.
Q2.
What should I not take with Graviparin 300mg Injection?
When taking Graviparin 300mg Injection, it's important to avoid certain medications, supplements, and activities that may increase the risk of bleeding or interact with the anticoagulant effects of Graviparin 300mg Injection includes other anticoagulants, non-steroidal anti-inflammatory drugs, and anti-platelets.
Q3.
What are the common side effects of Graviparin 300mg Injection?
Common side effects of Graviparin 300mg Injection may include bleeding or bruising at the injection site, nosebleeds, nausea, headache, and itching. Serious side effects such as severe bleeding or allergic reactions are rare but may occur.
Q4.
How long should Graviparin 300mg Injection treatment continue?
The duration of Graviparin 300mg Injection treatment depends on the underlying condition being treated, the risk of clotting, and individual patient factors. Treatment may be short-term (e.g., during hospitalisation or surgical procedures) or long-term for chronic conditions such as DVT or PE.
Q5.
When should you report to the doctor while using Graviparin 300mg Injection?
Contact your physician directly if you experience severe allergic reactions like the spelling of lips, tongue, throat, difficulty breathing or swallowing, unexplained swelling, painful Rash, chest pain, or blood in the cough during the treatment with Graviparin 300mg Injection.
Q6.
How should Graviparin 300mg Injection be stored?
Graviparin 300mg Injection should be stored at room temperature (between 68°F to 77°F or 20°C to 25°C) away from light and moisture. It should be kept out of the reach of children and not be frozen. Unused portions of Graviparin 300mg Injection solution should be discarded according to the manufacturer's instructions.
Fact Box of Graviparin 300mg Injection
| Molecule Name: Enoxaparin | Therapeutic class: Anticoagulant |
| Pharmacological class: Low molecular weight heparin (LMWH) | Indications: Treat and prevent blood clot |
References
1. Rovi Pharma Industrial ServicesElectronic Medicines Compendium (EMC), [Revised on Apr 2022], [Accessed on March 2024],https://www.medicines.org.uk/emc/files/pil.9331.pdf
2. Sanofi, [Revised on Apr 2022] [Accessed on March 2024], https://products.sanofi.us/lovenox/lovenox.pdf
3. Sanofi India Limited, Central Drugs Standard Control Organisation (CDSCO), [Revised on Dec 2018], [Accessed on March 2024], https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadPrescribingInfo/1CLEXANE-SANOFI.pdf
4. KD Tripathi, Essentials of Medical Pharmacology, Drugs Affecting Coagulation, Bleeding and Thrombosis, 8th Edition, 2019, 659-681.
5. https://www.ema.europa.eu/en/documents/product-information/inhixa-epar-product-information_en.pdf
Disclaimer
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Author Details
Written By
Dr. Vijayalakshmi N.
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:29 AM (IST)
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