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Halsbev 400mg Injection
Prescription Required
Salt Composition : Bevacizumab
Manufacturer : HALSTED PHARMA PVT. LTD.
Origin of Medicine : India
1 Vial(s)
Introduction to Halsbev 400mg Injection
Halsbev 400mg Injection is a monoclonal antibody consisting of the active ingredient Bevacizumab. It is used to treat adults with advanced large intestine cancer (colon or rectum) along with chemotherapy medication. It is also used in treating metastatic breast cancer, advanced non-small cell lung cancer and kidney cancer, and also used in advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer. It is also used to treat persistent, recurrent cervical cancer in patients. Inform your doctor if you are allergic to Halsbev 400mg Injection or any of its ingredients. It is recommended to consult your doctor if you have an abdomen inflammation, cervical cancer, risk of bleeding or wound healing, or have an unhealed wound after the surgery. Consult your doctor if you have a skin infection, hypertension, aneurysm (enlarged or weakening blood vessels), or risk of blood clots in the arteries or veins, bleeding or bleeding-related problems, or heart problems. You may be recommended to have a dental checkup before starting to take the medicine. Inform your doctor or dentist immediately if you have pain in the mouth, teeth, or jaw, swelling inside the mouth, numbness in the jaw, or loosening of a tooth while using the medication.
The safety and efficacy of the medicine have not been established in children below 18 years of age. Consult your doctor if you are planning to get pregnant or think you may be pregnant or while you are breastfeeding. Patients who are older than 65 years may have an increased risk of stroke or heart attack, reduced blood count (WBC and platelets), diarrhea, sickness, headache, fatigue, or high blood pressure while under the medication.
Uses of Halsbev 400mg Injection
- Advanced stage of large intestine cancer
- Metastatic breast cancer
- Advanced non-small cell lung cancer
- Advanced kidney cancer
- Advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer
- Persistent, recurrent cervical cancer
Therapeutic Effects of Halsbev 400mg Injection
Halsbev 400mg Injection is a recombinant humanized monoclonal antibody that works as a targeted therapy in the treatment of various advanced cancers. It produces its action by selectively binding to the vascular endothelial growth factor A (VEGF-A) protein, which is present in the lining of blood and lymph vessels in the body. It interrupts the interaction of VEGF-A with its receptors. This further inhibits the formation of blood vessels that supply oxygen and nutrients to the tumor. As a result, it slows down the rate of progression of cancer.
Interaction of Halsbev 400mg Injection with other drugs
Inform your doctor about prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Halsbev 400mg Injection, reducing effectiveness by causing undesirable side effects.
More Information about Halsbev 400mg Injection
- Store at 2-8˚C
- Protect from light.
- Keep children away from the sight and reach of this medication.
How to consume Halsbev 400mg Injection
This medicine is given only in a hospital by a healthcare provider. Your doctor will provide you with Halsbev 400mg Injection intravenously (into a vein). Your physician will decide the dosage and frequency of this injection based on the severity of your disease and other factors.
Safety Advices for Halsbev 400mg Injection
Pregnancy
Limited information is available on the use of Halsbev 400mg Injection during pregnancy. Notify your healthcare professional if you are pregnant or planning to have a baby. If you think you may be pregnant.
Breast Feeding
Limited information is available on using Halsbev 400mg Injection during breastfeeding. So, before starting the treatment, inform your doctor if you are breastfeeding. Contact your doctor for more details.
Lungs
It is unknown whether Halsbev 400mg Injection is safe for patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
Liver
Individuals who have liver problems are recommended to discuss with their doctor in order to avoid the side effects caused by the drug.
Alcohol
Individuals are cautious while consuming alcohol if they are under Halsbev 400mg Injection medication. Consult your doctor before using the medicine.
Driving
It is unknown whether Halsbev 400mg Injection alters driving ability. However, if you experience side effects like tiredness or drowsiness, avoid driving and using machines.
Side Effects of Halsbev 400mg Injection
Side effects are unwanted symptoms caused by medicines. Although all drugs cause side effects, not everyone experiences them.
Serious:
- High blood pressure
- Feeling of numbness or tingling in hands or feet
- Decreased blood count
- Lack of energy and tiredness
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain.
- Gut problem (perforation)
- Bleeding or blood clotting disorder
- Heart failure
- Wound healing problem (surgery)
- Stomach or intestinal disorder
- Muscle problem
- Dry mouth, thirst, or reduced urine
- Inflammation of the linings in the mouth, gut, lung and air passage, reproductive and urinary tract)
- Sore mouth
- Pain (back, pelvis or anal regions)
- Pus
- Infection
- Sleepiness
- Nose bleeding
- Allergic reactions (the signs may include breathing difficulty, facial redness, rash, low blood pressure or high blood pressure, chest pain, or nausea/vomiting)
Common:
- Constipation
- Loss of appetite
- Fever
- Problems with the eyes (including increased production of tears),
- Changes in speech
- Change in the sense of taste
- Runny nose
- Dryness or inflammation of the skin
- Loss of body weight
- Nose bleeds
- Voice changes and hoarseness
Word of Advice
Drinking at least two liters of water and eating a healthy diet that contains fiber may help you recover from constipation. Sufficient amounts of water and electrolytes help compensate for the water loss caused by diarrhea and vomiting. Your doctor may recommend you to check your blood pressure level before taking the medicine. Avoid smoking, drinking alcohol, and eating foods that irritate your mouth.
FAQs
Q 1. Is Halsbev 400mg Injection used as a standalone treatment in cancers?
Halsbev 400mg Injection is a recombinant monoclonal antibody that belongs to the immunotherapy class of cancer treatment. It can either be used as monotherapy or in combination with chemotherapy or immunotherapy medications to improve the overall survival rate.
Q 2. Is it safe to undergo surgery during the treatment with Halsbev 400mg Injection?
Halsbev 400mg Injection is associated with an increased risk of bleeding complications and poor wound healing. Hence, it is suggested to avoid planning for surgery and maintain an interval of 28 days before or after surgery.
Q 3. Is it safe for elderly individuals to use Halsbev 400mg Injection?
It is recommended that if you are a patient who is older than 65 years, you may be at an increased risk of stroke or heart attack, reduced blood count (WBC and platelets), diarrhea, sickness, headache, fatigue, or high blood pressure while under the medication.
Q 4. Is the Halsbev 400mg Injection causing tooth or oral problems?
Yes, Halsbev 400mg Injection may cause tooth or oral problems. You may be recommended to have a dental checkup before starting taking the medicine. Inform your doctor or dentist immediately if you have pain in the mouth, teeth, jaw, swelling or sores inside the mouth, numbness in the jaw, or loosening of a tooth while using the medication.
Q 5. What is the mechanism of action for Halsbev 400mg Injection?
Halsbev 400mg Injection is a recombinant humanized monoclonal antibody that works as a targeted therapy in the treatment of various advanced cancers. It produces its action by selectively binding to the vascular endothelial growth factor A (VEGF-A) protein, which is present in the lining of blood and lymph vessels in the body. It interrupts the interaction of VEGF-A with its receptors. This further inhibits the formation of blood vessels that supply oxygen and nutrients to the tumor. As a result, it slows down the rate of progression of cancer.
Fact Box of Halsbev 400mg Injection
Molecule name: Bevacizumab | Therapeutic class: Monoclonal antibody |
Pharmacological class: VEGF Inhibitor | Indications: 1. Advanced stage of large intestine cancer 2. Metastatic breast cancer 3. Advanced non-small cell lung cancer 4. Advanced kidney cancer 5. Advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer 6. Persistent, recurrent or metastatic cervical cancer |
Dosage form: Injection | Habit forming : No |
References
- Roche Products Limited, Electronic Medicines Compendium (EMC), [Revised on Nov 2022] [Accessed on 02/04/2023], https://www.medicines.org.uk/emc/files/pil.3885.pdf
- G.G. Dark, A.R. Abdul Razak, Oncology, Davidson's Principles & Practice of Medicine, 22nd Edition, 2014, 259-282.
- KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
- Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
- Genentech, Inc., U.S FDA, [Revised on Sep 2022][ Accessed on 02/04/2024], https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/125085s340lbl.pdf
- Roche Group,Halsbev 100mg Injection Injection, Indication,[Revised on 2020] [Accessed on 21/11/2022]https://www.avastin.com/patient/mcrc.html
Disclaimer
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