Inflitza capsule uses: 

• Acute myeloid leukemia (AML)

• Aggressive systemic mastocytosis (ASM)

• Systemic mastocytosis with associated hematological neoplasm (SM-AHN)

• Mast cell leukemia (MCL)

Inflitza 25mg capsule is a kinase inhibitor that potently inhibits multiple receptor tyrosine kinases. It blocks the action of the kinases in the abnormal cells that express FLT3 mutant genes and stops their division and growth.

Inform your healthcare provider about all the medicines you are taking, including prescription medications, over-the-counter medications, vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of inflitza 25mg capsule and reduce its effectiveness by causing undesirable side effects.

• Store inflitza 25mg capsule at room temperature (25°C)
• keep the capsule away from the reach of children and pets.
• If you miss a dosage, take it as soon as you remember. If it is almost time for the next dose, skip the missing dose.
• Do not take a double dose to compensate for a missed dose.

Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Take the inflitza 25mg capsule as prescribed by your doctor. Do not open, break, crush, or chew the capsules. Swallow the capsule whole with a glass of water. Take the capsules with food at the same time each day.

Inflitza 25mg Capsule side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Inflitza 25mg side effects are

Serious 

• Heart failure

• GI bleeding

• Fever with decreased blood cell counts

• Hypersensitivity reactions

• Kidney problems

• Pneumonia

• Blood infection

Common:

• Swelling in the lower limbs

• Skin rash

• Increased blood sugar levels

• Abdominal pain

• Constipation, diarrhea

• Nausea, vomiting

• Musculoskeletal pain

• Headache

• Bleeding from nose

• Upper respiratory infection

• Tiredness

• Fever

• Avoid grapefruit, grapefruit juice, and products containing St. John's wort during treatment.

• Use effective birth control during treatment, for at least three weeks after the final dose for females, and fourteen weeks for males.

• This medication may reduce fertility, so consult your doctor if you have any concerns.

• Your doctor may recommend regular blood tests to monitor the effect of Piciclib 100 mg on your blood cells.

1. Rydapt 25 mg soft capsules - Summary of Product Characteristics (SmPC) - (EMC). www.medicines.org.uk. [revised on 2022] [cited 2023 Apr 13]. Available from: https://www.medicines.org.uk/emc/product/9134/smpc
2. Highlights Of Prescribing Information - Inflitza 25mg capsule, [revised on 2017] [cited 2023 Apr 13]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207997s000lbl.pdf
3. Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors, and Various Small Molecules, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1203-1236.