Lorbriqua 100mg tablet is a drug belonging to the class of tyrosine kinase inhibitors, containing the active ingredient Lorlatinib. It is used to treat metastatic non-small cell lung cancer (NSCLC). This is the most common type of lung cancer. Metastatic non-small cell lung cancer (NSCLC) is a type of lung cancer that has spread to other parts of the body, such as the bones, liver, brain, or other organs.

During the treatment, your doctor may periodically monitor your white blood cell counts, platelets, blood sugar, electrolytes, and kidney parameters to prevent serious complications. This medicine has the potential to cause liver damage. Also, it may cause decreased fertility in males and this could affect your ability to father a child. Talk to your healthcare provider if you have concerns about fertility.

Inform the doctor if you have been diagnosed with liver disorders, heart failure, high blood cholesterol levels, or hypertension before starting this treatment. Report to your doctor if you experience any hypersensitive reactions like itchy skin or rashes while taking this medicine. It is advised to avoid drinking grapefruit juice while taking this drug, as it may increase the level of the drug in the blood and cause side effects. This tablet contains lactose as an inactive ingredient in which the body is unable to digest lactose, a sugar found in milk and dairy products. It can cause symptoms such as bloating, and abdominal pain. If you have lactose intolerance, inform your doctor before starting this therapy.

• Metastatic non-small cell lung cancer (NSCLC)

It works by inhibiting the tyrosine kinases, thus preventing the activation of downstream signalling pathways that are involved in cell proliferation, survival, and differentiation. This leads to the inhibition of cancer cell growth and survival.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Lorbriqua 100mg tablet and reduce effectiveness by causing undesirable side effects.

• Store Lorbriqua 100mg tablet in the original package at a controlled room temperature (20°C to 25°C).
• Keep it out of reach from children.

Your doctor will decide the dose and duration of Lorbriqua 100mg tablet based on the disease condition and other factors. Take the tablet at the same time everyday, with or without food. Do not chew, crush, or break the tablet. Swallow the whole tablet with water. If you forgot to take the tablet, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious

• Cough, chest pain, or worsening of breathing problems
• Feeling tired, faint, or losing consciousness
• Yellowing of the skin and eyes, vomiting, abdominal pain
• Confusion, memory loss, mood swings, difficulty speaking, seeing, or hearing things that are not real

Common

• Increase in cholesterol levels
• Swelling in hand or legs
• Double vision difficulty seeing
• Pain, numbness, or unusual sensations (burning or pin and needles) in arms and legs, difficulty walking
• Diarrhoea, constipation
• Headache
• Weight gain
• Joint pain, muscle pain
• Rash
• Anaemia

Lorbriqua 100mg tablet is not recommended for pregnant women as it may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment. Discuss effective nonhormonal contraceptive methods with your healthcare provider and use them during this treatment and continue for at least six months after the last dose. It is not known if this drug passes into breast milk. Hence, it is not recommended to breastfeed during this treatment. This medicine may increase your blood sugar levels. Your healthcare provider should do blood tests to check your blood sugar levels before starting and during treatment with this drug. It is important to start or change your medicine to control your blood sugar levels. Report to your doctor right away if you get new or worsening signs and symptoms of high blood sugar such as feeling thirsty, confused, and tired. This tablet might cause breathing difficulty and problems with thinking. Hence it is advisable to avoid driving or operating machines during this treatment. Before starting this treatment, inform your doctor if you are taking any prescription medicines, over-the-counter medicines, vitamins, or herbal supplements.

1. Pfizer Ltd, [Revised on Mar 2021] [Accessed on 1st April 2023], https://labeling.pfizer.com/ShowLabeling.aspx?id=11140&Section=PPI
2. Pfizer Ltd, Electronic medicines compendium (emc), [Revised on March 2021] [Accessed on 1st April 2023], https://www.medicines.org.uk/emc/files/pil.10632.pdf
3. Pfizer, US Food and Drug Administration, [Revised on March 2021] [Accessed on 1st April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/210868s004lbl.pdf
4. Alice T Shaw et al; First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer; The New England Journal of Medicine; Published on 19/11/2020;[Accessed on 1st April 2023]; https://pubmed.ncbi.nlm.nih.gov/33207094/
5. Haidar El Darsa, Omar Abdel-Rahman & Randeep Sangha (2020) Pharmacological and clinical properties of lorlatinib in the treatment of ALK-rearranged advanced non-small cell lung cancer, Expert Opinion on Pharmacotherapy, 21:13, 1547-1554,[Accessed on 1st April 2023], https://doi.org/10.1080/14656566.2020.1774552
6. Gafer H, de Waard Q, Compter A, van den Heuvel M. Rapid regression of neurological symptoms in patients with metastasis ALK+ lung cancer who are treated with lorlatinib: a report of two cases. BMJ Case Rep. 2019 Jul 24;12(7):e227299,[Accessed on 1st April 2023], https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663151/pdf/bcr-2018-227299.pdf