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Lupride Depot 11.25mg Injection
Last updated on 31 Mar 2026 | 09:31 AM (IST)
₹7807
MRP: ₹9758.65
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Lupride Depot 11.25mg Injection contains leuprolide acetate, a gonadotropin-releasing hormone (GnRH) agonist used to treat prostate cancer, endometriosis, and uterine fibroids. It works by lowering hormone levels to control disease progression. The injection is administered intramuscularly under medical supervision.
Sourced from:Manufacturer Authorized Distributor
Lupride Depot 11.25mg Injection
Salt Composition
LEUPROLIDE ACETATEMarketer
SUN PHARMACEUTICAL INDUSTRIES LTD
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Introduction
Lupride Depot 11.25mg injection contains Leuprolide acetate, which explains the Lupride Depot 11.25mg composition. It belongs to a group of medicines known as Gonadotropin Releasing Hormone (GnRH) agonists. This medicine works by reducing the production of certain hormones in the body.
Doctors commonly prescribe Sun Pharma Lupride Depot 11.25mg for hormone-dependent conditions. Its approved uses include Lupride Depot 11.25mg for prostate cancer, hormone-responsive breast cancer, and Lupride Depot 11.25mg in endometriosis, where uterine-like tissue grows outside the uterus and causes pain. It is also used for uterine fibroids and Lupride Depot 11.25mg for precocious puberty in children who experience early hormonal development.
The Lupride Depot 11.25mg injection frequency is usually once every three months, but the exact schedule is decided by the doctor based on the condition being treated and the patient’s response. Long-term treatment may affect bones, so doctors closely monitor Lupride Depot 11.25mg and bone density, especially in women and older patients.
Uses
Lupride Depot 11.25mg Injection uses are:
- Prostate cancer
- Hormone-responsive breast cancer in perimenopausal (around menopause) women
- Endometriosis (a painful illness in which the tissue that normally lines the inside of the uterus grows outside of your uterus)
- Central precocious puberty (a child’s body begins to change into an adult too soon caused by a release of certain hormones)
How Lupride Depot 11.25mg Injection Works
Lupride Depot 11.25mg decreases testosterone or estrogen production, depending on the treated condition. This helps to slow the growth of cancer cells, reduce the size of uterine fibroids, and alleviate the symptoms of endometriosis and early onset of puberty.
Interaction of Lupride Depot 11.25mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription, over-the-counter, nutritional and vitamin supplements, vaccines, and herbal products. Certain medications such as Quinidine, Procainamide, Amiodarone, Sotalol, Pain killers, and Antibiotics may interact with the effects of Lupride Depot 11.25mg and reduce its effectiveness by causing undesirable side effects.
Storage Conditions
- Keep Lupride Depot 11.25mg out of sight and reach of children.
- Store in a cool, dry place, away from direct heat and light.
- Store below 25°C
- Do not refrigerate or freeze.
How to use Lupride Depot 11.25mg Injection
Lupride Depot 11.25mg injection is usually administered in the arm, thigh or abdomen. If this injection is recommended for you, it will be given by a healthcare professional. Do not self-administer. Your physician will choose the Lupride Depot 11.25mg dosage and administration frequency based on the medical condition because it differs for each person.
Safety Advice for Lupride Depot 11.25mg Injection
Breast Feeding
Lupride Depot 11.25mg injection is contraindicated in breastfeeding women. Inform your doctor if you are breastfeeding before taking this injection.
Alcohol
Consuming alcohol during the Lupride Depot 11.25mg injection treatment may increase the risk of thinning bones (osteoporosis). Hence caution should be taken. Consult your doctor for more information
Liver
Lupride Depot 11.25mg should be used cautiously in patients with liver impairment. Consult your doctor before receiving it. Notify your doctor about underlying liver conditions.
Lungs
It is unknown whether Lupride Depot 11.25mg is safe for patients with lung problems. Notify your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
Driving
Lupride Depot 11.25mg injection can cause drowsiness, visual disturbances, or dizziness. It is unsafe; hence avoid driving if you are unwell.
Pregnancy
It is unsafe to use Lupride Depot 11.25mg injection because it is contraindicated in pregnant women. Tell your doctor if you are pregnant or planning to get pregnant before taking this treatment.
Side Effects
side effects of Lupride Depot 11.25mg are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious
- Severe rash, itching
- Shortness or difficulty of breath
- Cough with blood
- Pulmonary embolism
- Severe headache
Common
- Altered blood sugar and cholesterol levels
- Injection site reactions
- Loss of appetite
- Abnormal liver function
- Swelling in the ankle or hand
- Difficulty sleeping, headache
- Mood swings, depression
- Weight changes
- Nausea, vomiting
- Vaginal dryness, bleeding
- Loss of interest in sexual intercourse
- Hot flushes
- Bone pain, muscle weakness
- Breast tenderness
Expert tips
-
Regular checkups every three months are recommended during Lupride Depot 11.25mg treatment, especially when used with an aromatase inhibitor.
-
Do not take this injection if you experience abnormal vaginal bleeding and report persistent headaches, vision issues, or ringing in the ears to your doctor.
-
Diabetic patients should have regular blood sugar monitoring, and women should inform their doctor if they are still menstruating before starting treatment.
FAQs about Lupride Depot 11.25mg Injection
Q1.
What is the mechanism of action of Lupride Depot 11.25mg?
Lupride Depot 11.25mg decreases testosterone or estrogen production, depending on the treated condition. This helps to slow the growth of cancer cells, reduce the size of uterine fibroids, and alleviate the symptoms of endometriosis and early onset of puberty.
Q2.
Who should not use Lupride Depot 11.25mg?
Lupride Depot 11.25mg should not be used by pregnant and breastfeeding women, people who are allergic to the medication, or people with a history of osteoporosis or bone fractures. It should also be used cautiously in people with a past of depression or mental illness.
Q3.
What should I do if I miss a dose of Lupride Depot 11.25mg?
If you miss a dose of Lupride Depot 11.25mg, contact your healthcare provider as soon as possible to schedule the missed dose. Do not double up on doses to make up for a missed one.
Q4.
Can Lupride Depot 11.25mg cause weight gain?
Weight gain is not a common side effect of Lupride Depot 11.25mg, but it may occur in some people.
Q5.
What effect does Lupride Depot 11.25mg have on people with endometriosis?
Lupride Depot 11.25mg reduces estrogen production and helps relieve endometriosis symptoms by inhibiting tissue growth outside the uterus.
Fact Box
|
Molecule name: |
Leuprolide acetate |
|
Therapeutic class: |
Antineoplastics |
|
Pharmacological class: |
Gonadotropin-Releasing Hormone (GnRH) agonists |
|
Indication: |
1. Prostate cancer 2.Hormone-responsive breast cancer in perimenopausal (around menopause) women 3. Endometriosis (a painful illness in which the tissue that normally lines the inside of the uterus grows outside of your uterus) 4. Central precocious puberty (a child’s body begins to change into an adult too soon caused by a release of certain hormones) |
References
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Introduction to Endocrinology: The hypothalamic-pituitary axis, 12th edition, 2011, 1122.
- KD Tripathi, Essentials of Medical Pharmacology, Anterior pituitary hormones, 7th edition, 2013, 243.
- Takeda UK Limited, Electronic medicines compendium (emc), [ Revised on June 2022] [ Accessed on 12th April 2023], https://www.medicines.org.uk/emc/product/4651/smpc
- Abbott Laboratories, US Food and Drug Administration, [Issued on Feb 2016] [ Accessed on 12th April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020517s036_019732s041lbl.pdf
Disclaimer
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Author Details

Written By
Aswini Priya Velmurugan
PG in Biotechnology

Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:31 AM (IST)

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