Megpro 160mg tablet uses are:

• Treatment of hormone-dependent breast cancer in advanced or recurrent stages.
• Management of endometrial cancer in certain cases.
• Treatment of cachexia (muscle wasting), anorexia (loss of appetite), and unexplained weight loss in patients with acquired immunodeficiency syndrome (AIDS) or cancer.
• Supportive therapy to improve nutritional status and enhance quality of life in individuals with chronic debilitating conditions.

Megpro 160mg Tablet works by mimicking the actions of natural progesterone, a hormone involved in regulating the growth of certain tissues. It slows the progression of hormone-sensitive cancers, such as breast and endometrial cancer, by inhibiting the effects of estrogen. This action prevents the cancer cells from multiplying and spreading.

In cases of cachexia and anorexia, it enhances appetite and promotes weight gain by affecting the hypothalamus (the part of the brain that controls hunger). Additionally, it alters the metabolism of proteins and fats, which helps restore body mass in patients experiencing severe weight loss due to chronic illness. By addressing both hormonal and metabolic imbalances, this medication plays a critical role in improving patients' overall condition.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications interact with Megpro 160mg Tablet and reduce its effectiveness by causing undesirable side effects.

• Store below 25°C.
• Protect from light and moisture.
• Keep away from children and pets.

Megpro 160mg Tablet is taken orally and should be used exactly as prescribed by your doctor. The typical dosage for treating breast or endometrial cancer is 160 mg per day, which may be administered as a single dose or divided into smaller doses based on medical advice. It can be taken with or without food, but taking it at the same time each day ensures consistent absorption. The tablet should be swallowed whole with water, without crushing or breaking it. If a dose is missed, it should be taken as soon as possible unless it is close to the next scheduled dose. Dosage adjustments may be required depending on the patient’s response and medical condition.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Swelling of the face, lips, tongue
• Skin rash
• Breathing difficulty
• Blood clot in the lungs
• Heart problems

Common:

• Weight gain and increased appetite
• Hot flushes
• High BP
• High blood sugar levels
• Rounded face
• Constipation
• Swelling of vein
• Mood changes
• Hair loss
• Diarrhea
• Tiredness and weakness
• Impotence
• Passing wind
• Frequent urination
• Nausea, vomiting
• Fluid accumulation
• Pain

Inform the doctor if the patient has any history of kidney, liver, allergic reactions before starting this medication. Kidneys,liver, blood pressure and blood glucose levels should be monitored while taking this medication and avoid taking this medication while planning for pregnancy or during pregnancy as it causes harmful effects on developing babies. This medication should not be stopped without proper advice from the doctor because it can worsen the situation. Inform the doctor immediately if there are any signs of swelling and pain in the limbs, shortness of breath, chest pain, severe headache, or changes in vision.

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2. alniche Life Sciences Pvt Ltd., [Revised on 2021] [Accessed on 19th Jul 2021], https://www.alniche.com/product/megahenz/
3. Bines et al., Activity of megestrol acetate in postmenopausal women with advanced breast cancer after nonsteroidal aromatase inhibitor failure: a phase II trial, Annals of Oncology, 2014, 25(4), 831-836, https://www.annalsofoncology.org/action/showPdf?pii=S0923-7534%2819%2936501-9
4. G.G. Dark, A.R. Abdul Razak, Oncology, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 259-282.