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Ontramab 440mg Injection
Salt Composition : Trastuzumab
Manufacturer : CELON LABORATORIES LTD
Origin of Medicine : India
Introduction to Ontramab 440mg Injection
Ontramab 440mg Injection consists of Trastuzumab as an active constituent which is indicated for its use in HER 2 breast cancer. In HER 2 positive patients, the breast cancer cells are mostly composed of HER2 proteins that cause rapid development of cancer tumor by serving as a signal to the cancerous. This medication is also used to treat metastatic gastric cancer with increased levels of HER2 proteins.
Her 2 positive breast cancer are most aggressive in nature. The targeted therapy for her 2 positive breast cancer works by selectively targeting the proteins that are responsible for the growth, development, and spread of cancer. Use effective birth control during the treatment and for at least 7 months after the final dose.
Ontramab 440mg Injection is not recommended for patients aged under 18, patients who have severe breathing problems or need oxygen treatment. It is necessary to let your physician know if you have any heart problems, breathlessness, or have ever had any other cancer treatment. Make sure you inform your physician of all the medicines, including supplements and herbal medicines, you are taking before you start treatment with this medication.
Uses of Ontramab 440mg Injection
Ontramab 440mg Injection is indicated for its use in the following conditions:
- Advanced and metastatic breast cancer
- Metastatic gastric cancer
Therapeutic Effects of Ontramab 440mg Injection
The protein called HER2 (human epidermal growth factor receptor 2) is found in abundant amounts on the surface of certain cancer cells, where it stimulates cancer growth. Ontramab 440mg Injection selectively binds to HER2 and stops the growth of cancer cells.
Interaction of Ontramab 440mg Injection with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Ontramab 440mg Injection and cause undesirable side effects.
More Information about Ontramab 440mg Injection
- Keep Ontramab 440mg Injection out of sight and reach of children.
- Store between 2˚C and 8˚C.
How to consume Ontramab 440mg Injection
- Ontramab 440mg Injection shall either be administered before or after surgery.
- It will be given as an Intravenous infusion for 90 minutes, if well tolerated it shall be administered within 30 minutes for the next doses.
Safety Advices for Ontramab 440mg Injection
Discuss with your physician before taking this Ontramab 440mg Injection if you are pregnant or think you might be pregnant. Do not take this medicine during the pregnancy unless advised by the doctor to take as it may cause to the unborn baby.
Avoid breastfeeding your baby while on the treatment with Ontramab 440mg Injection atleast for at least seven months after the final dose.
Talk to your doctor if you have any lung conditions before starting treatment with Ontramab 440mg Injection.
You need to tell your physician if you have any liver disorders before starting Ontramab 440mg Injection as it requires dosage adjustment for severe liver impairment.
Consult your doctor to know if it is safe to consume alcohol while you are on treatment with Ontramab 440mg Injection.
Ontramab 440mg Injection can cause unusual tiredness and dizziness. Hence, it is advised to avoid driving or handling machinery during the treatment.
Side Effects of Ontramab 440mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
- Heart Problems
- Allergic reactions
- Kidney problems
- Breathing difficulties
- Visual disturbances
- Nose bleeds or runny nose
- Hair loss
- Nail disorders
- Weight loss
- Loss of appetite
- Dry mouth
- Liver inflammation
- Muscle pain
- Asthma/ lung disorders
Word of Advice
It is suggested to inform your doctor if you have a history of allergic reactions to Ontramab 440mg Injection to avoid life-threatening complications. If you have a history of lung disorder or breathing problems inform your doctor beforehand before the treatment commencement. Avoid planning for pregnancy and breastfeeding for a minimum of 7 months after the last dose. Monitor your heart parameters regularly during the treatment with Ontramab 440mg Injection as it may impact the functioning of heart.
Q 1. Is Ontramab 440mg Injection used as a monotherapy in treating breast cancer?
Ontramab 440mg Injection is generally given along with the chemotherapy medication such as paclitaxel or docetaxel or platinum compunds. Sometimes, it is also given with hormonal agents for those patients with elevated hormonal status.
Q 2. Does Ontramab 440mg Injection cause heart problems?
Yes, Ontramab 440mg Injection can damage the heart muscles. Hence to prevent the worsening of symptoms, it is advised to do heart check up every 3 months and continue till 2-5 years after the treatment completion.
Q 3. Can I breastfeed while on treatment with Ontramab 440mg Injection?
No, since tends to pass into breast milk, it is unsafe to breastfeed. Hence, It is advised not to breastfeed for a minimum of 7 months after the treatment with Ontramab 440mg Injection.
Q 4. Can Ontramab 440mg Injection be consumed during pregnancy?
No, it is unsafe to consume Ontramab 440mg Injection while you are pregnant or this medicine can cause harm to the baby by reducing the amount of amniotic fluid,the fluid surrounding the womb. It can also cause organ developmental issues such as poor lung development when consumed during pregnancy. If you are planning for pregnancy, it is advised to discuss the birth control methods as this medicine may impair your fertility.
Fact Box of Ontramab 440mg Injection
Molecule name: Trastuzumab
|Therapeutic class: Anti-cancer|
Pharmacological class: HER2 inhibitor
1. Advanced and metastatic breast cancer
2. Metastatic gastric cancer
1. Roche, Electronic Medicines Compendium (EMC), [Revised on Jan 2022] [Accessed on 12th July 2022], https://www.medicines.org.uk/emc/files/pil.3856.pdf
2. Genentech Inc, [Revised on Feb 2021] [Accessed on 12th July 2022], https://www.gene.com/download/pdf/herceptin_prescribing.pdf
3. Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors, and Various Small Molecules, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1203-1236.
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