Quick Summary
Opsutan Tablet
Last updated on 13 Apr 2026 | 06:20 AM (IST)
₹1949
MRP: ₹2292.84
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10 TABLET(s) IN A STRIP
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₹1949
MRP: ₹2,292.84
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Substitutes
Macikad 10mg Tablet
LUPIN LTD
₹ 194.60/tablet
0% cheaper
Macitent 10mg Tablet
MSN LABORATORIE...
₹ 203.40/tablet
5% costlier
Introduction
Opsutan Tablet contains the active ingredient macitentan and belongs to the class of endothelin receptor antagonists, referred to as Opsutan Tablet composition. It is widely prescribed for the long-term treatment of pulmonary arterial hypertension (PAH) in adults, reflecting Opsutan 10mg uses, and can be taken alone or alongside other PAH therapies. Patients must follow the prescribed dosage strictly as advised by their healthcare professional. The medicine works through the Opsutan 10mg mechanism of action, helping to relax blood vessels and improve blood circulation.
Before starting treatment, patients should consult their doctor if they have any known allergies to the medicine, liver or lung conditions, are planning pregnancy, are pregnant, breastfeeding, or have concerns about male fertility. The safety and effectiveness of Opsutan Tablet in children remain unestablished.
Patients can explore alternatives listed under Opsutan 10mg substitutes, including options such as Cipla Opsutan 10 mg, commonly searched as Opsutan 10mg Cipla price. Many individuals also check the Opsutan 10mg price and Opsutan 10mg tablet 10s price, along with options to buy Opsutan 10 mg online for ease of access. Additionally, comparing Opsutan 10mg vs Opsumit and reviewing Opsutan 10mg tablet side effects helps patients make informed treatment decisions.
Uses
Opsutan 10 mg uses are
- Treatment of pulmonary arterial hypertension (PAH)
Therapeutic Effects of Opsutan Tablet
Opsutan tablet widens the arteries of the lung and makes the arteries pump the blood by the heart, which passes through it. It lowers the blood pressure, relieves the symptoms, and involves the improvising of pulmonary arterial hypertension (PAH).
Interaction of Opsutan Tablet with other drugs
Opsutan Tablet Drug Interactions
Opsutan Tablet (Macitentan) may interact with strong CYP3A4 inhibitors such as Ketoconazole, Itraconazole, and Ritonavir, leading to increased drug levels and a higher risk of side effects.
Opsutan Tablet should be used cautiously with strong CYP3A4 inducers like Rifampicin, Carbamazepine, and Phenytoin, as they may reduce its effectiveness.
Co-administration of Opsutan Tablet with Cyclosporine may increase macitentan exposure; careful monitoring is recommended.
Opsutan Tablet is not recommended for use with other endothelin receptor antagonists such as Bosentan or Ambrisentan due to an increased risk of adverse effects.
Opsutan Tablet may reduce the effectiveness of hormonal contraceptives; additional non-hormonal contraceptive methods should be considered.
Caution is advised when Opsutan Tablet is used alongside anticoagulants like Warfarin or other blood pressure-lowering medications due to potential additive effects.
Alcohol consumption while taking Opsutan Tablet may increase the risk of liver-related side effects and dizziness.
Storage conditions
- Protect from moisture
- Store opsutan tablet at 25˚C
- Keep children away from the sight and reach of this medication.
How to take Opsutan Tablet
Take opsutan tablet tablets as your physician advises. Swallow the tablets whole and intact. This tablets should be taken with food. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the medicine if your doctor advises you to stop.
Safety Advice for Opsutan Tablet
Breast Feeding
It is unknown whether opsutan tablet is excreted in breast milk, and it is not recommended for breastfeeding. Consult your doctor for more information.
Alcohol
It is unknown whether it is safe to consume alcohol under opsutan tablet medication. So, it is recommended to consult your doctor before taking medicine.
Liver
Inform your physician about any underlying liver disorders before taking opsutan tablet, as this medication should be used cautiously in liver disease patients.
Lungs
Inform your physician about any underlying lung disorders before taking opsutan tablet, as this medication should be used cautiously in lung disease patients.
Driving
Opsutan Tablet may cause headaches, tiredness, or drowsiness, which alters your driving ability. So, it is advised to consult your doctor before handling heavy machines or vehicles.
Pregnancy
Opsutan Tablet is not recommended for pregnant women as it may cause harm to the fetus. Notify your healthcare professional if you are pregnant or planning to have a baby think you may be pregnant.
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. Opsutan Tablet side effects are
Common
- Anaemia
- Headache
- Bronchitis (inflammation of the airways)
- Nasopharyngitis (throat and nasal passages inflammation)
- Oedema (swelling of the ankles and feet)
- Pharyngitis (inflammation of the throat)
- Urinary tract infection (bladder infection)
- Hypotension (low blood pressure)
- Nasal congestion (blocked nose)
- Flushing (redness of the skin)
Expert Tips
-
Your doctor may monitor liver function and blood levels, as this medicine can reduce red blood cells and alter liver enzymes.
-
Individuals with lactose intolerance or soy allergy should inform their doctor before taking Opsutan Tablet.
-
Kidney patients should use caution and consult their doctor, as the medicine may lower blood pressure and hemoglobin levels.
-
Inform your doctor if you are allergic to black pepper (piperine) before starting this medication.
Q1.
What are the precautions I need to take while taking opsutan tablet?
Inform your medical history to the doctor. It will be useful for him to treat you based on your health. Inform your doctor if you have kidney, liver, or lung disease before starting using opsutan tablet.
Q2.
What are things I should be cautious about, opsutan tablet?
Individuals who have lactose intolerance or are allergic to soy should inform their doctor before taking opsutan tablet.
Q3.
What happens if a pregnant woman takes opsutan tablet?
It is not recommended for pregnant women, as opsutan tablet may cause undesirable effects if used during the period of pregnancy.
Q4.
Is there a specific monitoring schedule or tests I must undergo while taking opsutan tablet?
You may be advised to monitor your liver function and blood level, opsutan tablet may reduce red blood cells and alter the liver enzyme.
Q5.
Can I drive while taking a opsutan tablet?
Opsutan tablets may cause headaches, tiredness, or drowsiness, which alters your driving ability. So, it is advised to consult your doctor before handling heavy machines or vehicles.
Q6.
Is Opsutan 10mg safe to use during pregnancy?
No, Opsutan 10mg is not safe during pregnancy as it may harm the unborn baby. Consult your doctor for alternatives.
Fact Box of Opsutan Tablet
|
Molecule name |
Macitentan |
|
Therapeutic class |
Anti-hypertensive |
|
Pharmacological class |
Endothelin receptor antagonists |
|
Indications |
Treatment of pulmonary arterial hypertension (PAH) |
References
- Janssen Pharmaceutica NV., Electronics Medicines Compendium (EMC), [Revised on Jan 2023], [Accessed on 18 Oct 2023], https://www.medicines.org.uk/emc/files/pil.5223.pdf
- Actelion Pharmaceuticals US, Inc., Food and Drug administration, [Revised on Oct 2018], [Accessed on Oct 18 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/204410s017lbl.pdf
- KD Tripathi, Essentials of Medical Pharmacology, Nitric oxide and vasoactive peptide signal molecules, 8th edition, 2019, 546-547.
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Author Details
Written By
Dr. Archana Gupta
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 13 Apr 2026 | 06:20 AM (IST)
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