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Orcefo SB 3gm Injection
Last updated on 31 Mar 2026 | 09:29 AM (IST)
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Introduction
Orcefo SB 3gm Injection contains two active ingredients in one injection. One of the active substances is Cefoperazone, which belongs to the group of medications called third-generation cephalosporin antibiotics. The other active substance is Sulbactam, which belongs to the group of medications called beta-lactamase inhibitors.
This combination is effective against a wide range of bacteria, and this drug is commonly used to treat serious infections such as urinary tract infections, respiratory tract infections, intra-abdominal infections, septicemia, meningitis, skin infections, bone infections, and endometritis.
Orcefo SB 3gm Injection is contraindicated in individuals with known hypersensitivity or allergy to it or its components. Report to your physician if you are allergic to any antibiotic group. Consumption of alcohol (including alcoholic beverages, medications containing alcohol, mouthwashes, or food preparations) during and up to the fifth day after Orcefo SB 3gm Injection administration can result in a disulfiram-like reaction. This reaction can cause flushing, sweating, headache, and an increased heart rate. It is important to avoid alcohol during this period.
Notify your doctor if you have severe or bloody stools while taking Orcefo SB 3gm Injection. Before taking this medicine, talk to your doctor if you have liver disorders, bowel diseases, or clotting disorders. This drug should be taken only if it is necessary during pregnancy.
As this medicine passes poorly into the breast milk of nursing mothers, caution should be exercised during breastfeeding. It is essential to consult with your physician for more advice
Uses of Orcefo SB 3gm Injection
Orcefo SB 3gm Injection is used in the treatment of the following:
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Respiratory Tract Infections
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Urinary Tract Infections
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Intra-abdominal Infections
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Septicemia
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Meningitis
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Skin and Soft Tissue Infections
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Bone and Joint Infections
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Endometritis
How Orcefo SB 3gm Injection Works
Orcefo SB 3gm Injection is an antibiotic that works by interfering with bacterial cell wall synthesis, leading to the destruction of the bacteria. Sulbactam, the beta-lactamase inhibitor, helps inactivate the beta-lactamase enzymes produced by certain bacteria. These enzymes prevent the breakdown of cefoperazone, enhancing its effectiveness against resistant bacteria.
Interaction of Orcefo SB 3gm Injection with other drugs
Inform your physician about all your medicines, including prescription, over-the-counter, vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of Orcefo SB 3gm Injection and reduce its effectiveness by causing undesirable side effects.
Storage Conditions
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Store Orcefo SB 3gm Injection at temperatures not exceeding 25°C
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Keep the Injection away from the reach of children and pets.
How to consume Orcefo SB 3gm Injection
Do not self-administer the Orcefo SB 3gm Injection. Your doctor will decide the duration and dose of your treatment based on the disease severity and other factors. It will be given as an intravenous infusion or intramuscular Injection, and you will be monitored carefully for unwanted side effects.
Safety Advices
Pregnancy
Orcefo SB 3gm Injection should be taken if necessary during pregnancy. Report to your doctor if you are pregnant, suspecting, or planning for the pregnancy before starting the treatment.
Breast Feeding
Breastfeeding is not recommended in patients taking Orcefo SB 3gm Injection because the medicine passes into the breast milk in small amounts and harms the baby. Caution is advised in these conditions.
Lungs
It is unknown whether Orcefo SB 3gm Injection is safe for patients with liver problems. Notify your physician if you have any liver disease before starting the treatment. Contact your doctor if you experience any liver-related symptoms.
Liver
It is unknown whether Orcefo SB 3gm Injection is safe for patients with liver problems. Notify your physician if you have any liver disease before starting the treatment. Contact your doctor if you experience any liver-related symptoms.
Alcohol
Patients taking Orcefo SB 3gm Injection should be cautioned about consuming alcoholic beverages during treatment and for several days afterwards. Consult your doctor for more advice.
Driving
Driving vehicles or operating heavy machinery is safe after administering Orcefo SB 3gm Injection.
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common side effects of Orcefo SB 3gm Injection are:
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Nausea, vomiting
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Headache
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Diarrhea
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Allergic reactions
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Anemia
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Abnormal liver function
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Injection site reactions
Expert Tips
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Wash your hands regularly to maintain good hygiene and help prevent the spread of infection to others.
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Do not skip doses or stop the medication early, even if you begin to feel better.
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Complete the full course of treatment as prescribed to fully treat the infection and reduce the risk of developing antibiotic resistance.
FAQs
Q1.
What is Orcefo SB 3gm Injection used for?
Orcefo SB 3gm Injection treats various bacterial infections, especially those caused by multidrug-resistant bacteria. It is commonly used for respiratory tract infections, urinary tract infections, skin infections, intra-abdominal infections, and gynaecological infections.
Q2.
Can Orcefo SB 3gm Injection be used during pregnancy or breastfeeding?
Orcefo SB 3gm Injection should be used during pregnancy or breastfeeding only if needed and prescribed by a healthcare professional. It's essential to discuss the risks and benefits with your doctor before using this medication in such situations.
Q3.
What are the common side effects of Orcefo SB 3gm Injection?
Common side effects of Orcefo SB 3gm Injection may include diarrhoea, nausea, vomiting, stomach pain, headache, dizziness, rash, itching, and local reactions at the injection site. Inform your healthcare provider if any side effects become severe.
Q4.
What is the Route of administering Orcefo SB 3gm Injection?
Orcefo SB 3gm Injection is given either as an intramuscular injection or through an intravenous infusion. The dosage and length of treatment depend on the type and severity of the infection, along with the patient's age and body weight. It should be used exactly as directed by the physician.
Q5.
What is the working mechanism of Orcefo SB 3gm Injection?
Orcefo SB 3gm Injection contains two active ingredients: Cefoperazone and Sulbactam. Cefoperazone is an antibiotic that disrupts the formation of bacterial cell walls, leading to the death of the bacteria. Sulbactam is a beta-lactamase inhibitor that blocks the enzymes produced by some bacteria which would otherwise make them resistant. This combination increases the overall effectiveness of the treatment.
Fact Box
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Molecule name: Cefoperaxone, Sulbactum |
Therapeutic class: Antibiotics |
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Pharmacological class: Cefoperazone - Third-generation cephalosporin Sulbactam - Beta-lactamase inhibitor |
Indications: 1. Respiratory Tract Infections 2. Urinary Tract Infections 3. Intra-abdominal Infections 4. Septicemia 5. Meningitis 6. Skin and Soft Tissue Infections 7. Bone and Joint Infections 8. Endometritis |
References
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Pfizer Limited, [Revised on April 2020] [ Accessed on 27th June 2021], https://labeling.pfizer.com/ShowLabeling.aspx?id=14800
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Pfizer, US Food and Drug Administration, [Revised on March 2015] [ Accessed on 27th June 2021],https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/050551s043lbl.pdf
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Goodman & Gilman's, The Pharmacological Basis of Therapeutics, Penicillins, cephalosporins, and other beta-lactam antibiotics, 12th edition, 2011, 1499.
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KD Tripathi, Essentials of Medical Pharmacology, Beta-lactam antibiotics, 7th edition, 2013, 728.
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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Author Details

Written By
P. Thirumal Reddy
B. Pharm

Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:29 AM (IST)

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