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Orplanin 400mg Injection
Last updated on 31 Mar 2026 | 09:29 AM (IST)
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Introduction
Orplanin 400mg Injection contains the active substance Teicoplanin. It is an antibiotic that belongs to the class of medications called glycopeptide. It is used in adults and children to treat bacterial infections of soft tissues, lungs, the urinary tract, endocarditis, the abdominal wall, blood, bones, and joints. It works by killing the bacteria that cause infections in the body.
Do not use Orplanin 400mg Injection if you are allergic to Teicoplanin or any of the other ingredients of this medicine. Inform your physician if you have flushing of the upper part of your body, a decrease in platelet count, kidney problems, and liver problems. Notify your doctor if you have allergic to an antibiotic called vancomycin. This medicine can cause serious rash or other skin symptoms.
Inform your physician if you are pregnant or breastfeeding before initiating the treatment. The side effects of Orplanin 400mg Injection are rash, pain, fever, decrease in platelet count, vomiting, diarrhea, dizziness, or headache. Inform your physician immediately if you experience sudden life-threatening allergic reactions such as difficulty breathing or wheezing, swelling, rash, itching, fever, and chills.
Uses of Orplanin 400mg Injection
The uses of Orplanin 400mg Injection include:
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To treat bacterial infections
How it works
Orplanin 400mg Injection works by killing the bacteria which can cause serious infections.
Interaction of Orplanin 400mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications interact with Orplanin 400mg Injection and reduce their effectiveness by causing undesirable side effects.
Storage conditions
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Store the Orplanin 400mg Injection below 30°C
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Do not freeze
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Protect the medicine from light and excessive moisture.
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Keep the medicine out of reach of children and pets
How to use Orplanin 400mg Injection
Orplanin 400mg Injection will be given to you by a doctor or other healthcare professional. It will be given as an intravenous injection (into a vein) or intramuscular (into a muscle). It can also be given as an infusion through a drip into a vein. Your healthcare provider will decide the dose, route of administration, and duration of the treatment based on your health condition and other factors. Do not self-administer the medicine.
Safety Advices
Pregnancy
Orplanin 400mg Injection may be unsafe to use during pregnancy. Your doctor will decide whether to use this medicine or not. Inform your physician if you are pregnant, suspecting pregnancy, or planning to get pregnant during the treatment.
Breast Feeding
Limited information is available on the use of Orplanin 400mg Injection during breastfeeding. Inform your physician if you are breastfeeding.
Lungs
It is unknown whether Orplanin 400mg Injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Liver
Orplanin 400mg Injection should be administered cautiously in patients with liver failure. Dose adjustments are necessary if you have liver problems. Inform your physician if you have any liver disease before initiating the therapy.
Alcohol
Consuming alcohol while taking Orplanin 400mg Injection does not cause any interactions and harmful side effects.
Driving
Orplanin 400mg Injection may cause headaches and dizziness. Do not drive or operate heavy machinery if you experience any side effects.
Side Effects of Orplanin 400mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common side effects of Orplanin 400mg Injection are:
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Skin rash
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Fever
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Pain
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Dizziness
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Diarrhea
Serious side effects of Orplanin 400mg Injection are:
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Severe allergic reactions
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Renal failure
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Decreased platelet counts
Expert Tips
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Inform your physician if you have any unusual bleeding.
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Monitoring with regular kidney function tests may be needed while you are being treated with this medication.
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Inform your physician if you are pregnant or breastfeeding before starting the treatment.
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Store this medicine as per the package information.
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Do not stop taking this medicine without talking to your doctor.
FAQs
Q1.
Does Orplanin 400mg Injection cross the blood-brain barrier?
Orplanin 400mg Injection shows a lower penetration rate into the blood-brain barrier than other glycopeptide antibiotics.
Q2.
Can Orplanin 400mg Injection be used in pediatric patients?
Orplanin 400mg Injection can be used in pediatric patients, but the dosage and administration will be determined based on the child's weight, age, and specific indication.
Q3.
Are there any specific side effects associated with Orplanin 400mg Injection?
Common side effects of Orplanin 400mg Injection may include gastrointestinal disturbances (such as nausea, vomiting, and diarrhoea), rash, dizziness, and decreased platelet counts. It is important to report any unusual or persistent side effects to your healthcare provider.
Fact Box
|
Molecule Name: Teicoplanin |
Therapeutic Class: Antibiotics |
|
Pharmacological Class: Semisynthetic Glycopeptide |
Indications: To treat bacterial infections |
References
1. Targocid 400mg powder for solution for injection/infusion or oral solution - Patient Information Leaflet (PIL) - (emc). www.medicines.org.uk. [revised 2022] [cited 2023 Jun 3]. Available from: https://www.medicines.org.uk/emc/product/2927/pil
2. Camille E. Beauduy, Lisa G. Winston, Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 795-814.
3. KD Tripathi, Macrolide, Lincosamide, Glycopeptide and other Antibacterial Antibiotics, Essentials of Medical Pharmacology, 8th Edition, 2019, 801-814.
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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Author Details

Written By
Sakshi Anil More
B. Pharm

Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:29 AM (IST)

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