Paleno 125 mg Capsule is a targeted therapy containing the active constituent palbociclib. This paleno palbociclib capsule belongs to the group of anticancer medications known as cyclin-dependent kinase inhibitors. Paleno breast cancer use on hormone receptor-positive, human epidermal growth factor 2 negative advanced or metastatic (has spread to other parts of the body) breast cancer. Cancer is a condition in which cells multiply in an uncontrolled and abnormal manner. It is given in combination with certain other anticancer medications.

The Paleno 125mg side effects that are likely to be associated with Paleno 125mg Capsule are nausea, vomiting, diarrhoea, tiredness, hair loss, dry skin, rash, infections, nose bleed, decreased appetite, low blood cell counts, swelling of lips, mouth, changes in taste, dry eye, blurred vision, and increased tearing. Inform your doctor if any of these side effects disturb or persist in you.   

Inform your healthcare provider if you are allergic to Paleno 125 mg Capsule and its ingredients. Before taking this medicine, it is vital to inform your doctor if you have any signs of infections (fever, chills, or sore throat), liver disorders, kidney disorders, or intolerance to some sugars. 

The paleno 125mg dosage typically consists of taking one 125 mg capsule once daily for 21 consecutive days followed by a 7-day break, completing a 28-day cycle. Dosage may be adjusted depending on your body's response and blood test results, so follow your doctor's instructions closely.

The paleno 125mg capsule price may vary depending on the pharmacy, location, and whether you’re purchasing as a strip or full pack. To get accurate pricing, consult a licensed pharmacy or check on trusted online medicine platforms. 

The paleno 125mg uses are:

• Treatment of hormone receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative advanced or metastatic breast cancer.

Paleno 125 mg Capsule works by blocking the protein called cyclin-dependent kinases 4 and 6, which are vital for the division and growth of cells. By blocking these proteins, this medication slows the growth and prevents the cancer cells from spreading. 

Inform your doctor about all medications, including prescribed, over-the-counter, nutritional or vitamin supplements and herbal products that you are taking or have taken before the treatment. Concurrent use of Paleno 125 mg Capsule with CYP3A4 inhibitors such as fentanyl has reported increased fentanyl toxicity. Certain medications may interact with the effectiveness of this drug.

• Keep Paleno 125 mg Capsule out of sight and reach of children.
• Store at 20°C to 25°C.

Take Paleno 125 mg Capsule exactly as prescribed by your doctor. Take this medication once a day at the same time with food. Swallow this capsule as a whole with a glass of water. Avoid crushing, breaking, or chewing the capsule. 

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. paleno capsule side effects include

Serious side effects of Paleno 125mg Capsules are:

• Blood disorder (fever, chills, shortness of breath, weakness, bleeding, or bruising)
• Lung inflammation (chest pain, dry cough, or difficulty breathing)

Common side effects of Paleno 125mg Capsules are:

• Tiredness
• Hair loss
• Dry skin, rash
• Infections
• Low blood cell counts
• Decreased of appetite
• Nausea, vomiting
• Diarrhea
• Swelling of lips and mouth
• Changes in taste
• Nose bleed
• Dry eye, blurred vision, increased tearing

• Avoid grapefruit and St. John's wort: Do not consume grapefruit, grapefruit juice, or any products containing St. John’s wort during treatment with Paleno 125 mg Capsule.

• Use birth control:

  • Females: Use effective contraception during treatment and for at least 3 weeks after the final dose.

  • Males: Use contraception for at least 14 weeks after the final dose.

• Possible fertility effects: This medicine may reduce fertility; speak with your doctor if you have concerns about future family planning.

• Regular blood tests: Your doctor may recommend routine blood tests to monitor how the medication affects your blood cells.

• Substitute options: If needed, your doctor might prescribe a suitable alternative to Paleno 125 mg Capsule 21's based on your health and treatment needs.

1. Pfizer Labs, US Food and Drug Administration, [Revised on March 2017] [ Accessed on 26 Nov 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207103s004lbl.pdf
2. Neha S Mangini et al; Palbociclib: A Novel Cyclin-Dependent Kinase Inhibitor for Hormone Receptor-Positive Advanced Breast Cancer; The Annals of Pharmacotherapy; Published on Nov 2015; Accessed on 26/11/2022; https://pubmed.ncbi.nlm.nih.gov/26324355/
3. Palbace; Pfizer; Revised on Oct 2021; Accessed on 26/11/2022; https://labeling.pfizer.com/ShowLabeling.aspx?id=14029