Proglob 5gm Injection 100ml is an immunostimulant drug containing the active ingredient Human normal immunoglobulin that belongs to the class of immunoglobulin derivatives.  It is used as a replacement therapy for individuals with primary immunodeficiency disorders (PIDs), where the body's immune system cannot produce sufficient antibodies to fight off infections. The medication is also used to modulate or regulate the immune system in certain autoimmune and inflammatory conditions. It can help reduce excessive inflammation and suppress abnormal immune responses. 

This drug is contraindicated in individuals with known hypersensitivity or allergy to human immunoglobulin or its components.There is a chance of developing blood clots during the treatment with Proglob 5gm Injection 100ml treatment hence it is recommended to monitor the blood viscosity and ensure adequate hydration. If you have a selective IgA deficiency, there is a risk of developing antibodies against IgA. In such cases, normal human immunoglobulin should be used cautiously or avoided altogether. Inform your physician if you have a history of IgA deficiency. After receiving Proglob 5gm Injection 100ml, it is possible to experience a temporary decrease in the concentration of white blood cells, a condition named as neutropenia (low neutrophil count) which resolves spontaneously within a week.  It is not recommended for children younger than 12 years since the effects of human immunoglobulin  in this population is unknown. 

The administration of normal human immunoglobulin may interfere with the effectiveness of live attenuated vaccines. It is advisable to avoid live vaccines for a certain period after receiving this drug. The overdose of Proglob 5gm Injection 100ml may lead to fluid overload, particularly in patients with pre-existing heart failure or compromised renal function. Patients with such conditions should be carefully monitored during infusion. Inform your doctor of any heart, thyroid, kidney, or liver disease. Your physician may prescribe you a low dose and perform regular blood tests. The use of this medicine during pregnancy or breastfeeding should be discussed with your physician.

• Primary immunodeficiency disease (PID)

• Chronic inflammatory demyelinating  polyneuropathy (CIDP)

• Multifocal motor neuropathy

Proglob 5gm Injection 100ml works by restoring the immunoglobulin G (IgG) antibodies. It directly binds to the Fc fragment-specific receptors and acts against inflammatory mediators. It induces cell death in B and T cells, eventually reducing inflammation and the severity of infections. It functions by replenishing the antibodies that are lacking in order to combat infections and inflammation.

Inform your physician about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Proglob 5gm Injection 100ml and cause undesirable side effects.The use of human immunoglobulins reduces the effectiveness of some vaccines like mumps, measles, rubella and chickenpox.

• Store Proglob 5gm Injection 100ml in a refrigerator (2°C- 8°C).

• Do not freeze.

Proglob 5gm Injection 100ml is usually administered through a vein (intravenously) by your physician in a hospital setting. It will be infused into your body gradually at first. After then, your doctor might progressively raise the infusion rate.Your physician will decide the correct dosage and duration based on age, body weight, blood viscosity and  other disease conditions.

Side Effects are unwanted symptoms caused by medicines. Although all medicines cause side effects, not everyone gets them.

Serious 

• Severe allergic reaction (rash, itching, swelling of lips, tongue, wheezing, difficulty breathing, low blood pressure with confusion, dizziness, fainting)

• Meningitis (inflammation of the brain)

• Respiratory failure

• Migraine

• High blood pressure

• Blood clot in lungs

• Rupturing of red blood cells

Common 

• Rash

• Itching

• Wheezing

• Difficulty in breathing

• Swelling of the eyelids

• Fever

• Confusion

• Dizziness

• Low BP

1. Inform your physician if you have a current or past history of kidney disorders before taking Proglob 5gm Injection 100ml.

2. Your doctor will closely monitor kidney function throughout the treatment.

3. Maintain a well-balanced diet and avoid driving or operating machines if you feel dizzy or tired.

4. Adhere to the prescribed infusion rate, as a rapid infusion may cause side effects such as headache, flushing, chills, muscle pain, wheezing, rapid heartbeat, back pain, nausea, or low blood pressure.

5. Inform your doctor that this medicine may affect certain laboratory test results.

6. Regular monitoring of urine output and renal function is recommended during treatment.