• Treatment of Human Immunodeficiency Virus 1 (HIV-1) Infection

Taftrio Tablet combines integrase strand transfer inhibitors and nucleoside, nucleotide analogue reverse transcriptase inhibitors. It increases the number of CD4 T cells and stimulates the immune system to fight against infections. Thereby, it reduces the viral load of HIV in the blood and decreases the severity of HIV infection.

Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Taftrio Tablet and can cause undesirable side effects.

• Store Taftrio Tablet at room temperature below 30°C.
• Keep out of sight and reach of pets and children.

Take the Taftrio Tablet as advised by your physician. Swallow the tablets whole and intact. This tablet should be taken with food. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the medicine if your doctor advises you to stop.

Side Effects are unwanted symptoms caused by medicines. Although all medicines cause side effects, not everyone gets them.

Serious

• Bone loss
• Worsening of Hepatitis B
• Kidney injury
• Immune reconstitution syndrome
• Lactic acidosis
• Liver toxicity

Common

• Depression
• Abnormal dreams
• Headache
• Dizziness
• Diarrhea
• Feeling sick (Nausea)
• Tiredness (Fatigue)

To prevent the spread of HIV-1 infection, avoid sharing needles or syringes, which can transmit HIV-1 infections easily. It's necessary for individuals who use injectable drugs to use sterile needles and syringes and never share them with others. Personal items like toothbrushes, razor blades, or anything with body fluids or blood should also be avoided. They should not be shared because HIV-1 can be present in blood and certain body fluids, and sharing these items could mainly transmit the virus. Do not have any sex without protection. It is necessary to practice safe sex using a polyurethane condom or latex to lower the risk of sexual contact with semen, vaginal secretions, or blood.

If you remember to take a Taftrio Tablet for the entire day, take your usual dose the next day. However, do not double-dose yourself. Do not store this tablet in a moist place like a bathroom cabinet or near the kitchen sink. Keep your tablet in a tightly closed container. Do not accept if the seal over the bottle opening is broken or missing. This medicine was prescribed for your specific condition. Please do not use it for other conditions. Do not give this tablet to others, even if they have the same symptoms like you have. It may harm them.

1. Gilead Sciences Inc., U.S. Food and Drug Administration (EMC), [Revised on Oct 2021] [Accessed on 20th May 2023], https://www.medicines.org.uk/emc/files/pil.9313.pdf
2. KD Tripathi, Antiviral Drugs (Anti-retrovirus), Essentials of Medical Pharmacology, 8th Edition, 2019, 860-872.
3. Goodman & Gilman's, The Pharmacological Basis of Therapeutics, Antiretroviral agents and treatment of HIV infection, 12th Edition, 2011, 1634-1638.