TENOF EM TABLET

Introduction:

Tenof EM Tablet contains two active substances, Emtricitabine 200mg and Tenofovir disoproxil 300mg. It is a combination drug regimen that is commonly used for the effective treatment of HIV-1 infection. 

Antiviral drugs are beneficial in postponing the complications related to AIDS and improving the overall quality of life. This combinational therapy is highly suitable for patients with large viral load. Although this drug reduces the risk of viral infection to a great extent, this does not cure HIV and there is still a possibility of transmitting HIV to other people.

Lactic acidosis is a rare but life threatening side effect of this medicine that occurs in overweight women and people with liver disease. Watch out for symptoms like deep rapid breathing, drowsiness, nausea, vomiting and stomach pain.

Uses of Tenof EM Tablet:

• Treatment of HIV-1 infection in adults and children above 12 years of age weighing more than 35kgs.

How Tenof EM Tablet works:

The reverse transcriptase enzyme is responsible for producing copies of DNA from the HIV’s RNA. Emtricitabine gets converted into its triphosphate form by the kinase enzymes as soon as it reaches inside the cell and inhibits reverse transcriptase enzyme. Tenofovir is the only nucleotide analog and it has a high tolerability. The inhibition of reverse transcriptase enzyme ultimately blocks the replication and reproduction of the virus.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Store protected from moisture, at a temperature not exceeding 30°C.keep container tightly closed and away from the reach of children.

References:

1. Tillomed Laboratories Limited, Electronic Medicines Compendium (EMC), [Revised on Apr 2020] [Accessed on 19th Jul 2021], https://www.medicines.org.uk/emc/files/pil.11636.pdf
2. KD Tripathi, Antiviral Drugs (Anti-retrovirus), Essentials of Medical Pharmacology, 8th Edition, 2019, 860-872.

How to use Tenof EM Tablet:

Take one tablet each day with food. If you have difficulty swallowing, crush the tablet, mix the powder in 100ml water or orange juice and drink immediately.

Safety Advice:

Pregnancy:

Inform your physician before starting this treatment if you are pregnant or think you might be pregnant. 

Breastfeeding: 

Consult your physician for advice before taking this medicine if you are breastfeeding your child. Your physician might suggest you to stop breastfeeding as this medicine passes through breast milk.

Liver:

Inform your physician before starting this treatment if you have liver disease, hepatitis B or hepatitis C. Your physician will monitor your liver functions and prescribe accordingly.

Kidney:

Inform your physician before starting this treatment if you have kidney diseases. Your physician will monitor your kidney functions and prescribe accordingly.

Driving: 

Do not drive and do not use any tools as this medicine could cause dizziness.

Allergies: 

Inform your physician if you experience allergic reactions to Emtricitabine, Tenofovir Disoproxil Fumarate, peanut, soya or other ingredients.

Others:

• Do not share or re-use needles or other injections. Avoid sharing personal items like toothbrushes, razor blades with others. Do not have unprotected sex. 
• Get tested for other sexually transmitted diseases like syphilis and gonorrhoea.
• Inform your physician if you have bone problems or other medical conditions.
• Talk to your physician if you are below 12 or over 65 years of age.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Deep rapid breathing, drowsiness, nausea, vomiting, stomach pain
• Infection or inflammation
• Weakness, palpitation, tremor or hyperactivity
• Allergic reactions

Common:

• Diarrhea
• Dizziness, headache
• Rash
• Low phosphate and high creatine kinase levels in blood
• Difficulty sleeping, abnormal dreams
• Digestion problems
• Liver and pancreas problems