Trilavir Mini Tablet uses are

• Treatment of HIV infections

The reverse transcriptase enzyme produces copies of the DNA of HIV. Lamivudine and Tenofovir are Nucleoside reverse transcriptase inhibitors. Efavirenz is a Nonnucleoside Reverse Transcriptase Inhibitor that directly inhibits the enzyme reverse transcriptase. This blocks the replication and reproduction of the virus.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications interact with Trilavir mini tablet and reduce its effectiveness by causing undesirable side effects.

• Antacids (Moderate to Severe) - Medicines such as aluminum hydroxide, magnesium hydroxide, or calcium carbonate may reduce the absorption of Trilavir Mini Tablet. Take antacids at least 2 hours before or after taking this medication.

• Anticonvulsants (Severe) - Medicines such as phenytoin, carbamazepine, or phenobarbital may reduce the effectiveness of efavirenz and increase the risk of treatment failure. Your doctor may need to adjust dosages or monitor closely.

• Antimycobacterials (Severe) - Rifampicin and rifabutin may significantly reduce the blood levels of efavirenz and other components. Alternative treatments or dose adjustments may be necessary.

• Antifungal Medicines (Moderate) - Drugs like voriconazole, itraconazole, or ketoconazole may interact with Trilavir Mini Tablet, affecting blood levels of both medications. Your doctor will monitor and adjust dosages if needed.

• St. John's Wort (Severe) - This herbal supplement can significantly reduce the effectiveness of Trilavir Mini Tablet and lead to treatment failure or viral resistance. Avoid use during treatment.

• Warfarin and Anticoagulants (Moderate) - Blood thinners may have altered effects when taken with this medication. Regular monitoring of blood clotting times is recommended.

• Contraceptive Pills (Moderate) - Hormonal contraceptives may become less effective when taken with efavirenz. Additional barrier contraception methods are recommended.

• Store at 30°C.

• Protect the medicine from light and excessive moisture.

• Keep the medicine out of reach of children and pets.

It is an orally available prescription drug. Your doctor will decide the dose and duration of Trilavir mini tablet tablet based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. Take the tablet at the same time. Do not take an additional dose to compensate for the missed dose.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Trilavir Mini Tablet side effects are

Serious:

• Rapid breathing

• Drowsiness

• Nausea, vomiting, and stomach pain

• Severe allergic reactions

• Severe mood disturbances, depression, and suicidal thoughts

• Confusion, forgetfulness, seizures, and tremor

• Liver toxicity

• Kidney damage

• Autoimmune disorders

Common:

• Bloating, flatulence

• Headache

• Sleeplessness

• Skin reactions

• Wheezing, swelling, or lightheadedness

• Hair loss

• Diarrhea

• Bone disorders

• Weakness

• Anemia

• Inform your doctor about any underlying infections you may have before starting treatment.

• If you have advanced HIV (AIDS), be aware that you may develop signs of infection and inflammation once treatment begins, or experience worsening of existing infection symptoms.

• Report any side effects to your doctor immediately.

• It is essential to inform your medical professional if you are taking any other medications that may harm your kidneys.

• Always consume only the dose recommended by your doctor; never adjust the dosage yourself.

1. Macleods Pharmaceuticals Limited, US Food and Drug Administration, [Revised on Mar 2019] [Accessed on 23rd Apr 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210649s000lbl.pdf
2. Clinical info HIV.gov, Efavirenz / Lamivudine / Tenofovir Disoproxil Fumarate - Patient | NIH (hiv.gov)
3. KD Tripathi, Antiviral Drugs (Anti-retrovirus), Essentials of Medical Pharmacology, 8th Edition, 2019, 860-872.