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Virolfi 450mg Tablet
Last updated on 20 Apr 2026 | 07:15 AM (IST)
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Introduction to Virolfi 450mg Tablet
Virolfi 450mg tablet is an Antiviral with an active ingredient called Valganciclovir. It belongs to the medication group known as Antiviral (Non-HIV) drugs. Valganciclovir is converted into Ganciclovir after entering the body, which acts to fight viral infections. It is used to treat Cytomegalovirus (CMV) infections of the retina of the eye in adults with Acquired immune deficiency syndrome (AIDS). Cytomegalovirus infection often leads to vision problems and blindness. Additionally, it prevents Cytomegalovirus (CMV) infections in patients who received an organ transplant from a person infected with CMV in adults and children.
Do not take this drug if you are allergic to Valganciclovir, Ganciclovir, and its other ingredients. Inform your physician if you have a lower blood cell count ( WBC, RBC, Platelet). Notify your doctor if you took any radiotherapy or hemodialysis (a treatment to filter wastes and water from your blood) or conditions with your kidney. Inform your physician if you are pregnant or planning to get pregnant. Use effective contraception during and even after the treatment; women should use contraception for 30 days, whereas men should use condoms for 90 days during and after the treatment. Discuss with your doctor for more fertility concerns. A dosage adjustment of Virolfi 450mg tablet will be given if you have kidney conditions. Your doctor may regularly take the blood test to monitor the blood count while taking the tablet.
Uses of Virolfi 450mg Tablet
- Treatment and prevention of Cytomegalovirus (CMV) infection
Therapeutic Effects of Virolfi 450mg Tablet
Virolfi 450mg tablet is an antiviral medication. After administration, liver enzymes rapidly convert the Virolfi 450mg tablet into Ganciclovir. Ganciclovir prevents virus growth by inhibiting viral DNA synthesis.
Interaction of Virolfi 450mg Tablet with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Virolfi 450mg tablet and can cause undesirable side effects.
More Information about Virolfi 450mg Tablet
- Keep out of sight and reach of pets and children
- Store at room temperature between 15°C to 30°C.
- Do not freeze.
How to consume Virolfi 450mg Tablet
Take the Virolfi 450mg tablet as advised by your physician. Swallow the tablets whole and intact. This tablet should be taken with food. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the medicine if your doctor advises you to stop.
Safety Advice for Virolfi 450mg Tablet
Breast Feeding
Taking Virolfi 450mg tablet while breastfeeding may be unsafe because it may affect the child. Talk to your physician to get more information.
Alcohol
It is unknown whether consuming alcohol while taking a Virolfi 450mg tablet is safe. Please speak with your physician.
Liver
It is unknown whether Virolfi 450mg tablet is safe to administer in patients with liver problems. Inform your physician if you have any liver disease before starting the treatment. Contact your doctor if you experience any liver-related symptoms.
Lungs
It is unknown whether Virolfi 450mg tablet is safe to administer in patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
Driving
While taking Virolfi 450mg tablet , it is unsafe to drive or use machines because it may cause dizziness, shaky, changes in vision, etc. Talk to your doctor for more information.
Pregnancy
Taking Virolfi 450mg tablet while pregnant can harm the baby. You should not take this medicine during the pregnancy unless your doctor recommends taking it. Inform your doctor if you are pregnant or planning to get pregnant before taking this medicine. Use effective contraception to avoid pregnancy.
Side Effects of Virolfi 450mg Tablet
Side Effects are unwanted symptoms caused by medicines. Although all medicines cause side effects, not everyone gets them.
Serious
- Anaphylactic shock (sudden swelling of the throat, face, lips, hand, ankles, difficulty swallowing, itchy skin rash)
- Low blood counts (shortness of breath, pale skin, mouth ulcers, sore throat)
- Blood infection
- Severe stomach pain which spreads into your back
- Seizures
Common
- Respiratory tract infections
- Loss of appetite
- Headache, Dizziness
- Cough, fever
- Diarrhea, constipation
- Tiredness, feeling sick
- Infections in the urinary tract, skin
- Weight loss
- Anxious, confused, depression
- Troubled sleeping
- Abnormal sensation of skin (tickling, pricking, burning, tingling)
- Changes in taste
- Eye, ear pain
- Night sweats
- Joint pain, muscle spasms
- Hair loss
- Low blood pressure
Word of Advice
Discuss effective contraception methods with your doctor, along with fertility concerns. Do not stop the medicine until your doctor advises. Notify your doctor if you experience any serious side effects. Inform your physician if you have liver problems because Virolfi 450mg tablet should be used cautiously with this condition. You are doctor may change your dosage based on your kidney function.
FAQs about Virolfi 450mg Tablet
Q1.
Should I use contraception during and after the treatment of the Virolfi 450mg tablet?
Yes, it is advised to use contraception during and after the treatment to avoid unwanted pregnancy. Both women and men are advised to use contraception. After the treatment, it is suggested to use condoms for 30 days in women and 90 days in men.
Q2.
What can be done to manage side effects while taking Virolfi 450mg Tablet?
If you experience any side effects while taking Virolfi 450mg Tablet, contact your doctor immediately. They may adjust your dosage or recommend supportive medications to ease the symptoms and help you continue treatment safely.
Q3.
What is the recommended duration for taking Virolfi 450mg Tablet?
The length of treatment with Virolfi 450mg Tablet depends on your medical condition and how you respond to the medication. Your doctor will decide the appropriate dosage and duration. Do not stop the medication unless your doctor advises you to.
Q4.
Can patients with impaired kidney function use Virolfi 450mg tablet?
Virolfi 450mg tablet should be used cautiously in individuals with impaired kidney function. Dose adjustments may be necessary, and close monitoring of kidney function is important.
Q5.
Is it safe to drink alcohol while taking Virolfi 450mg tablet?
It is unknown whether consuming alcohol while taking Virolfi 450mg tablet is safe. Drinking alcohol while consuming the medicine is generally not recommended as alcohol may increase the risk of certain side effects, such as dizziness or drowsiness, associated with the medicine. Talk with your doctor for more information.
Fact Box of Virolfi 450mg Tablet
| Molecule Name: Valganciclovir | Therapeutic class: Anti-infection |
| Pharmacological class: Antiviral (Non-HIV) drugs | Indications: Treatment and prevention of Cytomegalovirus (CMV) infection |
References
- KD Tripathi, Essentials of Medical Pharmacology, Antiviral drugs, 7th edition, 2013, 801.
- Roche Products Limited, Electronic medicines compendium (EMC), [ Revised on April 2022] [ Accessed on 11th May 2023], pil.13566.pdf (medicines.org.uk)
- Genentech USA, US Food and Drug Administration, [ Revised on Aug 2010] [ Accessed on 11th May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021304s008,022257s003lbl.pdf
Disclaimer
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Author Details
Written By
Aswini Priya Velmurugan
PG in Biotechnology
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 20 Apr 2026 | 07:15 AM (IST)
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