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Vonaz 200mg Injection
Last updated on 31 Mar 2026 | 09:30 AM (IST)
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Introduction to Vonaz 200mg Injection
Vonaz 200mg injection is an antifungal drug that contains an active ingredient called Voriconazole. It belongs to the medication class known as fungal ergosterol synthesis inhibitor. It is prescribed for severe, life-threatening fungal infections and as a preventive measure for high-risk individuals, including those who have undergone bone marrow transplantation. This medicine should not be given to children younger than 2 years of age. Ā
Do not take this medicine if you are allergic to Voriconazole or other medical ingredients. Before taking Vonaz 200mg injection, it is important to notify your doctor if you have had an allergic reaction to other azoles, suffer from or have a history of liver disease, or have cardiomyopathy, irregular heartbeat, slow heart rate, or an abnormality of the electrocardiogram (ECG) called 'long QTc syndrome'. Additionally, it is crucial to avoid sunlight and sun exposure during treatment, protecting the skin with clothing and high-SPF sunscreen. Children should also follow these precautions. Some common side effects include fever, rash, nausea, vomiting, diarrhea, headache, swelling of the extremities, stomach pain, and breathing difficulties.Ā
While on this medicine, promptly inform your doctor if you experience a sunburn, severe skin rash or blisters, bone pain, signs of adrenal insufficiency (chronic fatigue, muscle weakness, appetite loss, weight loss, abdominal pain), or signs of Cushing's syndrome (weight gain, fatty hump, rounded face, darkened skin, thinning skin, easy bruising, high blood sugar, excessive hair growth, excessive sweating). Inform your doctor if you have a known intolerance to certain sugars before taking Vonaz 200mg injection because this medicine contains lactose.Ā
Uses of Vonaz 200mg Injection
- Invasive Aspergillosis
- Candidemia in non-neutropenic patients
- Esophageal candidiasis
- Fungal infections (caused by Scedosporium apiospermum, Fusarium spp., and Fusarium solani)
- Candida infections
- Fungal infections in high-risk bone marrow transplant patients
Therapeutic Effects of Vonaz 200mg Injection
Vonaz 200mg injection works by blocking the production of ergosterol, disrupting fungal cell membranes and leading to cell death, ultimately eliminating the infection.
Interaction of Vonaz 200mg Injection with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Vonaz 200mg injection and can cause undesirable side effects.
More Information about Vonaz 200mg Injection
- Keep out of sight and reach of pets and children.
- Do not freeze the medicine.
- Medicine should be used immediately, but if necessary may be stored for up to 24hrs at 2Ā°C - 8Ā°C.
- Always check the expiry date before consuming it.
How to consume Vonaz 200mg Injection
Vonaz 200mg injection will be administered to you by a healthcare professional in a hospital setting. It is usually administered in muscle or vein (intravenous). Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors.
Safety Advice for Vonaz 200mg Injection
Breast Feeding
Limited information is available on using Vonaz 200mg injection during breastfeeding. So, before starting the treatment, inform your doctor if you are breastfeeding. Contact your doctor for more information.Ā
Alcohol
It is unsafe to consume alcohol while taking Vonaz 200mg injection.Ā
Liver
Vonaz 200mg injection should be used cautiously in liver patients. Before starting the treatment, notify your doctor about pre-existing liver conditions. Dose adjustment is needed in such conditions. Your doctor will check your liver to monitor its functions.Ā
Lungs
It is unknown whether Vonaz 200mg injection is safe for patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
Driving
Vonaz 200mg injection could alter the driving ability or operating machinery capacity by causing blurred vision or uncomfortable sensitivity to light.
Pregnancy
Avoid taking Vonaz 200mg injection during pregnancy unless directed by your doctor. Use effective contraception and notify your doctor immediately if you become pregnant while taking medicine.
Side Effects of Vonaz 200mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Rash
- Visual disturbances
- Liver problems
- Arrhythmias and QT prolongation
- Jaundice (Changes in blood tests of liver function)
- Pancreatitis (inflammation of the pancreas)
Common
- Fever, headache
- Nausea, vomiting, diarrhea
- Swelling of the extremities
- Itchiness and rashes
- Sinusitis
- Pain in the stomach, back
- Blood in urine
- Seizures
- Low BP
- Hair loss
- Low levels of glucose, sodium, potassium, WBC, platelet
- Neutrophil counts in the blood.
Word of Advice
Liver and heart patients should take Vonaz 200mg injection cautiously and inform their doctor about all the underlying medical conditions. Do not stop the medicine until your doctor advises. Do not double-dose the medicine to make up for a forgotten dose.Ā
Unless your doctor advises, do not consume this medicine if you are pregnant or breastfeeding while taking Vonaz 200mg injection. Notify your doctor if you experience any serious side effects. Your medical professional will inform you if you need any dose adjustments. Contact your doctor for more information.
FAQs about Vonaz 200mg Injection
Q1.
How does Vonaz 200mg injection work?Ā
Vonaz 200mg injection inhibits ergosterol production, disrupting fungal cell membranes and leading to cell death, thereby eliminating the infection and relieving symptoms.Ā
Q2.
Can you take Vonaz 200mg injection when pregnant?Ā Ā
Consult your medical professional regarding the use of Vonaz 200mg injection during pregnancy. The potential benefits and risks should be carefully assessed. Your doctor will suggest taking this medicine only if it's necessary. Ā
Q3.
How long does Vonaz 200mg injection take to work?Ā
The effectiveness of Vonaz 200mg injection can vary among individuals and depends on the specific fungal infection being treated. While some people may experience symptom improvement within a few days, others may require several weeks to see noticeable results. Discuss with your doctor for more information. Ā
Q4.
What should I do if I miss a dose of Vonaz 200mg injection?Ā
If you miss an injection dose, take it as soon as possible. However, if it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose the Vonaz 200mg injection.Ā
Q5.
What are the side effects of Vonaz 200mg injection?Ā
Some common side effects of Vonaz 200mg injection are nausea, vomiting, diarrhea, swelling of the extremities, itchiness and rashes, sinusitis, pain in the stomach and back, blood in urine, seizures, and hair loss.Ā
Fact Box of Vonaz 200mg Injection
| Molecule Name: VoriconazoleĀ | Therapeutic class: Antifungal drug |
| Pharmacological class: Fungal ergosterol synthesis inhibitor | Indications:Ā 1. Invasive Aspergillosis 2. Candidemia in non-neutropenic patients 3. Esophageal candidiasis 4. Fungal infections (caused by Scedosporium apiospermum, Fusarium spp., and Fusarium solani) 5. Candida infections 6. Fungal infections in high-risk bone marrow transplant patients |
References
- Pfizer, Electronic Medicines Compendium (EMC), [Revised on Jul 2021] [Accessed on 02nd June 2023], https://www.medicines.org.uk/emc/files/pil.7976.pdf
- D.H. Dockrell, S. Sundar, B.J. Angus, R.P. Hobson, Infectious disease, Davidsonās Principles and Practice of Medicine, 22nd Edition, 2014, 293-386.
- Istituto Biochimico Italiano G. Lorenzini S.p.A., Electronic Medicines Compendium (EMC), [Revised on March 2022] [Accessed on 02nd June 2023] pil.11014.pdf (medicines.org.uk)
Disclaimer
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Author Details
Written By
Dr. Bhairavi S
Pharm. D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:30 AM (IST)
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