Winrevair 45mg uses for:

• Treatment of pulmonary arterial hypertension (PAH) in adults

• Improvement in exercise ability and physical activity

• Reduction in symptoms such as breathlessness, fatigue, and chest discomfort

• Slowing the progression of PAH

• Lowering the risk of hospitalisation due to worsening condition

It is often used alongside other PAH medications for better disease control.

Winrevair 45mg Injection belongs to a class of medicines known as activin receptor signalling inhibitors.

In patients with PAH, there is an imbalance in certain cellular pathways that leads to narrowing and thickening of blood vessels in the lungs. This increases resistance to blood flow and raises blood pressure in the pulmonary arteries.

This medicine works by:

• Blocking abnormal activin signalling pathways

• Restoring balance between cell growth and repair

• Reducing excessive cell proliferation in lung blood vessels

• Improving the structure and function of pulmonary arteries

As a result, it lowers lung blood pressure and reduces strain on the heart.

Winrevair 45mg Injection may interact with certain medicines, especially those affecting blood clotting.

Moderate Interaction

• Anticoagulants (blood thinners): May increase the risk of bleeding

• Antiplatelet medicines: Can enhance bleeding tendency

Mild to Unknown Interaction

• Other pulmonary arterial hypertension medications

• Herbal supplements that affect clotting mechanisms

Always inform your doctor about all medicines, supplements, and herbal products you are taking to avoid potential risks.

• Store in a refrigerator at 2°C to 8°C

• Do not freeze

• Keep in original packaging to protect from light

• Use the prepared solution within 4 hours

• Keep out of reach of children

Do not use if the medicine appears discoloured or contains particles.

Winrevair 45mg Injection is administered as a subcutaneous injection under the supervision of a healthcare professional.

• Starting dose: 0.3 mg/kg of body weight

• Maintenance dose: May be increased to 0.7 mg/kg based on patient response

• Frequency: Once every 3 weeks

The dosage may be adjusted depending on laboratory results, especially haemoglobin and platelet levels. Patients should follow their doctor’s instructions strictly and should not change the dose on their own.

Like all medicines, Winrevair 45mg Injection can cause side effects.

Common Side Effects

• Headache

• Nosebleeds

• Skin rash or redness

• Diarrhoea

• Dizziness

• Visible small blood vessels on the skin

These effects are usually mild and temporary.

Serious Side Effects

• Severe bleeding episodes

• Increased red blood cell count (erythrocytosis)

• Low platelet levels (thrombocytopenia)

• Risk of blood clots due to thickened blood

Seek immediate medical help if you experience:

• Unusual bleeding or bruising

• Black stools or blood in stools

• Severe headache or vision problems

• Sudden weakness or confusion 

• Attend all scheduled appointments for blood tests to monitor haemoglobin and platelet levels

• Inform your doctor immediately if you notice any signs of bleeding or bruising

• Stay well hydrated and maintain a healthy lifestyle to support treatment outcomes

• Avoid activities that may increase the risk of injury or bleeding

• Do not miss scheduled doses and follow the injection timeline strictly

• Inform your doctor if you are planning pregnancy or undergoing any surgery

• Keep track of any unusual symptoms and report them promptly