Quick Summary
Zolfrac 5mg Injection
Last updated on 31 Mar 2026 | 09:31 AM (IST)
₹1717
MRP: ₹3815
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1 VIAL(s) OF 100ML
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₹1717
MRP: ₹3,815.00
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Introduction
Zolfrac 5mg Injection contains Zoledronic Acid, a medicine used to treat high calcium levels in the blood caused by cancer and bone-related conditions. It belongs to a group of medicines called bisphosphonates, which work by slowing bone breakdown and strengthening weak bones. Doctors also use Zolfrac injection for osteoporosis in men and postmenopausal women to reduce fracture risk, and for Paget’s disease, where bones become soft or deformed.
The injection is given by a healthcare professional through a vein. Your doctor will decide the Zolfrac 5mg Injection dosage based on your medical condition. Staying well-hydrated before and after treatment is important to protect your kidneys. You may also need regular blood tests to monitor calcium levels and kidney function.
Patients can check the Zolfrac 5mg price in India or buy Zolfrac 5mg injection online from verified pharmacies. It is also used as a Zolfrac injection for hypercalcemia and has substitutes available under a doctor’s advice. Always follow medical guidance for safe use.
Uses
Zolfrac Injection uses are
Treat hypercalcemia of malignancy
Multiple myeloma
Bone metastases from solid tumors
Osteoporosis in postmenopausal women
Osteoporosis in men
Paget’s disease of bone
How Zolfrac 5mg Injection works
Zolfrac 5mg primarily inhibits bone resorption. It works by slowing bone breakdown, increasing bone density (thickness), and decreasing the amount of calcium released from the bones into the blood.
Interaction of Zolfrac 5mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications like aminoglycosides, loop diuretics, and nephrotoxic drugs may interact with Zolfrac 5mg Injection and reduce its effectiveness by causing undesirable side effects.
Storage conditions
Store Zolfrac 5mg Injection at room temperature (20°C to 25°C)
keep the injection away from the reach of children and pets.
If you have missed any dosing appointments, inform your doctor and schedule immediately.
How to use Zolfrac 5mg Injection
It should only be administered by a trained doctor or nurse. It will be given as a drip (infusion) into your vein. Your doctor will decide the dose and duration of the treatment based on your disease severity and other factors. Do not self-administer the medication.
Safety Advice for Zolfrac 5mg Injection
Breast Feeding
Breastfeeding is not recommended in patients taking Zolfrac 5mg Injection because the medicine passes into the breast milk in small amounts and may harm your baby.
Alcohol
Caution is advised when consuming alcohol with Zolfrac 5mg Injection. Please consult your doctor.
Liver
It is unknown whether Zolfrac 5mg Injection can be used in patients with liver disorders. Inform your physician if you have liver problems before initiating the therapy.
Lungs
It is unknown whether Zolfrac 5mg Injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment. s.
Driving
It is unsafe to drive or operate heavy machinery after using Zolfrac 5mg Injection as this medicine causes drowsiness and sleepiness,
Pregnancy
Zolfrac 5mg Injection is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Zolfrac injection side effects are
Common
Nausea, vomiting
Fatigue
Anemia
Bone pain
Constipation, diarrhea
dyspnea, and fever
Swelling in the legs and feet
Decreased weight
Abdominal pain
Muscle pain
Tiredness
Serious
Changes in heart rhythm
Severe hypersensitivity skin reactions
Decreased calcium levels
Severe bone pain
Severe kidney problems
Unusual fractures of the bone
Expert tips
Maintain good oral hygiene throughout the treatment.
Schedule and attend regular dental check-ups.
Contact your doctor or dentist immediately if you notice any of the following:
Loose teeth
Mouth or jaw pain
Swelling or inflammation in the gums
Non-healing sores or ulcers
Any discharge or infection around the mouth or teeth
Inform your doctor if you have any existing kidney problems, as the dose or treatment plan may need adjustment.
Your doctor may recommend regular blood tests to monitor your body’s response and ensure the treatment is working effectively.
FAQs about Zolfrac 5mg Injection
Q1.
What symptoms should I notify the doctor of when taking Zolfrac 5mg Injection?
Notify your healthcare provider immediately if you experience symptoms of hypocalcemia (low calcium levels), such as muscle spasms, twitches, cramps, or numbness or tingling in fingers, toes, or the area around your mouth. You should also notify your doctor if you experience symptoms of a fracture or severe bone, joint, or muscle pain.
Q2.
Can Zolfrac 5mg Injection affect the heart?
Severe side effects of Zolfrac 5mg Injection include cardiovascular problems like atrial fibrillation, bradycardia, hypotension, or hypertension.
Q3.
Is Zolfrac 5mg Injection toxic to the liver?
Limited information is available on the liver's safety in patients receiving Zolfrac 5mg Injections. Inform your physician if you have any liver disorders.
Q4.
Does Zolfrac 5mg Injection strengthen bones?
Zolfrac 5mg Injection is an osteoporosis medication that can help strengthen your bones and reduce your risk of breaking a bone.
Q5.
Is there an alternative to Zolfrac 5mg Injection Injection?
Zolfrac 5mg Injection belongs to the class bisphosphonates. Bisphosphonates can also be given as tablets; ask your doctor about this. Inform your doctor before switching to any alternative medicines.
Fact Box of Zolfrac 5mg Injection
Molecule name | Zoledronic Acid |
Therapeutic class | Calcium Regulator |
Pharmacological class | Bisphosphonates |
Indications | 1. Treat hypercalcemia of malignancy 2. Multiple myeloma 3. Bone metastases from solid tumors 4. Osteoporosis in postmenopausal women 5. Osteoporosis in men 6. Paget’s disease of bone |
References
- Zoledronic acid 5 mg solution for infusion - Patient Information Leaflet (PIL) - (emc). www.medicines.org.uk. [revised on 2017] [cited 2023 Mar 28]. Available from: https://www.medicines.org.uk/emc/product/5242/pil
- HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use zoledronic Injection safely and effectively. See full prescribing information for zoledronic Injection. zoledronic Injection for intravenous use. [Revised on 2017] [cited 2023 Mar 28]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/203231s011lbl.pdf
- KD Tripathi, Hormones and Drugs Affecting Calcium Balance, Essentials of Medical Pharmacology, 8th Edition, 2019, 360-372.
Disclaimer
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Author Details
Written By
Dr. Karpagam A.
Pharm D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:31 AM (IST)
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