Quick Summary
Zyrifa 120 Injection
Last updated on 29 Sep 2026 | 05:02 AM (IST)
₹9996
MRP: ₹12495
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1 VIAL(s)
Zyrifa 120 Injection
Salt Composition
DENOSUMABMarketer
BAYER ZYDUS PHARMA PVT LTD
Prepaid Only. Non-Returnable.
20% OFF
₹9996
MRP: ₹12,495.00
Inclusive of all taxes
20% Off
Salt Composition
DENOSUMABMarketer
BAYER ZYDUS PHARMA PVT LTD
Prepaid Only. Non-Returnable.
Dispatch: Today
Care delivered without the wait. Your order is prioritized for rapid dispatch to ensure it reaches your doorstep on time.
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Introduction
Zyrifa 120 Injection contains Denosumab 120 mg/1.7 mL. It is a prescription medicine used to help prevent serious bone complications in people with cancer involving the bones and to treat giant cell tumour of bone when surgery is not suitable or may cause severe complications. It is administered as a subcutaneous injection under the supervision of a healthcare professional.
Uses of Zyrifa 120 Injection
Zyrifa 120 Injection is used for:
Preventing skeletal-related events in people with multiple myeloma
Preventing skeletal-related events in people with bone metastases from solid tumours
Treating giant cell tumour of bone when surgery is not suitable or may cause severe complications
Your doctor will decide the dose and duration of treatment based on your condition.
How Zyrifa 120 Injection Works
Zyrifa 120 Injection contains Denosumab, which blocks a protein called RANKL (Receptor Activator of Nuclear Factor Kappa-B Ligand). This slows the activity of osteoclasts, the cells responsible for breaking down bone, helping reduce bone loss and lower the risk of bone-related complications.
Interactions of Zyrifa 120 Injection with Other Medicines
Tell your doctor about all the medicines and supplements you are taking before starting treatment.
Other medicines containing Denosumab should not be used together with Zyrifa 120 Injection.
Medicines that affect calcium levels may increase the risk of low calcium.
Your doctor may recommend calcium and vitamin D supplements during treatment.
Storage Conditions
Store in a refrigerator at 2°C to 8°C.
Do not freeze.
Keep the vial in its original carton to protect it from light.
Do not shake the vial.
Keep out of reach of children.
How to Use Zyrifa 120 Injection
Zyrifa 120 Injection is given as a subcutaneous injection by a healthcare professional.
Do not self-administer unless instructed by your doctor.
Follow your prescribed treatment schedule.
Your doctor may recommend calcium and vitamin D supplements and monitor your calcium levels during treatment.
Safety Advice
Pregnancy
Zyrifa 120 Injection is generally not recommended during pregnancy unless your doctor decides it is necessary.
Breast Feeding
It is not known whether Denosumab passes into breast milk. Speak to your doctor before breastfeeding.
Lungs
Seek medical attention if you develop difficulty breathing or signs of a severe allergic reaction after receiving the injection.
Liver
No routine dose adjustment is generally required for liver impairment, but your doctor will assess your overall condition.
Alcohol
There is no known direct interaction with alcohol. Your doctor will advise what is appropriate for you.
Driving
Avoid driving if you experience dizziness or fatigue after receiving the injection.
Side Effects
Like all medicines, Zyrifa 120 Injection can cause side effects, although not everyone experiences them.
Common side effects
Bone, joint, or muscle pain
Back pain
Fatigue
Nausea
Diarrhoea
Injection-site reactions
Serious side effects
Seek immediate medical attention if you develop:
Severe low calcium levels with muscle cramps, tingling, or seizures
Severe allergic reactions
Persistent jaw pain or poor healing after dental procedures
New or unusual pain in the thigh, hip, or groin
Expert Tips
Receive Zyrifa 120 Injection only from a healthcare professional.
Take calcium and vitamin D supplements as prescribed.
Maintain good oral hygiene during treatment.
Tell your dentist that you are receiving Denosumab before dental treatment.
Report persistent jaw pain, loose teeth, or poor healing in the mouth.
Inform your doctor if you have severe kidney disease or are receiving dialysis.
Do not stop treatment without consulting your doctor.
FAQs
Q1.
What is Zyrifa 120 Injection used for?
Zyrifa 120 Injection is used to help prevent bone complications in people with multiple myeloma or cancer that has spread to the bones. It is also used to treat giant cell tumour of bone when surgery is not suitable.
Q2.
How is Zyrifa 120 Injection administered?
It is given as a subcutaneous injection by a healthcare professional.
Q3.
Can people with kidney problems receive Zyrifa 120 Injection?
Yes. People with severe kidney disease may have a higher risk of low calcium levels and may need closer monitoring during treatment.
Q4.
What should I tell my doctor before receiving Zyrifa 120 Injection?
Tell your doctor if you have low calcium levels, kidney disease, dental problems, previous allergic reactions to Denosumab, or if you are taking any medicines or supplements.
Q5.
Can Zyrifa 120 Injection affect dental health?
Yes. Denosumab has been associated with osteonecrosis of the jaw. Maintaining good oral hygiene and informing your dentist before dental procedures can help reduce this risk.
Q6.
Does Zyrifa 120 Injection need refrigeration?
Yes. Store Zyrifa 120 Injection in a refrigerator at 2°C to 8°C, keep it in its original carton, and do not freeze or shake it.
Fact Box
Molecule name | Denosumab |
Therapeutic class | Anti-resorptive agent |
Pharmacological class | RANK ligand (RANKL) inhibitor |
Indications | Multiple myeloma, bone metastases from solid tumours, and giant cell tumour of bone |
References
Disclaimer
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Author Details
Written By
Naina Boruah
MSc Biomedical Science
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 29 Sep 2026 | 05:02 AM (IST)
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