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  3. NP-Free Tablet
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Mecobion NP Tablet

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₹ 23.10/tablet

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Quick summary
Quick Summary

NP-Free Tablet

nortriptyline,pregabalin,methylcobalamin
Written By:Sakshi Anil MoreB. Pharm Reviewed By:Dr. Tejashwin AdigaMBBS

Last updated on 31 Mar 2026 | 09:30 AM (IST)

₹232

MRP: ₹290

(You Save ₹58)

10 TABLET(s) IN A STRIP

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20% OFF
NP-Free Tablet
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4.8 ⭐️ On Google

NP-Free Tablet


Salt Composition

NORTRIPTYLINE,PREGABALIN,METHYLCOBALAMIN

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SYMBION LIFE SCIENCE

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NP-Free Tablet
Preview
We are Rated 4.8 ⭐️ On Google

₹232

MRP: ₹290.00

Inclusive of all taxes

20% Off

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10 Tablet(s) In A Strip

10 Tablet(s) In A Strip

₹ 23.2/Unit

10 TABLET(s) IN A STRIP


Salt Composition

NORTRIPTYLINE,PREGABALIN,METHYLCOBALAMIN

Marketer

SYMBION LIFE SCIENCE


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Mecobion NP Tablet

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0% cheaper

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Introduction to NP-Free Tablet

NP-Free Tablet contains an active component such as Nortriptyline, pregabalin, and methylcobalamin. Nortriptyline is an antidepressant medication that belongs to the class of drugs known as tricyclic antidepressants (TCAs). Pregabalin is an anticonvulsant and antiepileptic medication used to treat neuropathic pain, especially in conditions like diabetic neuropathy, postherpetic neuralgia, and fibromyalgia. Methylcobalamin is a form of vitamin B12, an essential nutrient for the body. It is used as a dietary supplement to treat vitamin B12 deficiency, which can lead to anaemia and nervous system problems. 

Individuals with known hypersensitivity or allergy to nortriptyline, pregabalin, methylcobalamin or other components of these medications should not take them. It is primarily eliminated through the kidneys. Therefore, individuals with severe renal impairment or end-stage renal disease should not use this medication. There is limited data on the safety of NP-Free tablets during pregnancy and breastfeeding. Pregnant or breastfeeding individuals should consult their healthcare provider before using this medication.

Uses of NP-Free Tablet

NP-Free Tablet is used to treat the following:

  • Neuropathic pain

Therapeutic Effects of NP-Free Tablet

These medications prescribed by healthcare professionals in specific cases where the patient's medical condition requires multimodal treatment. For example, some individuals with neuropathic pain may benefit from a combination of nortriptyline and pregabalin as they work through different mechanisms to address pain and may have a synergistic effect. Nortriptyline works by affecting the levels of certain neurotransmitters in the brain, such as serotonin and norepinephrine, which play a role in regulating mood and pain perception. Pregabalin works by reducing the release of certain neurotransmitters in the brain, which helps to decrease pain signals and alleviate anxiety symptoms. Methylcobalamin can be added to support nerve health and potentially enhance the treatment outcomes.

Interaction of NP-Free Tablet with other drugs

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with NP-Free Tablet, reducing effectiveness by causing undesirable side effects.

More Information about NP-Free Tablet

  • Store at room temperature, between 20°C to 25°C (68°F to 77°F).
  • Keep away from moisture, heat, and light.
  • It should not be frozen.
  • Keep away from children and pets.

How to consume NP-Free Tablet

NP-Free Tablet can be administered orally in tablet form. The specific usage instructions may vary depending on the condition being treated, age, and the individual's weight. Oral tablets are typically taken with water, as directed by the healthcare provider. 

Safety Advice for NP-Free Tablet

Breast Feeding-Consult your doctor

Breast Feeding

Consult Your Doctor

The safety of NP-Free Tablet during breastfeeding has not been well studied, and limited information is available regarding its excretion into breast milk. As a result, it is recommended to exercise caution when using it while breastfeeding.

Alcohol-unsafe

Alcohol

Unsafe

NP-Free Tablet with alcohol can increase the risk of certain side effects and adverse reactions. It is generally recommended to avoid or limit alcohol consumption while taking these medications.

Liver-Consult your doctor

Liver

Consult Your Doctor

If you have a liver impairment or concerns about the safety of using NP-Free Tablets, discuss these with your healthcare provider. They can provide personalised guidance and ensure the most appropriate treatment plan for your medical condition.

Lungs-Consult your doctor

Lungs

Consult Your Doctor

Individuals with pre-existing lung conditions must inform their healthcare provider about their medical history before starting any new medication.

Driving-unsafe

Driving

Unsafe

NP-Free Tablet can cause side effects that may impair driving abilities in some individuals. Therefore, caution is advised when operating a vehicle or performing any tasks that require alertness and concentration while taking these medications.

Pregnancy-Consult your doctor

Pregnancy

Consult Your Doctor

The safety of NP-Free Tablet during pregnancy has not been extensively studied, and limited information is available regarding its use in pregnant women. So it is advisable to consult a healthcare provider before using it.

Side Effects of NP-Free Tablet

NP-Free Tablet cause some side effects like all medications, although not everyone will experience them. 

Serious side effects:

  • Allergic reactions (e.g., rash, hives, difficulty breathing)
  • Swelling of the hands, feet, or ankles
  • Unusual bleeding or bruising
  • Mood changes or depression
  • Suicidal thoughts
  • Irregular heartbeat
  • Severe dizziness or fainting

Common side effects:

  • Constipation
  • Dry mouth
  • Headache
  • Feeling sleepy, tired or dizzy
  • Diarrhoea
  • Weight gain
  • Blurred vision

Word of Advice

If you have prescribed NP-Free Tablet for neuropathic pain, follow your healthcare provider's instructions carefully. Monitor for unusual symptoms, such as mood changes and irregular heartbeat. If you experience any unusual or severe side effects while taking these medications, contact your doctor immediately. Pregnant or breastfeeding individuals should inform their obstetrician or healthcare provider before using this combination, as certain medications may not be safe during pregnancy or lactation. Regularly attend follow-up appointments and communicate openly with your healthcare provider about any concerns or questions for a successful and safe diabetes management journey.

FAQs about NP-Free Tablet

Q1.

What is the purpose of the combination of nortriptyline, pregabalin, and methylcobalamin?

This combination may be prescribed for individuals with certain medical conditions that require multimodal treatment. Nortriptyline is an antidepressant that may help with depression and neuropathic pain, while pregabalin is used to treat neuropathic pain and certain anxiety disorders. Methylcobalamin is a form of vitamin B12 that supports nerve health. The combination aims to address pain and neurological symptoms effectively.

Q2.

Are there any specific precautions or side effects associated with NP-Free Tablet

Yes, there may be specific precautions and side effects associated with NP-Free Tablet. Patients should consult their healthcare provider before starting this treatment to discuss individual health concerns, potential drug interactions, and any contraindications.

Q3.

Can I take this combination if I am pregnant or breastfeeding?

Pregnant or breastfeeding individuals should consult their healthcare provider before taking this medication. Some medications may be unsafe during pregnancy or breastfeeding, and alternative treatments may be considered.

Q4.

How should I take NP-Free Tablet?

Follow your doctor's instructions carefully regarding dosage, timing, and any specific recommendations for taking NP-Free Tablet. Never alter the prescribed dosages without consulting your healthcare provider.

Q5.

Is NP-Free Tablet addictive?

NP-Free Tablet has the potential for abuse and dependence, especially in individuals with a history of substance abuse.

Fact Box of NP-Free Tablet

Molecule name: Nortriptyline, Pregabalin, Methylcobalamin

 

 

Therapeutic class: Antidepressant and Anticonvulsive

Pharmacological class: 

1. Nortriptyline: Tricyclic antidepressants

2. Pregabalin: Anticonvulsant

3. Methylcobalamin: Vitamin B12 Supplement

Indications: Neuropathic pain

References

  1. Ram Prabhoo et al., Efficacy and Tolerability of a Fixed Dose Combination of Methylcobalamin and Pregabalin in the Management of Painful Neuropathy, [Revised on 4/11/2012] [Accessed on 19/07/2023], https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503385/
  2. Yasmin U Dongre et al., Sustained-release pregabalin with methylcobalamin in neuropathic pain: an Indian real-life experience [Revised on 19/5/2013] [Accessed on 19/07/2023], https://pubmed.ncbi.nlm.nih.gov/23761981/

Disclaimer

MrMed’s primary intention is to ensure that its consumers get accurate and trustworthy information that is reviewed by experts. The contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.

Did you find this information helpful?

Author Details
Sakshi Anil More

Written By

Sakshi Anil More

B. Pharm


Dr. Tejashwin Adiga

Reviewed By

Dr. Tejashwin Adiga

MBBS


Last updated : 31 Mar 2026 | 09:30 AM (IST)

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