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Endace 40mg Tablet

Prescription Required

Salt Composition : Megestrol


Origin of Medicine : India

MRP: 341.2
Price :290
You Save :51 (15%)

10 Tablet(s) In A Strip

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Introduction to Endace 40mg Tablet

Endace 40mg Tablet contains the active substance Megestrol. It belongs to a category of medications called progestogens and is used to treat certain hormone-dependent cancers, namely breast cancer. It is a synthetic form of the naturally occurring progesterone hormone. It is also indicated to treat unexplained weight loss, cachexia (weakness) and anorexia (loss of appetite) in patients with weak immune systems and cancer. 

Progestogens are used in patients whose disease has progressed with conventional anti-estrogen therapy. Your physician will assess the estrogen status (ER) to ensure that your breast cancer is due to the expression of the estrogen receptor.

Uses of Endace 40mg Tablet

  • Treatment of hormone-dependent cancer (endometrial cancer, breast cancer)
  • Treatment of anorexia, cachexia or unexplained weight loss

Therapeutic Effects of Endace 40mg Tablet

Endace 40mg Tablet exhibits anticancer properties by interacting with steroidal receptors. It suppresses steroid production by the adrenal glands and androgen secretion by the ovaries in postmenopausal women. It also prevents the breakdown of cytokines and stimulates appetite in chronic disease-induced anorexia and cachexia.

Interaction of Endace 40mg Tablet with other drugs

Inform your doctor about any prescribed medicines, over-the-counter medications, nutritional and vitamin supplements and herbal products you are taking or have taken before the treatment. Certain medications may interact with the efficacy of Endace 40 mg tablet.

More Information about Endace 40mg Tablet

Store below 25°C, protected from light and moisture.

How to consume Endace 40mg Tablet

Swallow the tablet whole with water. Your physician will decide the ideal dose for you, depending on your condition.

Safety Advices for Endace 40mg Tablet

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This medicine is unsafe to consume during pregnancy. Inform your physician before starting this treatment if you are pregnant or think you might be pregnant. 

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Breast Feeding


Consult your physician before taking this tablet if you are a breastfeeding mother.

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Inform your physician if you have any lung diseases before taking Endace 40 mg tablet. 

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Inform your physician before starting this treatment if you have liver problems. Your physician will monitor your liver functions regularly.

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It is not known whether it is safe to consume alcohol with Endace 40 mg Tablet. Please consult your doctor.

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Avoid driving or using machinery if you experience side effects.

Side Effects of Endace 40mg Tablet

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.


  • Swelling of the face, lips, tongue
  • Skin rash
  • Breathing difficulty
  • Blood clot in the lungs
  • Heart problems


  • Weight gain and increased appetite
  • Hot flushes
  • High BP
  • High blood sugar levels
  • Rounded face
  • Constipation
  • Swelling of vein
  • Mood changes
  • Hair loss
  • Diarrhea
  • Tiredness and weakness
  • Impotence
  • Passing wind
  • Frequent urination
  • Nausea, vomiting
  • Fluid accumulation
  • Pain

Word of Advice

Inform the doctor if the patient has any history of kidney, liver, or allergic reactions before starting this medication. Kidneys, liver, blood pressure, and blood glucose levels should be monitored while taking this medication. Avoid taking this medication while planning for pregnancy or during pregnancy, as it causes harmful effects on developing babies. This medication should not be stopped without proper advice from the doctor because it can worsen the situation. Inform the doctor immediately if any sign of swelling and pain in the limbs, shortness of breath, chest pain, severe headache, or changes in vision.


Q 1. Does Endace 40mg Tablet cause weight gain?

Yes, it is a common side effect which is caused due to an increase in appetite. It leads to an increase in fat and body mass. If there is excessive weight gain patients are advised to consult the doctor.

Q 2. Is Endace 40mg Tablet safe to use during pregnancy?

No, it is unsafe to use this medication in pregnancy because it causes harmful effects in the developing baby. Patients are asked to avoid this medication if they are planning for pregnancy or during pregnancy.

Q 3. Does Endace 40mg Tablet stop periods?

No, it doesn't stop periods and it can cause excessive bleeding. consult the doctor if there is any excessive bleeding.

Q 4. What are the side effects of the Endace 40mg Tablet?

The common side effects of Endace 40mg Tablet are weight gain, increase in appetite, high blood pressure, constipation, rounded face, mood changes, hair loss, tiredness and weakness, nausea, vomiting, and swelling of the vein.

Q 5. How should I take the Endace 40mg Tablet?

Endace 40mg Tablet should be taken as prescribed by the doctor and it can be taken with or without food, preferably at the same time daily. It is important to take this medicine even when the patient is feeling well and don't stop this medication without the proper advice of the doctor as it will worsen the condition.

Q 6. Can I drive after taking the Endace 40mg Tablet?

It is unsafe to use this medication while driving as it causes dizziness and patients may lack concentration and alertness.

Fact Box of Endace 40mg Tablet

Molecule name: Megestrol

Therapeutic class: Progestins 

Pharmacological class: Anti-Neoplastics


1. Treatment of hormone-dependent cancer (endometrial cancer, breast cancer)

2. Treatment of anorexia, cachexia or unexplained weight loss


  1. Bausch and Lomb UK Ltd., Electronic Medicines Compendium (EMC), [Revised on Sep 2020] [Accessed on 17th Jul 2021],
  2. alniche Life Sciences Pvt Ltd., [Revised on 2021] [Accessed on 19th Jul 2021],
  3. Bines et al., Activity of megestrol acetate in postmenopausal women with advanced breast cancer after nonsteroidal aromatase inhibitor failure: a phase II trial, Annals of Oncology, 2014, 25(4), 831-836,
  4. G.G. Dark, A.R. Abdul Razak, Oncology, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 259-282.


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