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Megarest 40mg Tablet
Last updated on 31 Mar 2026 | 09:29 AM (IST)
₹170
MRP: ₹227
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Introduction to Megarest 40mg Tablet
Megarest 40mg Tablet contains the active substance Megestrol. It belongs to a category of medications called progestogens and is used to treat certain hormone-dependent cancers, namely breast cancer. It is a synthetic form of the naturally occurring progesterone hormone. It is also indicated to treat unexplained weight loss, cachexia (weakness) and anorexia (loss of appetite) in patients with weak immune systems and cancer.
Progestogens are used in patients whose disease has progressed with conventional anti-estrogen therapy. Your physician will assess the estrogen status (ER) to ensure that your breast cancer is due to the expression of the estrogen receptor.
Uses of Megarest 40mg Tablet
- Treatment of hormone-dependent cancer (endometrial cancer, breast cancer)
- Treatment of anorexia, cachexia or unexplained weight loss
Therapeutic Effects of Megarest 40mg Tablet
Megarest 40mg Tablet exhibits anticancer properties by interacting with steroidal receptors. It suppresses steroid production by the adrenal glands and androgen secretion by the ovaries in postmenopausal women. It also prevents the breakdown of cytokines and stimulates appetite in chronic disease-induced anorexia and cachexia
Interaction of Megarest 40mg Tablet with other drugs
Inform your doctor about any prescribed medicines, over-the-counter medications, nutritional and vitamin supplements and herbal products you are taking or have taken before the treatment. Certain medications may interact with the efficacy of Endace 160 mg Tablet.
More Information about Megarest 40mg Tablet
- Store below 25°C, protected from light and moisture.
- Keep out of reach of children
How to consume Megarest 40mg Tablet
Swallow the tablet whole with water. Your physician will decide the ideal dose for you, depending on your condition.
Safety Advice for Megarest 40mg Tablet
Breast Feeding
Consult your physician before taking this tablet if you are a breastfeeding mother.
Alcohol
It is not known whether it is safe to consume alcohol with Megarest 40mg Tablet. Please consult your doctor.
Liver
Inform your physician before starting this treatment if you have liver problems. Your physician will monitor your liver functions regularly.
Lungs
Inform your physician if you have any lung diseases before taking Megarest 40mg Tablet.
Driving
Avoid driving or using machinery if you experience side effects.
Pregnancy
This medicine is unsafe to consume during pregnancy. Inform your physician before starting this treatment if you are pregnant or think you might be pregnant.
Side Effects of Megarest 40mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious:
- Swelling of the face, lips, tongue
- Skin rash
- Breathing difficulty
- Blood clot in the lungs
- Heart problems
Common:
- Weight gain and increased appetite
- Hot flushes
- High BP
- High blood sugar levels
- Rounded face
- Constipation
- Swelling of vein
- Mood changes
- Hair loss
- Diarrhea
- Tiredness and weakness
- Impotence
- Passing wind
- Frequent urination
- Nausea, vomiting
- Fluid accumulation
- Pain
Word of Advice
Inform the doctor if the patient has any history of kidney, liver, or allergic reactions before starting this medication. Kidneys, liver, blood pressure, and blood glucose levels should be monitored while taking this medication and avoid taking this medication while planning for pregnancy or during pregnancy as it causes harmful effects on developing babies. This medication should not be stopped without proper advice from the doctor because it can worsen the situation. Inform the doctor immediately if any sign of swelling and pain in the limbs, shortness of breath, chest pain, severe headache, or changes in vision.
FAQs about Megarest 40mg Tablet
Q1.
Does Megarest 40mg Tablet cause weight gain?
Yes, it is a common side effect which is caused due to an increase in appetite. It leads to an increase in fat and body mass. If there is excessive weight gain patients are advised to consult the doctor.
Q2.
Is Megarest 40mg Tablet safe to use during pregnancy?
No, it is unsafe to use this medication in pregnancy because it causes harmful effects in the developing baby. Patients are asked to avoid this medication if they are planning for pregnancy or during pregnancy.
Q3.
Does Megarest 40mg Tablet stop periods?
No, it doesn't stop periods and it can cause excessive bleeding. consult the doctor if there is any excessive bleeding.
Q4.
What are the side effects of the Megarest 40mg Tablet?
The common side effects of Megarest 40mg Tablet are weight gain, increase in appetite, high blood pressure, constipation, rounded face, mood changes, hair loss, tiredness and weakness, nausea, vomiting, swelling of the vein.
Q5.
How should I take the Megarest 40mg Tablet?
Megarest 40mg Tablet should be taken as prescribed by the doctor and it can be taken with or without food, preferably at the same time daily. It is important to take this medicine even when the patient is feeling well and don't stop this medication without the proper advice of the doctor as it will worsen the condition.
Fact Box of Megarest 40mg Tablet
Molecule name: Megestrol
| Therapeutic class: Progestins |
| Pharmacological class: Anti-neoplastics | Indications: 1. Treatment of hormone-dependent cancer (endometrial cancer, breast cancer) 2. Treatment of anorexia, cachexia or unexplained weight loss |
References
- Bausch and Lomb UK Ltd., Electronic Medicines Compendium (EMC), [Revised on Sep 2020] [Accessed on 17th Jul 2021], https://www.medicines.org.uk/emc/files/pil.11135.pdf
- alniche Life Sciences Pvt Ltd., [Revised on 2021] [Accessed on 19th Jul 2021], https://www.alniche.com/product/megahenz/
- Bines et al., Activity of megestrol acetate in postmenopausal women with advanced breast cancer after nonsteroidal aromatase inhibitor failure: a phase II trial, Annals of Oncology, 2014, 25(4), 831-836, https://www.annalsofoncology.org/action/showPdf?pii=S0923-7534%2819%2936501-9
- G.G. Dark, A.R. Abdul Razak, Oncology, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 259-282.
Disclaimer
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Author Details
Written By
Dr. Vijayalakshmi N.
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:29 AM (IST)
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