Megacet 40mg Tablet

• Treatment of hormone-dependent cancer (endometrial cancer, breast cancer)
• Treatment of anorexia, cachexia or unexplained weight loss

Megacet 40mg Tablet, containing megestrol, is a synthetic progestin used primarily for managing hormone-sensitive cancers like breast and endometrial cancer, where it alters hormonal pathways to slow cancer cell growth. It is also prescribed to treat cancer-related cachexia and anorexia, helping improve appetite and promote weight gain in patients with severe weight loss due to advanced cancer or HIV/AIDS. Additionally, it exhibits anti-inflammatory and immune-modulating properties, making it beneficial in certain chronic conditions. However, caution is required in individuals with diabetes, thromboembolic disorders, or adrenal insufficiency, as it can affect metabolic and hormonal balance, necessitating close medical supervision.

Megacet 40mg Tablet, containing megestrol, may interact with various medications, affecting their efficacy and safety. It can reduce the effectiveness of antidiabetic drugs, potentially leading to increased blood sugar levels, requiring dose adjustments in diabetic patients. Concomitant use with anticoagulants like warfarin may alter blood clotting, necessitating close monitoring of INR levels to prevent bleeding or clotting risks. Corticosteroids and immunosuppressants may experience altered metabolism when taken alongside megestrol, which could impact their therapeutic effects. Additionally, drugs that induce hepatic enzymes, such as rifampin and phenytoin, may lower megestrol levels, reducing its effectiveness, whereas CYP3A4 inhibitors like ketoconazole might increase its concentration, leading to potential side effects. Patients should inform their healthcare provider about all ongoing medications to avoid adverse interactions and ensure safe usage.

• Store below 25°C.
• Protect from light and moisture.
• Keep away from children and pets

Megacet 40mg Tablet should be taken exactly as prescribed by a healthcare professional. It is usually taken orally with or without food, but taking it at the same time each day helps maintain consistent blood levels. The tablet should be swallowed whole with a glass of water and should not be crushed, broken, or chewed. The dosage and duration depend on the patient's medical condition and response to treatment. It is important not to stop or adjust the dose without consulting a doctor. If a dose is missed, it should be taken as soon as remembered, but if it is almost time for the next dose, the missed dose should be skipped to avoid double dosing. Always follow your doctor’s instructions and read the patient information leaflet for any specific guidelines related to your condition.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Swelling of the face, lips, tongue
• Skin rash
• Breathing difficulty
• Blood clot in the lungs
• Heart problems

Common:

• Weight gain and increased appetite
• Hot flushes
• High BP
• High blood sugar levels
• Rounded face
• Constipation
• Swelling of vein
• Mood changes
• Hair loss
• Diarrhea
• Tiredness and weakness
• Impotence
• Passing wind
• Frequent urination
• Nausea, vomiting
• Fluid accumulation
• Pain

Inform the doctor if the patient has any history of kidney, liver, allergic reactions before starting this medication. Kidneys, liver, blood pressure and blood glucose levels should be monitored while taking this medication and avoid taking this medication while planning for pregnancy or during pregnancy as it causes harmful effects on developing babies. This medication should not be stopped without proper advice from the doctor because it can worsen the situation. Inform the doctor immediately if there are any signs of swelling and pain in the limbs, shortness of breath, chest pain, severe headache, or changes in vision.