Mashema 5mg Cartridge 1ml may be prescribed for:

• Long-term weight management: It may be used in adults with obesity and in adults who are overweight with a weight-related medical condition. It is also used for long-term weight management in adolescents aged 12 years and older with obesity.

• Type 2 diabetes mellitus: It may be used to help improve blood sugar control in people with Type 2 diabetes mellitus.

• Cardiovascular risk reduction: It may be prescribed alongside a reduced-calorie diet and increased physical activity to help lower the risk of major cardiovascular events, such as heart attack, stroke, or cardiovascular-related death, in adults with established heart disease who are overweight or obese.

• Non-alcoholic steatohepatitis (NASH): It may be used in adults with non-cirrhotic NASH and moderate to advanced liver fibrosis.

Mashema should be used along with suitable dietary changes and regular physical activity. The dose is selected and adjusted by the doctor based on the individual's condition and treatment plan.

Semaglutide works similarly to the natural hormone GLP-1, which helps regulate blood sugar, appetite, and digestion. It activates GLP-1 receptors and enhances glucose-dependent insulin secretion while reducing glucagon release.

It also slows gastric emptying and increases feelings of fullness. These effects can reduce hunger and food intake and may support weight management while helping improve blood sugar control.

Tell your doctor about all medicines, supplements, and herbal products you are taking before starting Mashema 5mg Cartridge 1ml.

• Insulin and sulfonylureas: Semaglutide may increase the risk of low blood sugar when used with insulin or medicines such as sulfonylureas. Your doctor may adjust the dose of these medicines.

• Medicines taken by mouth: Semaglutide slows gastric emptying and may affect the absorption of some oral medicines.

• Other Semaglutide-containing medicines: Do not combine Mashema with another Semaglutide-containing medicine unless advised by your doctor.

• Other GLP-1 receptor agonists: Tell your doctor if you are using another GLP-1 receptor agonist before starting Mashema.

• Store Mashema 5mg Cartridge 1ml in a refrigerator at 2°C to 8°C.

• Do not freeze.

• Protect the medicine from excessive heat and sunlight.

• Keep out of reach of children.

• After first use, store the assembled pen for up to 56 days at a controlled room temperature of 15°C to 30°C or in a refrigerator at 2°C to 8°C.

• Follow the storage instructions provided with the product.

Mashema 5mg Cartridge 1ml is given once weekly as a subcutaneous injection, exactly as prescribed by your doctor. It can be injected into the abdomen, thigh, or upper arm. Rotate the injection site when possible.

Mashema is supplied as a multidose cartridge that needs to be installed in the reusable Mashema customised pen before use. The pack contains one 1 mL cartridge and five needles. Your doctor, healthcare professional, or caregiver should train you on how to use the pen and cartridge correctly before you administer it at home.

Use Mashema on the same day each week as advised by your doctor. Follow the prescribed dose and do not change the dose or frequency without medical advice.

Common side effects of Mashema 5mg Cartridge 1ml may include:

• Indigestion

• Dizziness

• Burping

• Low blood sugar (hypoglycaemia)

• Gastroenteritis

• Nasopharyngitis

• Constipation

• Nausea

• Vomiting

• Diarrhoea

• Stomach pain

These effects may occur when treatment is started and may improve as the body adjusts to the medicine.

Seek medical attention if you develop severe or persistent abdominal pain, particularly if it is accompanied by nausea or vomiting. Inform your doctor if you experience symptoms that concern you or do not improve.

• Administer Mashema 5mg Cartridge 1ml once weekly on the day prescribed by your doctor.

• Use the cartridge only with the reusable Mashema customised pen.

• Follow the training provided by your doctor or healthcare professional before using the cartridge at home.

• Rotate injection sites between the abdomen, thigh, and upper arm.

• Monitor your blood sugar regularly if advised by your doctor, particularly if you also use insulin or a sulfonylurea.

• Eat small, well-balanced meals and avoid greasy or high-fat foods if they worsen nausea or stomach discomfort.

• Stay well hydrated, particularly if you experience nausea, vomiting, or diarrhoea.

• Be alert for severe abdominal pain or other symptoms that may indicate pancreatitis and seek medical attention if they occur.

• Tell your healthcare providers that you are using Mashema before any surgical procedure, as the medicine may slow stomach emptying and increase the risk of aspiration.