Mashema 15mg Cartridge 3ml is used:

• To improve blood sugar control in adults with type 2 diabetes mellitus, along with diet and exercise.

• For chronic weight management in eligible adults with obesity or overweight with weight-related health conditions, along with a reduced-calorie diet and increased physical activity.

Mashema 15mg Cartridge 3ml contains Semaglutide, a GLP-1 receptor agonist. It acts like a natural hormone involved in blood sugar and appetite regulation.

It helps the body release insulin when blood sugar is elevated and reduces glucagon release. It also slows stomach emptying and increases feelings of fullness, which can help reduce food intake and support weight management.

Tell your doctor about all prescription medicines, over-the-counter medicines, vitamins and herbal supplements you take.

• Insulin and sulfonylureas: Using Semaglutide with insulin or sulfonylureas can increase the risk of low blood sugar. Your doctor may adjust the dose of these medicines.

• Oral medicines: Semaglutide slows stomach emptying and may affect the absorption of some medicines taken by mouth.

• Other Semaglutide-containing medicines or GLP-1 receptor agonists: Do not use Mashema with another Semaglutide-containing medicine or another GLP-1 receptor agonist unless specifically advised by your doctor.

• Store Mashema 15mg Cartridge 3ml according to the storage instructions provided with the product.

• Keep the cartridge refrigerated at 2°C to 8°C before use unless the product instructions state otherwise.

• Do not freeze.

• Protect it from excessive heat and light.

• Keep it out of the sight and reach of children.

Use Mashema 15mg Cartridge 3ml exactly as prescribed by your doctor.

It is administered once weekly by subcutaneous injection using the compatible reusable pen. The injection is generally given into the abdomen, thigh or upper arm. Do not inject it into a vein or muscle.

The dose is usually started low and increased gradually to reduce gastrointestinal side effects. Do not change the dose or injection schedule on your own.

Use a new needle for each injection and do not share the pen or needles with another person.

Common side effects:

• Nausea

• Vomiting

• Diarrhoea

• Constipation

• Abdominal pain

• Headache

• Indigestion

• Dizziness

• Abdominal discomfort or bloating

These effects are more common when the dose is increased and may improve as the body adjusts to treatment.

Serious side effects:

• Severe or persistent abdominal pain, which may indicate pancreatitis

• Severe allergic reactions

• Severe or persistent vomiting or diarrhoea causing dehydration

• Gallbladder problems

• Low blood sugar when used with insulin or sulfonylureas

• Changes in vision, particularly in people with diabetic retinopathy

• Symptoms of thyroid tumours such as a neck lump, persistent hoarseness or difficulty swallowing

Seek medical attention if you develop severe or persistent symptoms. Semaglutide is contraindicated in people with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2.

• Use Mashema once weekly exactly as prescribed.

• Do not increase the dose without your doctor's advice.

• Follow the instructions supplied with the reusable pen and cartridge.

• Use a new needle for every injection.

• Do not share the pen or needles with another person.

• Eat smaller meals if nausea or early fullness occurs.

• Drink enough fluids if vomiting or diarrhoea occurs.

• Tell your doctor about any planned surgery or procedure requiring anaesthesia or deep sedation.

• Inform your doctor if you have a history of pancreatitis, gallbladder disease, diabetic retinopathy or severe gastrointestinal problems.