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Palborest 75mg Tablet
Last updated on 31 Mar 2026 | 09:30 AM (IST)
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Introduction to Palborest 75mg Tablet
Palborest 75mg Tablet is a targeted therapy containing the active constituent Palbociclib. It belongs to the group of anticancer medications known as cyclin-dependent kinase inhibitors. It is used in treating hormone receptor-positive, human epidermal growth factor 2 negative advanced or metastatic (has spread to other parts of the body) breast cancer. Cancer is a condition in which cells multiply in an uncontrolled and abnormal manner. It is given in combination with certain other anticancer medications.
The common side effects that are likely to associate with Palborest 75mg Tablet are nausea, vomiting, diarrhea, tiredness, hair loss, dry skin, rash, infections, nose bleed, decreased appetite, low blood cell counts, swelling of lips and mouth, changes in taste, dry eye, blurred vision, and increased tearing. Inform your doctor if any of these side effects disturb or persist in you.
Inform your healthcare provider if you are allergic to Palborest 75mg Tablet and its ingredients. Before taking this medicine, it is vital to inform your doctor if you have any signs of infections (fever, chills, or sore throat), liver disorders, kidney disorders, or intolerance to some sugars. Consult your physician immediately if you experience symptoms such as dry cough, chest pain, difficulty breathing, as it could indicate lung inflammation.
Make sure you inform your physician of all the medicines, including supplements and herbal medicines, you are taking before you start treatment with this medication. Use effective birth control during the treatment and at least three weeks after the last dose. It is not recommended for adolescents and children under 18 years of age.
Uses of Palborest 75mg Tablet
Treatment of hormone receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative advanced or metastatic breast cancer.
Therapeutic Effects of Palborest 75mg Tablet
Palborest 75mg Tablet works by blocking the protein called cyclin-dependent kinases 4 and 6, which are vital for the division and growth of cells. By blocking these proteins, this medication slows the growth and prevents the cancer cells from spreading.
Interaction of Palborest 75mg Tablet with other drugs
Inform your doctor about all medications including prescribed, over-the-counter, nutritional or vitamin supplements and herbal products that you are taking or have taken before the treatment. Concurrent use of Palborest 75mg Tablet with CYP3A4 inhibitors such as fentanyl has reported increased fentanyl toxicity. certain medications may interact with the effectiveness of this drug.
More Information about Palborest 75mg Tablet
- Keep Palborest 75mg Tablet out of sight and reach of children.
- Store at 20°C to 25°C.
How to consume Palborest 75mg Tablet
Take Palborest 75mg Tablet exactly as prescribed by your doctor. Take this medication once a day at the same time with food. Swallow this capsule as a whole with a glass of water. Avoid crushing, breaking, or chewing the capsule.
Safety Advice for Palborest 75mg Tablet
Breast Feeding
It is not recommended to take Palborest 75mg Tablet while breastfeeding as it is not known whether it passes into the breast milk.
Alcohol
You need to tell your physician if you have any kidney disorders before taking Palborest 75mg Tablet, as this medication should be used with caution in kidney disorder patients.
Liver
Inform your physician if you have any liver disorders before taking Palborest 75mg Tablet, as it should be used with caution in liver disorder patients.
Lungs
Inform your physician if you have any lung disorders before taking Palborest 75mg Tablet, as it should be used with caution in liver disorder patients.
Driving
It is unknown whether it is safe to drink alcohol while taking Palborest 75mg Tablet. Check with your doctor for advice.
Pregnancy
It is not recommended to take Palborest 75mg Tablet during pregnancy as it can harm the unborn baby. Women with childbearing potential should use effective contraceptives during treatment and for at least three weeks after treatment.
Side Effects of Palborest 75mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious:
- Blood disorder (fever, chills, shortness of breath, weakness, bleeding, or bruising)
- Lung inflammation (chest pain, dry cough, or difficulty breathing)
Common:
- Tiredness
- Hair loss
- Dry skin, rash
- Infections
- Low blood cell counts
- Decreased of appetite
- Nausea, vomiting
- Diarrhea
- Swelling of lips and mouth
- Changes in taste
- Nose bleed
- Dry eye, blurred vision, increased tearing
Word of Advice
During Palborest 75mg Tablet treatment, it is advised to avoid grapefruit and its juices and preparations containing St. John's wort. It is recommended to use effective birth control while receiving treatment as well as for at least three weeks after the final dose for females and at least fourteen weeks after the final dose for males.
This medication may reduce fertility, so discuss with the physician if you have any concerns. Your doctor may recommend regular blood tests to determine whether Palborest 75mg Tablet affects your blood cells.
FAQs about Palborest 75mg Tablet
Q1.
Is Palborest 75mg Tablet targeted therapy?
Yes, Palborest 75mg Tablet is a targeted therapy. This medication belongs to the class of cyclin-dependent kinase inhibitors.
Q2.
Does Palborest 75mg Tablet affect blood cell count?
Palborest 75mg Tablet might reduce the number of white blood cells and weaken the immune system. It could lead to an increase in the risk of infections. Regular blood tests while taking Palborest 75mg Tablet are advised.
Q3.
Does Palborest 75mg Tablet affect fertility?
Yes, Palborest 75mg Tablet may reduce fertility in men. It may affect your ability to become a father and a child. Hence, men should consider sperm preservation before taking this medication.
Fact Box of Palborest 75mg Tablet
Molecule name | Palbociclib |
Therapeutic class | Cyclin-dependent kinase inhibitor |
Pharmacological class | Anticancer agents |
Indications | HR-positive, HER2-negative advanced or metastatic breast cancer |
References
- Pfizer Limited, Electronic medicines compendium (emc), [Revised on June 2021] [ Accessed on 26 Nov 2022], https://www.medicines.org.uk/emc/files/pil.4449.pdf
- Pfizer Labs, US Food and Drug Administration, [Revised on March 2017] [ Accessed on 26 Nov 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207103s004lbl.pdf
- Neha S Mangini et al; Palborest 75mg Tablet: A Novel Cyclin-Dependent Kinase Inhibitor for Hormone Receptor-Positive Advanced Breast Cancer; The Annals of Pharmacotherapy; Published on Nov 2015; Accessed on 26/11/2022; https://pubmed.ncbi.nlm.nih.gov/26324355/
- Palbace; Pfizer; Revised on Oct 2021; Accessed on 26/11/2022; https://labeling.pfizer.com/ShowLabeling.aspx?id=14029
Disclaimer
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Author Details
Written By
Dr. Arwa Aliakber
B. Pharm
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:30 AM (IST)
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