Rybelsus 3mg Tablet is used for:

• Starting treatment for type 2 diabetes mellitus: It is used as the initial strength when beginning treatment with oral Semaglutide.

• Type 2 diabetes mellitus: Rybelsus is used to improve blood sugar control in adults with type 2 diabetes, along with diet and exercise.

The 3mg strength is used for treatment initiation and is not intended to provide full glycaemic control. After the initial treatment period, the dose is generally increased to 7mg as directed by the doctor.

Rybelsus is not indicated for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis.

Rybelsus 3mg Tablet contains Semaglutide, which acts like GLP-1, a natural hormone involved in blood sugar regulation.

It helps the pancreas release insulin when blood glucose levels are high and reduces the release of glucagon, a hormone that raises blood glucose. Semaglutide also slows stomach emptying and can reduce appetite.

These effects form the basis of Semaglutide's blood glucose-lowering action in people with type 2 diabetes.

Tell your doctor about all prescription medicines, over-the-counter medicines, vitamins, supplements and herbal products you take.

• Insulin and sulfonylureas: Using Rybelsus with insulin or a sulfonylurea can increase the risk of low blood sugar. Your doctor may adjust the dose of these medicines.

• Other oral medicines: Rybelsus can delay stomach emptying and may affect the absorption of medicines taken by mouth. Other oral medicines should generally be taken at least 30 minutes after Rybelsus.

• Levothyroxine: Semaglutide may increase exposure to levothyroxine. Your doctor may monitor thyroid-related parameters if both medicines are used together.

• Warfarin and other coumarin medicines: Closer monitoring of blood clotting may be needed when Semaglutide is started in people taking warfarin or similar medicines.

• Other Semaglutide-containing medicines or GLP-1 receptor agonists: Do not use Rybelsus together with another Semaglutide-containing medicine or GLP-1 receptor agonist unless specifically prescribed by your doctor.

• Store Rybelsus 3mg Tablet in its original blister packaging to protect it from light and moisture.

• Store below 30°C.

• Keep the tablets in a dry place.

• Keep Rybelsus 3mg Tablet out of the sight and reach of children.

• Do not use the tablets after the expiry date printed on the packaging.

Take Rybelsus 3mg Tablet exactly as prescribed by your doctor.

The 3mg strength is usually taken once daily for one month when starting treatment with oral Semaglutide. It is used as an initiation dose to help the body adjust to the medicine and is not intended to provide full glycaemic control.

Take Rybelsus after an overnight fasting period of at least 8 hours. Swallow the tablet whole with a small amount of plain water, up to half a glass (120 mL). Do not split, crush or chew the tablet.

After taking Rybelsus, wait at least 30 minutes before eating, drinking or taking any other oral medicine. Taking food, other drinks or oral medicines sooner can reduce the absorption of Semaglutide.

After one month of treatment with 3mg, your doctor will generally increase the dose to 7mg. Do not increase the dose yourself.

If you miss a dose, skip it and take your next dose on the following day as usual. Do not take two tablets to make up for a missed dose.

Common side effects of Rybelsus 3mg Tablet may include:

• Nausea

• Diarrhoea

• Vomiting

• Abdominal pain

• Constipation

• Decreased appetite

• Indigestion

• Headache

• Dizziness

Nausea, diarrhoea and vomiting can occur when treatment is started. The 3mg strength is used during initiation partly to allow the body to adjust to Semaglutide before the dose is increased.

Serious side effects

Seek medical attention if you develop:

• Severe or persistent abdominal pain, particularly if it spreads to the back, which may indicate pancreatitis.

• Severe allergic reactions such as swelling of the face, lips, tongue or throat or difficulty breathing.

• Persistent vomiting or diarrhoea that may cause dehydration and affect kidney function.

• Severe abdominal pain, fever or yellowing of the skin or eyes, which may indicate gallbladder disease.

• New or worsening vision changes, particularly if you have diabetic retinopathy.

• Symptoms of low blood sugar, especially when Rybelsus is used with insulin or a sulfonylurea.

• Take Rybelsus 3mg Tablet exactly as prescribed during the initial treatment period.

• Remember that 3mg is the starting strength and is not intended to provide full blood sugar control.

• Take the tablet on an empty stomach with only a small amount of plain water.

• Wait at least 30 minutes before eating, drinking or taking other oral medicines.

• Swallow the tablet whole. Do not crush, chew or split it.

• Do not increase the dose to 7mg before completing the prescribed initiation period unless your doctor specifically advises otherwise.

• Tell your doctor if you have a history of pancreatitis, diabetic retinopathy or severe stomach problems.

• Drink enough fluids, particularly if you develop vomiting or diarrhoea.

• Tell your healthcare team that you take Rybelsus before surgery or a procedure involving general anaesthesia or deep sedation.

• If you use insulin or a sulfonylurea, follow your doctor's advice about blood glucose monitoring and dose adjustments.

• Do not stop Rybelsus or change the dose without speaking to your doctor.