SALREVERSE 5ML INJECTION

Introduction:

Salreverse 5ml Injection consist of the active ingredients Glycopyrrolate and Neostigmine Methylsulphate. It is used to counter the effects of non-depolarising muscle relaxants prescribed during surgical procedures. A neuromuscular blockade occurs after surgery and moving the patient to the recovery room. An unsuspected neuromuscular block could result in low ventilation, low oxygen levels in tissues and absence of breathing.

Uses of Salreverse 5ml Injection:

• Reversal of muscle relaxation

How Salreverse 5ml Injection works:

Neostigmine inhibits the enzyme acetylcholinesterase to increase the availability of acetylcholine at the motor endplate. This has an antagonizing effect on the non-depolarising nerve and muscular blockade. Glycopyrrolate counteracts the undesirable effects caused by Neostigmine by blocking the action of acetylcholine present in nerves and smooth muscles. This combination reverses the muscle relaxation produced by medications that relax muscles.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Store below 25˚C, protected from light. Do not freeze.

References:

1. Martindale Pharmaceuticals Ltd, Electronic Medicines Compendium (EMC), [Revised on Oct 2018] [Accessed on 22nd Jun 2021], https://www.medicines.org.uk/emc/files/pil.3390.pdf
2. Marieke Kruidering-Hall, Lundy Campbell, Skeletal Muscle Relaxants, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 474-491.
3. SteriMax Inc., [Revised on 9th Mar 2018] [Accessed on 22nd Jun 2021], https://pdf.hres.ca/dpd_pm/00044183.PDF

How to use Salreverse 5ml Injection:

Use as directed by the anaesthesiologist. Discard unused solution after use.

Safety Advice:

Pregnancy:

Inform your physician before starting this treatment if you are pregnant or think you might be pregnant. Your physician will determine the suitability and safe use of this medicine.

Breastfeeding: 

Consult your physician for advice before this treatment if you are breastfeeding or planning to breastfeed your baby.

Liver:

Inform your physician before starting this treatment if you have liver diseases. Your physician will monitor your liver functions regularly.

Kidney:

Inform your physician before starting this treatment if you have kidney diseases. Your physician will monitor your kidney functions regularly.

Driving: 

This medicine causes blurred vision and other effects that could hinder driving. Avoid driving or using machinery unless your physician approves.

Others:

• Inform your physician if you recently experienced a heart attack.
• Inform your physician before starting this treatment if you have problems in your heart, thyroid, lungs, stomach or intestine.
• Talk to your physician if you have myasthenia gravis or epilepsy.
• Inform your physician if you experience allergic reactions to Glycopyrronium bromide, Neostigmine metilsulphate or other ingredients.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Swelling of face, lips, throat
• Difficulty breathing and swallowing
• Itching and rashes
• Angioedema

Common:

• Dry mouth
• Difficulty passing urine
• Blurred vision
• Lack of sweating
• Slow or irregular heartbeat
• Too much saliva
• Wheezing
• Nausea, vomiting, stomach cramps
• Diarrhea
• Low BP
• Intolerance to light
• Weakness
• Increased secretions from lungs and stomach
• Confusion
• Glaucoma