Semasize 0.5 mg may be used for:

• Management of type 2 diabetes mellitus along with diet and exercise

• Management of obesity as an adjunct to diet and exercise

The doctor decides the appropriate indication, dose and duration of treatment based on your medical condition.

Semasize 0.5 mg contains semaglutide, which mimics the action of the naturally occurring hormone GLP-1. It stimulates insulin release when blood glucose levels are elevated and reduces the release of glucagon, a hormone that raises blood glucose.

Semaglutide also slows the movement of food through the stomach and can reduce appetite. These effects help improve blood glucose control and support weight reduction when used along with appropriate diet and exercise.

Tell your doctor about all medicines you take before starting Semasize 0.5 mg.

• Insulin or sulfonylureas: Using semaglutide with these medicines can increase the risk of low blood sugar. Your doctor may adjust their dose.

• Oral medicines: Semaglutide can delay gastric emptying and may affect the rate at which some oral medicines are absorbed.

• Warfarin or other coumarin medicines: More frequent monitoring of INR may be required when semaglutide treatment is started.

• Other semaglutide-containing medicines or GLP-1 receptor agonists: These should not be used together unless specifically directed by your doctor.

• Store Semasize 0.5 mg in a refrigerator at 2°C to 8°C.

• Do not freeze the medicine.

• Keep it out of reach of children.

• Keep the prefilled syringe in its original packaging and protect it from light.

• Use the syringe only as instructed by your doctor.

• Semasize 0.5 mg is given as an injection under the skin (subcutaneous injection).

• It is generally administered once a week, on the same day each week, as directed by your doctor.

• It can be injected into the abdomen, thigh or upper arm. Avoid injecting into a vein or muscle.

• The prefilled syringe is single-use. Do not reuse or share it with another person.

• Use the dose prescribed by your doctor. Do not change the dose or frequency on your own.

• The pack contains one prefilled syringe and one alcohol swab.

Semasize 0.5 mg may cause gastrointestinal side effects, particularly when treatment is started or the dose is increased.

Common side effects

• Nausea

• Vomiting

• Diarrhoea

• Constipation

• Abdominal pain

• Indigestion

• Decreased appetite

• Headache

• Dizziness

Serious side effects

Contact your doctor promptly if you develop severe or persistent symptoms such as:

• Severe or persistent abdominal pain, which may indicate pancreatitis

• Severe vomiting or diarrhoea with signs of dehydration

• Symptoms of very low blood sugar, particularly when used with insulin or sulfonylureas

• Sudden changes in vision

• Symptoms of a serious allergic reaction such as swelling of the face or throat or difficulty breathing

• Use Semasize exactly as prescribed and do not change your dose without medical advice.

• Try to use your injection on the same day each week.

• Rotate injection sites between the abdomen, thigh and upper arm.

• Do not inject into a vein or muscle.

• Do not reuse or share the prefilled syringe.

• Drink enough fluids, particularly if you experience vomiting or diarrhoea.

• Tell your doctor if you are taking insulin or a sulfonylurea because your risk of low blood sugar may be higher.

• Inform your doctor about all prescription medicines, over-the-counter medicines and supplements you take.

• Tell your doctor if you have a history of pancreatitis, gallbladder problems, severe stomach-emptying problems or diabetic eye disease.

• If you are planning a pregnancy, discuss stopping Semasize with your doctor well in advance.