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Septagan 450mg Tablet
Last updated on 31 Mar 2026 | 09:30 AM (IST)
₹672
MRP: ₹841
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Introduction to Septagan 450mg Tablet
Septagan 450mg tablet contains an active component as Valganciclovir. It belongs to the medication group known as Antiviral (Non-HIV) drugs. After entering the body, Valganciclovir is changed into ganciclovir, which combats viral infections. It is used to treat adult patients with acquired immune deficiency syndrome (AIDS) for cytomegalovirus (CMV) infections of the retina. A cytomegalovirus infection frequently results in blindness and visual impairments. Furthermore, it prevents Cytomegalovirus (CMV) infections in recipients of organ transplants like kidney and heart from adults and children who have the virus.
It is not recommended to use Septagan 450mg tablet in individuals who have a known hypersensitivity or allergic reaction to the medication or any of its components. The safety and effectiveness of Septagan 450mg tablet for the treatment of CMV infection in non-immunocompromised adults, as well as for congenital or neonatal CMV illness, have not been studied hence it is not recommended. Inform your physician if you are pregnant or planning to get pregnant. It is not advised to nurse a child while taking Septagan 450mg tablet as it may cause fetal harm.
Females and males of reproductive potential should be recommended to use effective contraception during therapy and for at least 30 days and 90 days after treatment with Septagan 450mg tablet respectively due to the drug's potential for mutagenic and teratogenic effects. Your physician could advise using a barrier form of birth control, like a condom or diaphragm. Tell your doctor if you have ever had radiation therapy, hemodialysis (a procedure that removes water and waste from the blood), or other renal disorders. A dosage adjustment of Septagan 450mg tablet tablet will be given if you have kidney conditions. Your doctor may regularly take the blood test to monitor the blood count while taking the tablet. It is advised to inform your doctor about all the medicines you are taking including herbal, vitamin supplements and over the counter medicines before starting the treatment.
Uses of Septagan 450mg Tablet
- Treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) in adults
- Prevention of CMV disease in adults and children receiving kidney, heart transplant
Therapeutic Effects of Septagan 450mg Tablet
After oral administration, Septagan 450mg tablet is rapidly converted to ganciclovir by intestinal and hepatic esterases. Ganciclovir is the active form responsible for inhibiting viral replication. Ganciclovir inhibits the synthesis of viral DNA, stopping the cytomegalovirus from replicating. This inhibitory action helps stop the virus from spreading throughout the body by lowering the viral load in infected cells. Ganciclovir is selectively harmful to cytomegalovirus-infected cells due to preferential phosphorylation by viral kinases. This targeted approach primarily targets infected cells while reducing harm to healthy cells.
Interaction of Septagan 450mg Tablet with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Septagan 450mg tablet, reducing effectiveness by causing undesirable side effects.
More Information about Septagan 450mg Tablet
- Store at room temperature, between 15°C to 30°C.
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Septagan 450mg Tablet
Take the Septagan 450mg tablet tablet as advised by your physician. Swallow the tablets whole and intact. This tablet should be taken with food. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the medicine if your doctor advises you to stop. It is important to follow the healthcare professional's instructions regarding the administration technique and schedule.
Safety Advice for Septagan 450mg Tablet
Breast Feeding
It is not recommended to use Septagan 450mg tablet as it is secreted in breast milk, thus there is a risk of exposing the nursing newborn to the medication. A healthcare professional should be consulted before deciding whether to breastfeed while taking Septagan 450mg tablet.
Alcohol
Septagan 450mg tablet is metabolized largely in the liver, and alcohol may worsen the liver's metabolic processes. Excessive consumption of alcohol can damage the liver and raise the risk of liver damage with Septagan 450mg tablet, particularly in people with pre-existing liver disorders.
Liver
Septagan 450mg tablet should be used with caution in people who have liver illness or poor liver function. It is crucial to closely monitor liver function and clinical state. It is advised to consult a healthcare provider if you have any concerns on liver health.
Lungs
It is unknown whether Septagan 450mg tablet is safe to administer in patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
Driving
It is not advised to operate machinery or drive while using Septagan 450mg tablet tablets because they may cause drowsiness, trembling, changes in vision, etc. For more information, please consult your doctor.
Pregnancy
Septagan 450mg tablet is generally not recommended for use during pregnancy unless your doctor recommends taking it. If pregnancy is planned or suspected while using this medication, it is important to inform the healthcare professional promptly. Use effective contraception to avoid pregnancy.
Side Effects of Septagan 450mg Tablet
Septagan 450mg tablet causes some side effects like all medications, although not everyone will experience them.
Serious:
- Anaphylactic shock (sudden swelling of the throat, face, lips, hand, ankles, difficulty swallowing, itchy skin rash)
- Low blood counts
- Blood infection
- Urinary tract infection
- Upper respiratory tract infections
Common:
- Diarrhoea
- Pyrexia
- Nausea
- Tremor
- Headache
- Insomnia
- Vomiting
Word of Advice
It is important to use Septagan 450mg tablet with caution and adhere to the following precautions to ensure its safe and effective use. First, always use under the supervision and guidance of a healthcare professional who can monitor your progress and make necessary adjustments to your treatment plan. Inform your healthcare professional about any existing medical conditions, including liver impairment, kidney impairments, lung conditions, or pregnancy or breastfeeding, as it may have specific considerations in these cases. Adhere to the prescribed dosage and administration instructions, and do not adjust the dose without consulting your healthcare professional. Even if you feel better before finishing the prescribed amount of Septagan 450mg tablet, make sure to finish the complete course of treatment. Early treatment termination may result in insufficient viral clearance and possible recurrence. It is advised to stay hydrated and maintain kidney function by drinking lots of fluids. It's critical to drink enough water to wash out the drug and lower the possibility of kidney-related adverse effects. When taking Septagan 450mg tablet, watch out for any possible adverse effects, such as nausea, vomiting, diarrhea, dizziness, or visual abnormalities. As soon as you notice any strange symptoms, let your healthcare professional know. To lower your chance of catching other infections, stay away from those who are currently infected.
FAQs about Septagan 450mg Tablet
Q1.
Should I use contraception during and after the treatment of the Septagan 450mg tablet?
Yes, it is advised to use contraception during and after the treatment to avoid unwanted pregnancy. Both women and men are advised to use contraception. After the treatment, it is suggested to use condoms for 30 days in women and 90 days in men.
Q2.
How can I manage side effects while taking the Septagan 450mg tablet?
Contact the healthcare professional instantly if you experience any side effects while taking the Septagan 450mg tablet. They may prescribe some over-the-counter or prescription medications to manage the side effects or reduce the tablet dosage.
Q3.
How long should I consume the Septagan 450mg tablet?
The period of the treatment completely depends on the specific condition being treated and the individual patient. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the Septagan 450mg tablet if your doctor advises you to stop.
Q4.
Can patients with impaired kidney function use the Septagan 450mg tablet?
Septagan 450mg tablet should be used with caution in individuals with impaired kidney function. Dose adjustments may be necessary, and close monitoring of kidney function is important.
Q5.
Is it safe to drink alcohol while taking a Septagan 450mg tablet?
It is unknown whether consuming alcohol while taking a Septagan 450mg tablet is safe. Drinking alcohol while consuming the medicine is generally not recommended as alcohol may increase the risk of certain side effects, such as dizziness or drowsiness, associated with the medicine. Talk with your doctor for more information.
Q6.
What are the signs of sepsis or blood infection to watch out for during Septagan 450mg tablet treatment?
Symptoms like fever, palpitations, confusion, chills and slurred speech indicate the possibility of blood infection during treatment with Septagan 450mg Tablet.
Fact Box of Septagan 450mg Tablet
Molecule name: Valganciclovir | Therapeutic class: Antiviral agent |
Pharmacological class: Nucleoside antiviral analog | Indications: 1. Treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) in adults 2. Prevention of CMV disease in adults and children receiving kidney, heart transplant |
Dosage form: Tablets | Habit forming: No |
References
- Glenmark Pharmaceuticals Europe Limited, Electronic Medicines Compendium (EMC), [Revised on December 2019] [Accessed on 19th March 2024], https://www.medicines.org.uk/emc/files/pil.11333.pdf
- Genentech USA, Inc. US Food & Drug Administration, [Revised on June 2017] [Accessed on 19th March 2024], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021304s012,022257s007lbl.pdf
- Hoffmann-La Roche Limited, [Revised on 10th September 2021], [Accessed on 19th March 2024], https://assets.roche.com/f/173850/x/ad2abcc5b2/valcyte_pm_e.pdf
- KD Tripathi, Essentials of Medical Pharmacology, Antiviral drugs, 7th edition, 2013, 801.
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Author Details
Written By
Dr. Thamizhakaran K. S.
Pharm D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:30 AM (IST)
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