SIROMUS 1MG TABLET
SIROLIMUS
Manufacturer : ZYDUS CADILAOrigin of Medicine : IndiaIntroduction:
Siromus 1mg Tablet is an immunosuppressant medication containing the active constituent called sirolimus. It helps prevent organ rejection in people who have had a kidney transplant in combination with other medications. Following an organ transplant, our body’s immune system will try to reject the new organ. This medication controls the body’s immune response to accept the transplanted organ.
It also treats a rare lung disorder called S-LAM (sporadic lymphangioleiomyomatosis). The most common symptom of this disease is shortness of breath. Before taking this medication, you need to talk to your physician if you have liver disorders, intolerance to some sugars, a family history of skin cancer, high cholesterol, or other diseases. Siromus 1mg Tablet is not recommended for adolescents and children under 18 years of age.
Avoid drinking grapefruit juice and eating grapefruits while taking this medication. Limit exposure to the sun while taking this medication. Use sunscreen with high SPF (sun protection factor) and wear protective clothing when you go outside. Avoid live vaccines during the treatment with Siromus 1mg Tablet. Use effective birth control during the treatment and for at least twelve months after the last dose.
Uses of Siromus 1mg Tablet:
- Prevents rejection of kidney transplant
- Sporadic lymphangioleiomyomatosis (lung disease)
How Siromus 1mg Tablet works:
Siromus 1mg Tablet decreases the activity of your body’s immune system and prevents it from attacking the transplanted organ.
Interactions with other drugs:
Inform your doctor about any medications you are taking or have taken before the treatment.
More information:
- Keep Siromus 1mg Tablet out of sight and reach of children.
- Do not store above 25°C.
References:
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Targeted therapies: Tyrosine kinase inhibitors, monoclonal antibodies, and cytokines, 12th edition, 2011, 1735.
- KD Tripathi, Essentials of Medical Pharmacology, Immunosuppressant drugs, 7th edition, 2013, 882.
- Pfizer Limited, Electronic medicines compendium (emc), [ Revised on July 2021] [ Accessed on 10th Dec 2021], https://www.medicines.org.uk/emc/files/pil.1368.pdf
- Pfizer, US Food and Drug Administration, [ Revised on May 2015] [ Accessed on 10th July 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021083s059,021110s076lbl.pdf
How to use Siromus 1mg Tablet:
Always take Siromus 1mg Tablet exactly as your physician has told you. Swallow the tablet whole with water. Do not crush or chew the tablets. This medicine must be consistently taken, either with or without food. Avoid drinking grapefruit juice and eating grapefruits while taking this medication.
Safety advice:
Pregnancy:
Siromus 1mg Tablet may harm your unborn baby. You need to inform your doctor if you are pregnant or planning to get pregnant before taking this medicine.
Breastfeeding:
Do not breastfeed while taking Siromus 1mg Tablet. You need to tell your doctor if you are breastfeeding before taking this medicine.
Liver:
You need to tell your doctor if you have any liver disorders before taking Siromus 1mg Tablet as this medication should be used with caution in liver disease patients.
Others:
- Inform your physician if you have any high cholesterol levels, intolerance to some sugars, family history of skin cancer, or are about to receive any vaccines before taking this medication.
- Limit exposure to the sun while taking this medication. Use sunscreen with high SPF (sun protection factor) and wear protective clothing when you go outside.
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious:
- Severe allergic reactions (swelling of face, tongue, or mouth, difficulty in breathing)
- Low blood cell counts with kidney damage
- Infections
Common:
- Headache
- Fever, pain
- High blood pressure and cholesterol levels
- Constipation, diarrhea, stomach pain
- Nausea
- Rash
- Infrequent, absent, or heave periods
- Rapid heart rate
- High blood sugar
- Joint pain
- Acne
- Swelling of the body including feet and hands

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