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Upadoz 15mg Tablet 10's
Last updated on 26 Sep 2026 | 08:41 AM (IST)
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Introduction
Upadoz 15mg Tablet 10's is a prescription medicine used to manage various autoimmune and inflammatory conditions in adults. Upadoz 15 tablet 10's belongs to the class of Janus kinase (JAK) inhibitors and works by reducing the activity of enzymes involved in immune system signalling. By controlling abnormal immune responses, Upadoz 15mg Tablet 10's helps relieve inflammation, swelling, stiffness, and pain associated with chronic inflammatory diseases.
Upadoz 15mg Tablet 10's uses include the treatment of autoimmune conditions where the immune system attacks healthy tissues, leading to inflammation and joint damage. The oral formulation provides greater convenience compared to injectable biologic therapies and may help improve long term disease control and quality of life.
The dosage of Upadoz 15mg Tablet 10's should always be determined by a healthcare professional based on the patient’s condition, treatment response, and overall health status. Regular monitoring of blood counts, liver function, and cholesterol levels is recommended during treatment because this medicine may increase the risk of infections such as tuberculosis, herpes zoster, and pneumonia.
Patients with a history of heart disease, cancer, blood clots, or chronic infections should inform their doctor before starting therapy. Upadoz 15mg Tablet 10's is not recommended during pregnancy or breastfeeding unless specifically advised by a physician.
Common side effects of Upadoz 15mg Tablet 10's may include upper respiratory infections, headache, nausea, fever, cough, increased cholesterol levels, and fatigue. Serious infections may occur in some patients and require immediate medical attention.
Patients searching for Upadoz 15mg Tablet 10's price should note that the price is generally consistent across locations. Individuals planning to buy Upadoz 15mg Tablet 10's online can purchase it through trusted platforms such as MrMed with a valid prescription.
Uses
Upadoz 15mg Tablet 10'smg uses are
Treatment of moderate to severe Rheumatoid Arthritis in adults who did not respond well to other medicines.
Management of Psoriatic Arthritis in adults with an inadequate response to conventional therapies.
Treatment of moderate to severe Atopic Dermatitis in adults who are candidates for systemic therapy.
Treatment of active Ankylosing Spondylitis in adults who did not respond adequately to conventional therapies.
Treatment of moderately to severely active Ulcerative Colitis in adults who have had an inadequate response or intolerance to other medicines.
How Upadoz 15mg Tablet 10's Works
In autoimmune diseases, the immune system becomes overactive and attacks the body's own tissues, causing inflammation and damage. Upadoz 15mg Tablet 10's inhibits Janus kinase (JAK) enzymes, which transmit signals that activate inflammation. Blocking these signals reduces immune system overactivity, lowers inflammation, and helps control symptoms of chronic inflammatory conditions.
Interaction of Upadoz 15mg Tablet 10's with Other Drugs
Taking Upadoz 15mg Tablet 10's (upadacitinib) with any of the following medicines can change the effect of either of them and may increase the risk of serious side effects.
Ketoconazole, Itraconazole, or Clarithromycin (Oral Route) Life-threatening
Use only under strict medical supervision.
These medicines may increase upadacitinib levels in the blood and raise the risk of serious infections and side effects.
Rifampicin (Oral Route) Life-threatening
Do not use together.
Rifampicin may reduce the levels of upadacitinib and decrease its effectiveness.
Carbamazepine, Phenytoin, or Phenobarbital (Oral Route) Life-threatening
Avoid using together.
These medicines may lower drug levels and lead to reduced treatment response.
Other biologic immunosuppressants such as Adalimumab or Etanercept (Injection Route) Life-threatening
Do not use together.
Concomitant use may greatly increase the risk of serious infections.
Azathioprine or Cyclosporine (Oral/Injection Route) Life-threatening
Avoid concomitant use.
Taking these medicines together may lead to excessive immune suppression.
Corticosteroids such as Prednisolone (Oral Route) Moderate
Use with caution.
Concomitant use may further increase the risk of infections.
Live vaccines such as BCG, MMR, or Varicella (Injection Route) Life-threatening
Do not receive during treatment.
This medicine affects the immune system and may increase the risk of infection after vaccination.
Storage Conditions
Store at room temperature (15–30°C).
Keep away from moisture and direct sunlight.
Do not use expired or damaged medication.
Keep out of reach of children.
How to take Upadoz 15mg Tablet 10's
Take this medicine exactly as prescribed by your doctor.
Usually taken once daily, with or without food.
Swallow the tablet whole; do not crush or chew.
Your doctor will decide the dose based on your condition and overall health.
Safety advice
Pregnancy
Upadoz 15mg Tablet 10's may harm the unborn baby. Do not use during pregnancy. Inform your doctor if you are pregnant or planning to conceive.
Breast Feeding
Avoid use while breastfeeding, as it may pass into breast milk and harm the infant.
Lungs
This medication may sometimes cause breathing difficulties, cough, or shortness of breath. Report such symptoms immediately to your doctor.
Liver
Inform your doctor if you have liver disease before starting treatment.
Alcohol
Avoid excessive alcohol consumption, as it may worsen liver-related side effects.
Driving
Dizziness and fatigue may occur in some patients. Avoid driving or operating heavy machinery if you experience these effects
Side Effects
Upadoz 15mg Tablet 10's side effects are
Serious:
Severe infections (tuberculosis, pneumonia, shingles)
Blood clots (in legs or lungs)
Chest pain, shortness of breath
Severe stomach pain or black stools
Allergic reactions (rash, swelling of face/lips, difficulty breathing)
Liver problems (yellowing of eyes/skin, dark urine)
Common:
Nausea
Cough
Fever
Headache
Stomach pain
Tiredness
Upper respiratory tract infections
Acne
Expert Tips
Do not start treatment if you have an active infection.
Your doctor may test for tuberculosis and hepatitis before starting therapy.
Routine blood tests (liver, kidney, cholesterol, blood counts) are required during treatment.
Inform your doctor if you are scheduled for vaccinations, as live vaccines are not recommended while on Upadoz 15mg Tablet 10's.
Always take the medicine as directed; do not stop suddenly without consulting your physician.
FAQs
Q1.
What is Upadoz 15mg Tablet 10's used for?
It is used to treat autoimmune conditions like rheumatoid arthritis, psoriatic arthritis, atopic dermatitis, ankylosing spondylitis, and ulcerative colitis.
Q2.
What is the correct way to use Upadoz 15mg Tablet 10's?
Take once daily as prescribed by your doctor, with or without food. Swallow the tablet whole.
Q3.
Can I use Upadoz 15mg Tablet 10's with other arthritis medicines?
It should not be combined with other biologic disease-modifying antirheumatic drugs (DMARDs). Inform your doctor about all medicines you are taking.
Q4.
Does Upadoz 15mg Tablet 10's weaken the immune system?
Yes, since it suppresses immune activity, it may increase the risk of infections.
Q5.
Do I need regular check-ups while taking this medicine?
Yes. Regular blood tests are needed to monitor liver function, kidney function, and blood counts.
Fact Box
Molecule name | Upadoz 15mg Tablet 10's |
Therapeutic class | Immunomodulators |
Pharmacological class | Janus kinase (JAK) inhibitors |
Indications | Rheumatoid Arthritis, Psoriatic Arthritis, Atopic Dermatitis, Ankylosing Spondylitis, Ulcerative Colitis |
References
A Rubbert-Roth et al., “Trial of Upadoz 15mg Tablet 10's or Abatacept in Rheumatoid Arthritis,” The New England Journal of Medicine, [October 2020], demonstrating Upadoz 15mg Tablet 10's’s remission rates compared to abatacept in RA patients https://www.nejm.org/doi/full/10.1056/NEJMoa2008250?
R Sanmartí et al., “Upadoz 15mg Tablet 10's for Patients with Rheumatoid Arthritis,” summarizing the phase II BALANCE I & II trials (dose-ranging) and the phase III SELECT trial program for RA regulatory approval https://pmc.ncbi.nlm.nih.gov/articles/PMC10002765/?
GR Burmester et al., “Safety Profile of Upadoz 15mg Tablet 10's: Descriptive Analysis in Over 27,000 Patient-Years Across Rheumatoid Arthritis, Psoriatic Arthritis, Axial Spondyloarthritis, Atopic Dermatitis, and Inflammatory Bowel Disease,” Advances in Therapy, [2025], analysing long-term safety across multiple disease indications https://pubmed.ncbi.nlm.nih.gov/36754548/
C Zhang et al., “Safety profile and dose-dependent adverse events of Upadoz 15mg Tablet 10's: a meta-analysis,” Frontiers in Pharmacology, [2025], highlighting dose-related risks such as hepatic disorders, neutropenia, and acne https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1598972/full
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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Author Details
Written By
Dr. Vikas B S
Pharm D
Reviewed By
Dr. Abhishaanth Prabu
MBBS
Last updated : 26 Sep 2026 | 08:41 AM (IST)
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